Skip to main content Accessibility help

Familial paraganglioma

  • S. M. Wharton (a1) and A. Davis (a1)


Non-secreting paragangliomas are rare tumours usually present in the head and neck. We describe an unusual case of familial paraganglioma with cranial nerve palsies. After exhaustive investigation, a vagal paraganglioma was found and excised. The positive family history of paraganglioma was of significance, although this was only present in one of five generations. The diagnosis and management of non-secreting paragangliomas is discussed.


Corresponding author

Address for correspondence: Dr S. M. Wharton, Department of Otorhinolaryngology, Head and Neck Surgery, Queen Alexandra Hospital, Cosham, Portsmouth, Hants.


Hide All
Anderson, R. J., Lynch, H. T. (1993) Familial risk for neuroendocrine tumours. Current Opinion in Oncology 5: 7584.
Coia, L. R., Fazekas, J. T., Farb, S. N. (1981) Familial chemodectoma. International Journal of Radiation and Biological Physics 7: 949952.
Deshmukh, N., Horbowyj, R. (1994) Paraganglioma of the vagus nerve masquerading as a carotid'body tumour. Military Medicine 159: 166168.
Geysens, P., D'Haenens, P., van Steenberge, R., Wilms, G., Baert, A. L. (1989) Familial occurrence of paragangliomas. Journal Beige De Radiologie 72: 9599.
Granger, J. K., Houn, H.-Y. (1990) Bilateral familial carotid body paragangliomas. Report of a case with DNA flow cytometric and cytogenetic analyses. Archives of Pathology and Laboratory Medicine 114: 12721275.
Irving, R. M., Moffat, D. A., Maher, E. R. (1995) Genetics of familial and non-familial skull base tumours. Clinical Otolaryngology 20: 511.
Powell, S., Peters, N., Harmer, C. (1992) Chemodectoma of the head and neck: Results of treatment in 84 patients. International Journal of Radiation and Biological Physics 22: 919924.
Ruijs, J. H., van Waes, G., Deltaas, G., Hoekstra, H., Nulder, P. H., Veldman, R. E. (1978) Screening of a family for chemodectoma. Radiologica Clinica 42: 114123.
van der Mey, A. G. L., Maaswinkel-Mooy, P. D., Cornelisse, C. J., Schmidt, P. H., van der Kamp, J. J. P. (1989) Genomic imprinting in hereditary glomus tumours: Evidence for new genetic theory. Lancet ii: 12911294.
Westbury, G. (1960) The management of carotid body tumours with a report of seven cases. British Journal of Surgery 47: 605611.



Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed