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Haemostasis and analgesia with autologous platelet-rich plasma in tonsillectomy

  • M N Chettri (a1), S K Jayagandhi (a2), Y Konyak (a3), P Sobita (a4), M M Singh (a5) and A M Singh (a6)...



A single-centre, single-blinded prospective experimental study was conducted to determine the effectiveness of autologous platelet-rich plasma applied to the tonsillar bed post-operatively in reducing post-operative pain and haemorrhage.


Platelet-rich plasma, prepared prior to surgery, was applied with calcium gluconate to one randomly chosen tonsillar fossa. Pain and haemorrhage were analysed, using a visual analogue scale and a pre-defined grading scale respectively, four times on the day of surgery at 2-hourly intervals, and thrice on the following day.


The pain score and haemorrhage grade on the test side were lower than on the control side. These findings were statistically significant.


This pilot study, conducted in India, revealed valid positive results for a promising new technology. The manual preparation of platelet-rich plasma could be automated in the future to allow a larger sample size.


Corresponding author

Author for correspondence: Dr Mohonish N Chettri, Department of ENT, Sikkim Manipal Institute of Medical Sciences, Level 4 of Central Referral Hospital, Sikkim Manipal Institute of Medical Sciences, Sikkim Manipal University, Gangtok 737102, Sikkim, India E-mail:


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Dr M N Chettri takes responsibility for the integrity of the content of the paper

Presented at the 66th National Conference of the Association of Otorhinolaryngologists of India, 11 January 2014, Mysore, India.



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