Hostname: page-component-8448b6f56d-gtxcr Total loading time: 0 Render date: 2024-04-20T02:25:17.868Z Has data issue: false hasContentIssue false
  • English
  • Français

Examination of micro-superficial lesions of up to 5 mm in size in the pharyngolaryngeal region

Published online by Cambridge University Press:  02 August 2022

T Ueda Open the ORCID record for T Ueda [Opens in a new window] ,
K Yumii ,
Y Urabe ,
N Chikuie ,
M Takumida ,
T Taruya ,
T Kono ,
T Hamamoto ,
M Hattori  and
S Oka
...Show all authors
T Ueda*
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
K Yumii
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
Y Urabe
Affiliation:
Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Japan
N Chikuie
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
M Takumida
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
T Taruya
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
T Kono
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
T Hamamoto
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
M Hattori
Affiliation:
Center for Medical Education Institute of Biomedical & Health Sciences, Hiroshima University, Japan
S Oka
Affiliation:
Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Japan
S Tanaka
Affiliation:
Department of Endoscopy, Hiroshima University Hospital, Japan
T Ishino
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
S Takeno
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
*
Author for correspondence: Dr T Ueda, Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, Hiroshima 734-8551, Japan E-mail: uedatsu@hiroshima-u.ac.jp
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

For low-grade intraepithelial neoplasia cases, pharyngolaryngeal lesions equal to or less than 5 mm in size do not generally progress to invasive carcinoma. However, micro-superficial lesions equal to or less than 5 mm that showed rapid growth have been recently encountered. This study aimed to identify the characteristics of preferential progression of lesions equal to or less than 5 mm in size.

Method

Gross findings, endoscopic findings and pathological results of 55 lesions measuring equal to or less than 5 mm in diameter were retrospectively reviewed to identify factors that distinguish squamous cell carcinoma or high-grade intraepithelial neoplasia from low-grade intraepithelial neoplasia or non-atypia lesions.

Results

The overall sensitivity, specificity, accuracy, and positive and negative predictive value of background colouration and intrapapillary capillary loop pattern in differentiation of squamous cell carcinoma or high-grade intraepithelial neoplasia from low-grade intraepithelial neoplasia or non-atypia lesions were all 100 per cent.

Conclusion

Diagnosis based on background colouration and the intrapapillary capillary loop pattern on narrow-band imaging facilitates the pathological examination of lesions measuring equal to or less than 5 mm.

Keywords

Pharyngeal NeoplasmsEarly Detection Of CancerHead And Neck NeoplasmsNarrow Band Imaging
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 137 , Issue 7 , July 2023 , pp. 749 - 756
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Dr T Ueda takes responsibility for the integrity of the content of the paper

