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Efficacy of low-dose intratympanic dexamethasone as a salvage treatment for idiopathic sudden sensorineural hearing loss: the Modbury Hospital experience

Published online by Cambridge University Press:  24 January 2014

S Oue ,
J Jervis-Bardy ,
L Stepan ,
S Chong  and
C-K L Shaw
S Oue*
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Modbury Hospital, Adelaide, South Australia, Australia
J Jervis-Bardy
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Modbury Hospital, Adelaide, South Australia, Australia
L Stepan
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Modbury Hospital, Adelaide, South Australia, Australia
S Chong
Affiliation:
Division of Surgery, University of Adelaide, South Australia, Australia
C-K L Shaw
Affiliation:
Division of Surgery, University of Adelaide, South Australia, Australia
*
Address for correspondence: Ms Sakiko Oue, Department of Otolaryngology Head and Neck Surgery, Modbury Hospital, 41–69 Smart Rd, Modbury, SA 5092, Australia Fax: +61 (08) 8161 2685 E-mail: sakiko.oue@gmail.com
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Abstract

Objective:

To evaluate the efficacy of low-dose intratympanic dexamethasone therapy in patients with idiopathic sudden sensorineural hearing loss whose hearing in the affected ear had failed to improve following a course of oral steroid therapy.

Methods:

A prospective pilot study was undertaken of eight patients with idiopathic sudden sensorineural hearing loss whose hearing had failed to improve after a course of prednisolone. These patients subsequently received 8 mg intratympanic dexamethasone therapy, delivered via a ventilation tube on a weekly basis for 1 month. Clinical outcome was assessed weekly with pure tone audiography.

Results:

At the end of the 1-month treatment period, no significant hearing improvement was observed on pure tone audiography in any of the patients (i.e. improvements were all less than 10 dB).

Conclusion:

The response to 8 mg of intratympanic dexamethasone used as a salvage therapy for idiopathic sudden sensorineural hearing loss was inadequate. A higher dosage of intratympanic dexamethasone might be required to achieve better outcomes.

Keywords

Hearing Loss, SensorineuralDexamethasoneTreatment
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 128 , Issue S2 , July 2014 , pp. S27 - S30
Copyright
Copyright © JLO (1984) Limited 2014 

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Footnotes

Presented at the Australian Society of Otolaryngology Head and Neck Surgery Annual Scientific Meeting, 19 March 2013, Perth, Western Australia, Australia

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