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Gentamicin administration via peritoneal dialysis fluid: the risk of ototoxicity

  • B. S. Gendeh (a1), H. Said (a1), A. G. Gibb (a1), N. S. Aziz (a1) and Z. M. Zahir (a1)...

Abstract

In a prospective study on 47 patients, 16 mg of gentamicin per two litres dialysate was administered intraperitoneally at every cycle of intermittent peritoneal dialysis, carried out over the course of several days. Serum gentamicin sampling, pure tone audiometry and caloric tests were performed before and during the treatment. The gentamicin levels reached at the end of the thirtieth cycle were observed to be low. In view of this, the risk of acute ototoxicity was considered to be minimal. This was confirmed by the absence of clinical audiometric or vestibulometric evidence of toxicity.

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Corresponding author

H. Said, F.R.C.S.Ed., F.R.C.S. Glas., Associate Professor and Head of ENT Department, Faculty of Medicine, National University of Malaysia (U.K.M.), Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur.

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Paper presented at Fourth ASEAN, Otorhinolaryngological and Head and Neck Congress Organised by the Academy of Medicine, Singapore, April, 1989.

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References

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Gary, N. E. (1972) Peritoneal clearance and removal of gentamicin. Journal of Infectious Disease, 124 Supplement: 9697.
Gilman, G., Goodman, L. S., Rall, T. W., Murad, F. (1985) The Pharmacological Basis of Therapeutics, (seventh edition). Macmillan Publishing Co., New York, p. 11611162.
Hewitt, W. L. (1973) Reflections of the clinical pharmacology of gentamicin. Acta Pathologica et Microbiologica Scandinavica, Supplement. 241: 151156.
Mohan, W. A., Ecer, J. I., Fenton, S. S., Coltron, D. C. (1973) Studies on gentamicin clearance during peritoneal and hemodialysis. Clinical Research, 21: 10181019.
Selvador, P., Christina, C. (1981) Pharmacokinetics of gentamicin in patients undergoing continuous ambulatory peritoneal dialysis. Journal of Antimicrobial Chemotherapy, 19 (4): 605607.
Smithivas, T., Hyams, P. J., Matalon, P., Simberkoff, M. S., Rahal, J. J. (1971) The use of gentamicin in peritoneal dialysis. Journal of Infectious Diseases, Supplement: 7783.

Keywords

Gentamicin administration via peritoneal dialysis fluid: the risk of ototoxicity

  • B. S. Gendeh (a1), H. Said (a1), A. G. Gibb (a1), N. S. Aziz (a1) and Z. M. Zahir (a1)...

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