Skip to main content Accessibility help

Inflammatory cytokines and mononuclear cells in sudden sensorineural hearing loss

  • S H Yoon (a1), M E Kim (a2), H Y Kim (a1), J S Lee (a2) and C H Jang (a1)...



This study evaluated tumour necrosis factor-α, interleukins 10 and 12, and interferon-γ levels, peripheral blood mononuclear cells, and clusters of differentiation 17c and 86 expression in unilateral sudden sensorineural hearing loss.


Twenty-four patients with unilateral sudden sensorineural hearing loss, and 24 individuals with normal hearing and no history of sudden sensorineural hearing loss (who were attending the clinic for other problems), were enrolled. Peripheral blood mononuclear cells, and clusters of differentiation 11c and 86 were isolated and analysed. Plasma and supernatant levels of tumour necrosis factor-α, interferon-γ, and interleukins 10 and 12 were measured.


There were no significant differences with respect to age and gender. Monocyte population, mean tumour necrosis factor-α level and cluster of differentiation 86 expression were significantly increased in the study group compared to the control group. However, interferon-γ and interleukin 12 levels were significantly decreased. The difference in mean interleukin 10 level was not significant.


Increases in tumour necrosis factor-α level and monocyte population might play critical roles in sudden sensorineural hearing loss. This warrants detailed investigation and further studies on the role of dendritic cells in sudden sensorineural hearing loss.


Corresponding author

Author for correspondence: Dr Jun-Sik Lee, Department of Life Science, BK 21-plus Research Team for Bioactive Control Technology, Biology, College of Natural Science, Chosun University, Gwangju, South Korea E-mail: Fax: +822308850
Dr Chul Ho Jang, Department of Otolaryngology, Chonnam National University Hospital, Hakdong 8, Dongku, Gwangju, South Korea E-mail: Fax: +82 6222 06776


Hide All

Dr C H Jang takes responsibility for the integrity of the content of the paper

SH Yoon and ME Kim, both two authors contributed equally to this work.



Hide All
1Wilson, H, Alderson, DJ. Sudden sensorineural hearing loss: when is it idiopathic? J Laryngol Otol 2010;124:690–3
2Yamasoba, T, Kikuchi, S, Higo, R, O'Uchi, T, Tokumaru, A. Sudden sensorineural hearing loss associated with slow blood flow of the vertebrobasilar system. Ann Otol Rhinol Laryngol 1993;102:873–7
3Masuda, M, Kanzaki, S, Minami, S, Kikuchi, J, Kanzaki, J, Sato, H et al. Correlations of inflammatory biomarkers with the onset and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol 2012;33:1142–50
4Merchant, SN, Durand, ML, Adams, JC. Sudden deafness: is it viral? ORL J Otorhinolaryngol Relat Spec 2008;70:5260; discussion 2
5Seo, YJ, Jeong, JH, Choi, JY, Moon, IS. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: novel markers for diagnosis and prognosis in patients with idiopathic sudden sensorineural hearing loss. Dis Markers 2014;2014:702807
6Garcia-Berrocal, JR, Trinidad, A, Ramirez-Camacho, R, Lobo, D, Verdaguer, M, Ibanez, A. Immunologic work-up study for inner ear disorders: looking for a rational strategy. Acta Otolaryngol 2005;125:814–18
7Merchant, SN, Adams, JC, Nadol, JB Jr. Pathology and pathophysiology of idiopathic sudden sensorineural hearing loss. Otol Neurotol 2005;26:151–60
8Xenellis, J, Nikolopoulos, TP, Stavroulaki, P, Marangoudakis, P, Androulakis, M, Tsangaroulakis, M et al. Simultaneous and sequential bilateral sudden sensorineural hearing loss: are they different from unilateral sudden sensorineural hearing loss? ORL J Otorhinolaryngol Relat Spec 2007;69:306–10
9Demirhan, E, Eskut, NP, Zorlu, Y, Cukurova, I, Tuna, G, Kirkali, FG. Blood levels of TNF-alpha, IL-10, and IL-12 in idiopathic sudden sensorineural hearing loss. Laryngoscope 2013;123:1778–81
10Haubner, F, Martin, L, Steffens, T, Strutz, J, Kleinjung, T. The role of soluble adhesion molecules and cytokines in sudden sensorineural hearing loss. Otolaryngol Head Neck Surg 2011;144:575–80
11Keles, E, Sapmaz, E, Godekmerdan, A. The role of allergy in the etiopathogenesis of idiopathic sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol 2013;270:1795–801
12Singh, AK, Dutta, M, Chattopadhyay, R, Chakravarty, B, Chaudhury, K. Intrafollicular interleukin-8, interleukin-12, and adrenomedullin are the promising prognostic markers of oocyte and embryo quality in women with endometriosis. J Assist Reprod Genet 2016;33:1363–72
13Hiramatsu, M, Teranishi, M, Uchida, Y, Nishio, N, Suzuki, H, Kato, K et al. Polymorphisms in genes involved in inflammatory pathways in patients with sudden sensorineural hearing loss. J Neurogenet 2012;26:387–96
14Shi, C, Pamer, EG. Monocyte recruitment during infection and inflammation. Nat Rev Immunol 2011;11:762–74
15Iwamoto, S, Iwai, S, Tsujiyama, K, Kurahashi, C, Takeshita, K, Naoe, M et al. TNF-alpha drives human CD14+ monocytes to differentiate into CD70+ dendritic cells evoking Th1 and Th17 responses. J Immunol 2007;179:1449–57
16Mijovic, T, Zeitouni, A, Colmegna, I. Autoimmune sensorineural hearing loss: the otology-rheumatology interface. Rheumatology (Oxford) 2013;52:780–9
17Suslu, N, Yilmaz, T, Gursel, B. Utility of anti-HSP 70, TNF-alpha, ESR, antinuclear antibody, and antiphospholipid antibodies in the diagnosis and treatment of sudden sensorineural hearing loss. Laryngoscope 2009;119:341–6
18Trinchieri, G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003;3:133–46
19Joss, A, Akdis, M, Faith, A, Blaser, K, Akdis, CA. IL-10 directly acts on T cells by specifically altering the CD28 co-stimulation pathway. Eur J Immunol 2000;30:1683–90
20Svrakic, M, Pathak, S, Goldofsky, E, Hoffman, R, Chandrasekhar, SS, Sperling, N et al. Diagnostic and prognostic utility of measuring tumor necrosis factor in the peripheral circulation of patients with immune-mediated sensorineural hearing loss. Arch Otolaryngol Head Neck Surg 2012;138:1052–8
21Muzzi, E, Zennaro, B, Visentin, R, Soldano, F, Sacilotto, C. Hyperbaric oxygen therapy as salvage treatment for sudden sensorineural hearing loss: review of rationale and preliminary report. J Laryngol Otol 2010;124:e2
22Narozny, W, Sicko, Z, Przewozny, T, Stankiewicz, C, Kot, J, Kuczkowski, J. Usefulness of high doses of glucocorticoids and hyperbaric oxygen therapy in sudden sensorineural hearing loss treatment. Otol Neurotol 2004;25:916–23
23Ihler, F, Sharaf, K, Bertlich, M, Strieth, S, Reichel, CA, Berghaus, A et al. Etanercept prevents decrease of cochlear blood flow dose-dependently caused by tumor necrosis factor alpha. Ann Otol Rhinol Laryngol 2013;122:468–73


Related content

Powered by UNSILO

Inflammatory cytokines and mononuclear cells in sudden sensorineural hearing loss

  • S H Yoon (a1), M E Kim (a2), H Y Kim (a1), J S Lee (a2) and C H Jang (a1)...


Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.