References

Muto, M, Nakane, M, Katada, C, Sano, Y, Ohtsu, A, Esumi, H et al. Squamous cell carcinoma in situ at oropharyngeal and hypopharyngeal mucosal sites. Cancer 2004;101:1375–8110.1002/cncr.20482CrossRefGoogle ScholarPubMed
Shimizu, Y, Yoshida, T, Kato, M, Hirota, J, Ono, S, Nakagawa, M et al. Low-grade dysplasia component in early invasive squamous cell carcinoma of the oesophagus. J Gastroenterol Hepatol 2010;25:314–810.1111/j.1440-1746.2009.06032.xCrossRefGoogle Scholar
Takemura, K, Doyama, H, Nakanishi, H, Takeda, Y, Kito, Y, Ito, R et al. Can flat type brownish microlesions in the orohypopharynx be followed up without biopsy or endoscopic resection? Dig Endosc 2014;26:178–8210.1111/den.12125CrossRefGoogle ScholarPubMed
Japan Esophageal Society. Japanese Classification of Esophageal Cancer, 11th edition: part I. Esophagus 2017;14:1–3610.1007/s10388-016-0551-7CrossRefGoogle Scholar
Japan Society for Head and Neck Cancer. General Rules for Clinical Studies on Head and Neck Cancer, 6th edn. Tokyo: Kanehara, 2018Google Scholar
Japan Head and Neck Cancer Society. Cancer Committee Edition Head and neck superficial cancer handling guidelines, 2018. In: http://www.jshnc.umin.ne.jp/pdf/toriatsukaishishin.pdf [16 February 2023]Google Scholar
Tateya, I, Morita, S, Muto, M, Miyamoto, S, Hayashi, T, Funakoshi, M et al. Magnifying endoscope with NBI to predict the depth of invasion in laryngo-pharyngeal cancer. Laryngoscope 2015;125:1124–910.1002/lary.25035CrossRefGoogle ScholarPubMed
Yagishita, A, Fujii, S, Yano, T, Kaneko, K. Endoscopic findings using narrow-band imaging to distinguish between basal cell hyperplasia and carcinoma of the pharynx. Cancer Science 2014;105:857–6110.1111/cas.12440CrossRefGoogle ScholarPubMed
Muto, M, Minashi, K, Yano, T, Saito, Y, Oda, I, Nonaka, S et al. Early detection of superficial squamous cell carcinoma in the head and neck region and esophagus by narrow band imaging: a multicenter randomized controlled trial. J Clin Oncol 2010;28:1566–7210.1200/JCO.2009.25.4680CrossRefGoogle ScholarPubMed
Popek, B, Bojanowska-Poźniak, K, Tomasik, B, Fendler, W, Jeruzal-Świątecka, J, Pietruszewska, W. Clinical experience of narrow band imaging (NBI) usage in diagnosis of laryngeal lesions. Otolaryngol Pol 2019;73:18–2310.5604/01.3001.0013.3401CrossRefGoogle ScholarPubMed
Muto, M, Satake, H, Yano, T, Minashi, K, Hayashi, R, Fujii, S et al. Long-term outcome of transoral organ-preserving pharyngeal endoscopic resection for superficial pharyngeal cancer. Gastrointest Endosc 2011;74:477–8410.1016/j.gie.2011.04.027CrossRefGoogle ScholarPubMed
Tateya, I, Muto, M, Morita, S, Miyamoto, S, Hayashi, T, Funakoshi, M et al. Endoscopic laryngo-pharyngeal surgery for superficial laryngo-pharyngeal cancer. Surg Endosc 2016;30:323–910.1007/s00464-015-4213-yCrossRefGoogle ScholarPubMed
Nakamura, H, Yano, T, Fujii, S, Kadota, T, Tomioka, T, Shinozaki, T et al. Natural history of superficial head and neck squamous cell carcinoma under scheduled follow-up endoscopic observation with narrow band imaging: retrospective cohort study. BMC Cancer 2016;16:74310.1186/s12885-016-2787-yCrossRefGoogle ScholarPubMed
Shimizu, Y, Kato, M, Yamamoto, J, Ono, Y, Katsurada, T, Ono, S et al. Histologic results of EMR for esophageal lesions diagnosed as high-grade intraepithelial squamous neoplasia by endoscopic biopsy. Gastrointest Endosc 2006;63:16–2110.1016/j.gie.2005.09.027CrossRefGoogle ScholarPubMed
Kuwano, H, ed. Early Esophageal Cancer: Medical Consensus and Cutting Edge Knowledge of the Disease [in Japanese]. Tokyo: Chugai-Igakusya, 2012Google Scholar
Watanabe, A, Tsujie, H, Taniguchi, M, Hosokawa, M, Fujita, M, Sasaki, S. Laryngoscopic detection of pharyngeal carcinoma in situ with narrowband imaging. Laryngoscope 2006;116:650–410.1097/01.mlg.0000204304.38797.34CrossRefGoogle ScholarPubMed
Cosway, B, Drinnan, M, Paleri, V. Narrow band imaging for the diagnosis of head and neck squamous cell carcinoma: a systematic review. Head Neck 2016;38(suppl 1):2358–6710.1002/hed.24300CrossRefGoogle ScholarPubMed
Eguchi, K, Matsui, T, Mukai, M, Sugimoto, T. Prediction of the depth of invasion in superficial pharyngeal cancer: microvessel morphological evaluation with narrowband imaging Head Neck. 2019;41:3970–510.1002/hed.25935CrossRefGoogle ScholarPubMed
Kanzaki, H, Ishihara, R, Ishiguro, S, Nagai, K, Matsui, F, Yamashina, T et al. Histological features responsible for brownish epithelium in squamous neoplasia of the esophagus by narrow band imaging. J Gastroenterol Hepatol 2013;28:274–810.1111/jgh.12059CrossRefGoogle ScholarPubMed
Ishihara, R, Kanzaki, H, Iishi, H, Nagai, K, Matsui, F, Yamashina, T et al. Pink-color sign in esophageal squamous neoplasia, and speculation regarding the underlying mechanism. World J Gastroenterol 2013;19:4300–810.3748/wjg.v19.i27.4300CrossRefGoogle ScholarPubMed
Takahashi, M, Shimizu, Y, Ono, M, Suzuki, M, Omori, S, Yoshida, T et al. Endoscopic diagnosis of early neoplasia of the esophagus with narrow band imaging: correlations among background coloration and iodine staining findings. J Gastroenterol Hepatol 2014;29:762–810.1111/jgh.12477CrossRefGoogle ScholarPubMed
Minami, H, Inoue, H, Ikeda, H, Satodate, H, Hamatani, S, Nakao, K et al. Usefulness of background coloration in detection of esophago-pharyngeal lesions using NBI magnification. Gastroenterol Res Pract 2012;2012:52978210.1155/2012/529782CrossRefGoogle ScholarPubMed
Minami, H, Isomoto, H, Inoue, H, Akazawa, Y, Yamaguchi, N, Ohnita, K et al. Significance of background coloration in endoscopic detection of early esophageal squamous cell carcinoma. Digestion 2014;89:6–1110.1159/000356200CrossRefGoogle ScholarPubMed