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Immediate effects of intravenous tobramycin and gentamicin on human cochlear function

Published online by Cambridge University Press:  29 June 2007

Richard T. Ramsden ,
Peter Wilson  and
William P. R. Gibson
Richard T. Ramsden
Affiliation:
London
Peter Wilson
Affiliation:
London Adderss for reprints: Peter Wilson, Department of Clinical Microbiplogy, The London Hospital, London E.I.
William P. R. Gibson
Affiliation:
London
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Summary

Immediate electrocochleographic changes have been studied in a series of patients following intravenous infusion of either tobramycin or gentamicin. In patients receiving tobramycin, as soon as peak serum levels of antibiotic were reached, a dramatic decrease occurred in the magnitude of the compound VIII nerve action potential (AP), and of the cochlear microphonic (CM). The shape of the AP also changed. The N1 component of the waveform became very small, and N2 increased in size; this is the dissociated pattern of basal coil cochlear damage. The speed of onset of these electrical changes and their apparent reversibility suggests a temporary metabolic block caused by tobramycin. No such changes were observed following infusion of gentamicin.

Type
Clinical records
Information
The Journal of Laryngology & Otology , Volume 94 , Issue 5 , May 1980 , pp. 521 - 531
Copyright
Copyright © JLO (1984) Limited 1980

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References

Aran, J.-M., and Darrouzet, J. (1975) Observation on click-evoked compound VIII nerve responses before, during and over seven months after kanamycin treatment in the guinea-pig. Acta Otolaryngologica (Stockholm), 79, 24–32.CrossRefGoogle ScholarPubMed
Arcieri, G. M., Falco, F. G., Smith, H. M. et al. (1970) Clinical research experience with gentamicin: incidence of adverse reactions. Medical Journal of Australia (Suppl.), 1, 30–34.CrossRefGoogle ScholarPubMed
Ballantyne, J. (1976) Ototoxic Drugs. In Ronald, Hinchliffe and Donald, Harrison (eds.): Scientific Foundations of Otolaryngology, Section XIII 849–862, William Heinemann Medical Books Ltd., London.Google Scholar
Brummett, R. E., Meikle, M. M., and Vernon, J. A. (1971) Ototoxicity of tobramycin in guinea-pigs. Archives of Otolaryngology, 94, 59–63.CrossRefGoogle ScholarPubMed
Brummett, R. E., Himes, D., Saine, B., and Vernon, J. (1972) A comparative study of the ototoxicity of tobramycin and gentamicin. Archives of Otolaryngology, 96, 505–512.CrossRefGoogle ScholarPubMed
Brummett, R. E., Fox, K. E., Bendrick, T. W., and Himes, D. L. (1978) Ototoxicity of tobramycin, gentamicin, amikacin and sissomicin in the guinea-pig. Journal of Anti-microbial Chemotherapy, 4, 73–85.CrossRefGoogle ScholarPubMed
Crawford, L. M., and Bowen, J. M. (1971) Calcium binding as a property of kanamycin. American Journal of Veterinary Research, 32, 357–359.Google ScholarPubMed
Elberling, C. (1973) Transitions in cochlear action potentials recorded from the ear canal in man. Scandinavian Audiology, 2, 151–159.CrossRefGoogle Scholar
Kiang, N. Y'S., and Peake, W. T. (1960) Components of electrical responses recorded from the cochlea. Annals of Otology, Rhinology and Laryngology, 69, 190–193.CrossRefGoogle ScholarPubMed
Logan, T. B., Prazma, J., Thomas, W. et al. (1974) Tobramycin Ototoxicity. Archives of Otolaryngology, 99, 190–193.CrossRefGoogle ScholarPubMed
Meyers, R. M. (1970) Ototoxic effects of gentamicin. Archives of Otolaryngology, 92, 160–162.CrossRefGoogle ScholarPubMed
Moffat, D. A., and Ramsden, R. T. (1977) Profound bilateral sensorineural hearing loss during gentamicin therapy. Journal of Laryngology and Otology, 91, 511–516.CrossRefGoogle ScholarPubMed
Ramsden, R. T., Gibson, W. P. R., and Moffat, D. A. (1977) Anaesthesia of the tympanic membrance using iontophoresis. Journal of Laryngology and Otology, 91, 779–785.CrossRefGoogle Scholar
Reeves, D. (1974) Gentamicin therapy. British Journal of Hospital Medicine, 15, 837–850.Google Scholar
Schacht, J. (1974) Interaction of neomycin with phosphoinositide metabolism in guinea-pigs inner ear and brain tissue. Annals of Otology, Rhinology and Laryngology, 83, 613–618.CrossRefGoogle Scholar
Stephens, S. D. G. (1968) A case of gentamicin accentuated hearing loss. Journal of Laryngology and Otology, 82, 803–808.CrossRefGoogle ScholarPubMed
Supaˇek, I. (1972) Toxic hearing loss due to neomycin. A study of 26 cases. Abstract of the 11th International Congress of Audiology, Audiology, 11, 29.Google Scholar
Teas, D. C., Eldredge, D. H., and Davies, H. (1962) Cochlear responses to acoustic transients: an interpretation of whole nerve action potentials. Journal of the Acoustical Society of America, 34, No. 9, Part 2: 1438–1459.CrossRefGoogle Scholar
Wersäll, J., and Flock, A. (1964) Suppression and restoration of the microphonic output from the lateral line organ after local application of streptomycin. Life Sciences, 3, 115–1155.CrossRefGoogle Scholar
Wilson, P., and Ramsden, R. T. (1977) Immediate effects of tobramycin on human cochlea and correlation with serum tobramycin levels. British Medical Journal, 1, 259–261.CrossRefGoogle ScholarPubMed
Ylikoski, J. (1974) Guinea-pig hair cell pathology from ototoxic antibiotics. Acta Otolaryngologica, Supplement (Stockholm), 326.Google ScholarPubMed
Ylikoski, J., Wersäll, J., and Björkroth, B. (1974) Degeneration of neural elements in the cochlea of the guinea-pig after damage to the organ of Corti by ototoxic antibiotics. Acta Otolaryngologica, Supplement (Stockholm), 326.Google Scholar