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Evaluation of 18fluoro-2-deoxyglucose positron emission tomography in iodine scan negative, differentiated thyroid cancer recurrence

Published online by Cambridge University Press:  16 July 2009

E J Chisholm  and
N S Tolley
E J Chisholm*
Affiliation:
Department of ENT, St Mary's Hospital, Imperial College Hospitals NHS Trust, London, UK
N S Tolley
Affiliation:
Department of ENT, St Mary's Hospital, Imperial College Hospitals NHS Trust, London, UK
*
Address for correspondence: Mr E Chisholm, 44 Eastbury Grove, London W4 2JY, UK. E-mail: edwardchisholm@doctors.org.uk
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Abstract

Background:

Follow up of patients with differentiated thyroid cancer is based upon anatomical imaging, thyroglobulin assay and functional imaging in the form of iodine uptake scanning. A significant cohort of such patients have rising thyroglobulin levels but negative iodine scans. In this group, 18fluoro-2-deoxyglucose positron emission tomography scans have been commonly employed. The aim of this study was to assess the usefulness of such investigation.

Methods:

The sensitivity of 18fluoro-2-deoxyglucose positron emission tomography for detecting recurrence of differentiated thyroid cancer was calculated from a retrospective review of scan results from patients with iodine scan negative recurrence.

Results:

Eighteen patients with rising thyroglobulin levels underwent 18fluoro-2-deoxyglucose positron emission tomography scanning. Fourteen patients had negative (and four equivocal) whole body iodine scintigraphy scans. Of these 14, six patients had a positive 18fluoro-2-deoxyglucose positron emission tomography scan, giving a sensitivity of 42.9 per cent.

Conclusions:

When assessed in the clinical setting and restricted to patients with negative iodine scans, the sensitivity of 18fluoro-2-deoxyglucose positron emission tomography was found to be lower than in previous case series.

Keywords

Thyroid NeoplasmsPositron Emission Tomography
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 123 , Issue 10 , October 2009 , pp. 1145 - 1149
Copyright
Copyright © JLO (1984) Limited 2009

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