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Epistaxis, von Willebrand's type bleeding diathesis and Wilms' tumour: a case report

  • P. V. H. Lim (a1), J. D. T. Mason (a1), D. Walker (a2) and K. P. Gibbin (a1)

Abstract

We report a case of persistent epistaxis in a seven-month-old child with Wilms' tumour who had an associated von Willebrand's type bleeding diathesis. Correction of the bleeding diathesis to control the epistaxis required treatment of the tumour with chemotherapy.

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Corresponding author

Mr J. D. T. Mason, F.R.C.S., Department of Otorhinolaryngology, University Hospital, Clifton Boulevard, Nottingham NG7 2UH.

References

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Bracey, A. W., Wu, A. H. B., Aceves, J., Chow, T., Carlile, S., Hoots, W. K. (1987) Platelet dysfunction associated with Wilms' tumour and hyaluronic acid. American Journal of Haematoloy 24: 247257.
Coppes, M. J., Zandvoort, S. W. H., Sparling, C. R., Poon, A. O., Weiteman, S., Blanchette, V. S. (1992) Acquired von Willebrand's disease in Wilms' tumour patients. Journal of Clinical Oncology 10: 422427.
Han, P., Lou, J., Wong, H. B. (1987) Wilms' tumour in acquired von Willebrand's disease. Australian Paediatric Journal 23: 253255.
Morse, B. S., Nussbaum, M. (1967) The detection of hyaluronic acid in the serum and urine of a patient with nephroblastoma. American Journal of Medicine 42: 9961002.
Noronha, P. A., Hruby, M. A., Maurer, H. S. (1979) Acquired von Willebrand's disease in a patient with Wilms' tumour. Journal of Pediatrics 95: 997999.
Powars, D. R., Allerton, S. E., Beierke, J., Butler, B. B. (1972) Wilms' tumour, clinical correlation with circulating mucin in three cases. Cancer 29: 15971605.
Scott, J. P., Montgomery, R. R., Tubergen, D. G., Hays, T. (1981) Acquired von Willebrand's disease in association with Wilms' tumour: regression following treatment. Blood 58: 665669.
Wu, A. H. B., Parker, O. S., Fard, L. S. (1984) Hyperviscosity caused by hyaluronic acid in serum in a case of Wilms' tumour. Clinical Chemistry 30: 914916.

Keywords

Epistaxis, von Willebrand's type bleeding diathesis and Wilms' tumour: a case report

  • P. V. H. Lim (a1), J. D. T. Mason (a1), D. Walker (a2) and K. P. Gibbin (a1)

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