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Effects of agmatine sulphate on facial nerve injuries

  • O Surmelioglu (a1), L Sencar (a2), S Ozdemir (a1), O Tarkan (a1), M Dagkiran (a1), N Surmelioglu (a3), U Tuncer (a1) and S Polat (a2)...

Abstract

Objective:

To evaluate the effect of agmatine sulphate on facial nerve regeneration after facial nerve injury using electron and light microscopy.

Methods:

The study was performed on 30 male Wistar albino rats split into: a control group, a sham-treated group, a study control group, an anastomosis group, and an anastomosis plus agmatine sulphate treatment group. The mandibular branch of the facial nerve was dissected, and a piece was removed for histological and electron microscopic examination.

Results:

Regeneration was better in the anastomosis group than in the study control group. However, the best regeneration findings were seen in the agmatine sulphate treatment group. There was a significant difference between the agmatine group and the others in terms of median axon numbers (p < 0.004) and diameters (p < 0.004).

Conclusion:

Agmatine sulphate treatment with anastomosis in traumatic facial paralysis may enhance nerve regeneration.

Copyright

Corresponding author

Address for correspondence: Dr Ozgur Surmelioglu, Department of Otorhinolaryngology, Faculty of Medicine, Cukurova University, Adana, Turkey Fax: +90 322 338 6527 E-mail: surmeli2004@yahoo.com

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The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
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