Skip to main content Accessibility help

The evaluation of nasal mucociliary clearance in patients with Helicobacter pylori infection

  • S Üstün Bezgin (a1), T Çakabay (a1), K Irak (a2), M Koçyiğit (a1), B Serin Keskineğe (a1) and S Giran Örtekin (a1)...



This study aimed to examine nasal mucociliary clearance time in patients with Helicobacter pylori infection.


Fifty patients who were newly diagnosed with H pylori infection using gastric biopsy in the gastroenterology out-patient clinic, and 50 age- and gender-matched healthy adults who were admitted to the otorhinolaryngology out-patient clinic, were included in this study. After an otorhinolaryngological examination (anterior rhinoscopy and nasal endoscopic examination), the nasal mucociliary clearance time of each subject was calculated using the saccharine test.


The mean mucociliary clearance time was 06:29 ± 3:31 minutes (range, 00:55–15:19 minutes) in the control group and 10:12 ± 06:09 minutes (range, 01:28–32:00 minutes) in the study group. Comparisons of the two groups revealed a statistically significant difference (p = 0.002).


Nasal mucociliary clearance time was significantly increased in patients with H pylori infection. The results suggest that H pylori infection may have an unfavourable effect on nasal mucociliary clearance.


Corresponding author

Author for correspondence: Dr Selin Üstün Bezgin, Otorhinolaryngology Department, Kanuni Sultan Süleyman Education and Research Hospital, Atakent mahallesi, Turgut Özal caddesi No: 1, 34303, Altınşehir, Küçükçekmece, Istanbul, Turkey E-mail: Fax: +90 212 5714790


Hide All

Dr S Ü Bezgin takes responsibility for the integrity of the content of the paper



Hide All
1Suerbaum, S, Michetti, P. Helicobacter pylori infection. N Engl J Med 2002;347:1175–86
2Song, Q, Lange, T, Spahr, A, Adler, G, Bode, G. Characteristic distribution pattern of Helicobacter pylori in dental plaque and saliva detected with nested PCR. J Med Microbiol 2000;49:349–53
3Bayındır, T, Toplu, Y, Otlu, B, Yakupogulları, Y, Yıldırım, O, Kalcıoglu, MT. Prevalence of the Helicobacter pylori in the tonsils and adenoids. Braz J Otorhinolaryngol 2015;81:307–11
4Saki, N, Nikakhlagh, S, Ahmadi, K. Comparison of PCR assay and culture for detecting bacteria in middle ear fluid of children with otitis media with effusion. J Int Adv Otol 2009;5:31–4
5Ozdek, A, Cirak, MY, Samim, E, Bayiz, U, Safak, MA, Turet, S. A possible role of Helicobacter pylori in chronic rhinosinusitis: a preliminary report. Laryngoscope 2003;113:679–82
6Koç, C, Arikan, OK, Atasoy, P, Aksoy, A. Prevalence of Helicobacter pylori in patients with nasal polyps: a preliminary report. Laryngoscope 2004;114:1941–4
7Morinaka, S, Ichimiya, M, Nakamura, H. Detection of Helicobacter pylori in nasal and maxillary sinus specimens from patients with chronic sinusitis. Laryngoscope 2003;113:1557–63
8Kim, HY, Dhong, HJ, Chung, SK, Chung, KW, Chung, YJ, Jang, KT. Intranasal Helicobacter pylori colonization does not correlate with the severity of chronic rhinosinusitis. J Otolaryngol Head Neck Surg 2007;136:390–5
9Dinis, PB, Subtil, J. Helicobacter pylori and laryngopharyngeal reflux in chronic rhinosinusitis. J Otolaryngol Head Neck Surg 2006;134:6772
10Stevens, WW, Lee, RJ, Schleimer, RP, Cohen, NA. Chronic rhinosinusitis pathogenesis. J Allergy Clin Immunol 2015;136:1442–53
11Andersen, I, Camner, P, Jensen, PL, Philipson, K, Proctor, DF. A comparison of nasal and tracheobronchial clearance. Arch Environ Health 1974;29:290–3
12Rutland, J, Cole, PJ. Nasal mucociliary clearance and ciliary beat frequency in cystic fibrosis compared with sinusitis and bronchiectasis. Thorax 1981;36:654–8
13Gudis, DA, Cohen, NA. Cilia dysfunction. Otolaryngol Clin North Am 2010;43:461–72
14Gudis, D, Zhao, KQ, Cohen, NA. Acquired cilia dysfunction in chronic rhinosinusitis. Am J Rhinol Allergy 2012;26:16
15Taylor, DN, Blaser, MJ. The epidemiology of Helicobacter pylori infection. Epidemiol Rev 1991;13:4259
16Deborah, S, Prathibha, KM. Measurement of nasal mucociliary clearance. Clin Res Pulmonol 2014;2:1019
17Pandya, VK, Tiwari, RS. Nasal mucociliary clearance in health and disease. Indian J Otolaryngol Head Neck Surg 2006;58:332–4
18El-Sarag, HB, Sonnenberg, A. Comorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans. Gastroenterology 1007;113:755–60
19Ulualp, SO, Toohill, RJ, Hoffmann, R, Shaker, R. Possible relationship of gastroesophagopharyngeal acid reflux with pathogenesis of chronic sinusitis. Am J Rhinol 1999;13:197202
20Delehaye, E, Dore, MP, Bozzo, C, Mameli, L, Delitala, G, Meloni, F. Correlation between nasal mucociliary clearance time and gastroesophageal reflux disease: our experience on 50 patients. Auris Nasus Larynx 2009;36:157–61


The evaluation of nasal mucociliary clearance in patients with Helicobacter pylori infection

  • S Üstün Bezgin (a1), T Çakabay (a1), K Irak (a2), M Koçyiğit (a1), B Serin Keskineğe (a1) and S Giran Örtekin (a1)...


Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed