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Effect of early postnatal air-conduction auditory deprivation on the development and function of the rat spiral ganglion

Published online by Cambridge University Press:  13 June 2011

F Wang ,
X Gao ,
J Chen ,
S-L Liu ,
F-Y Wang ,
R-Y Hei ,
Y Chen  and
J-H Qiu
F Wang
Affiliation:
Department of Otolaryngology, General Hospital of Air Force, Beijing, People's Republic of China Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
X Gao
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China Department of Otorhinolaryngology, Head and Neck Surgery, General Hospital of Second Artillery, Beijing, People's Republic of China
J Chen
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
S-L Liu
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
F-Y Wang
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
R-Y Hei
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
Y Chen*
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
J-H Qiu
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi, People's Republic of China
*
Address for correspondence: Dr Yang Chen, Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P R China Fax: +86 29 83224749 E-mail: chendoc@fmmu.edu.cn
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Abstract

Objective:

To evaluate the effect of early postnatal air-conduction auditory deprivation on the development and function of the rat spiral ganglion.

Study design:

Randomised animal study.

Methods:

Sixty neonatal Sprague–Dawley rats were randomly divided into two groups: controls (n = 30) given regular chow and water ad libitum; and study animals (n = 30) fed within a soundproof chamber. Auditory brainstem response testing was conducted in both groups on postnatal day 42.

Results:

Auditory deprivation between postnatal days 12 and 42 resulted in an increased hearing threshold and reduced auditory brainstem response amplitudes, together with degeneration of type I spiral ganglion neurons and the presence of apoptotic cells.

Conclusion:

Non-invasive auditory deprivation during a critical developmental period resulted in numerous changes in rat cochlear function and morphology.

Keywords

CochleaRatsSpiral GanglionSensory DeprivationNeuron-Specific EnolaseHearing
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 9 , September 2011 , pp. 917 - 923
Copyright
Copyright © JLO (1984) Limited 2011

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References

1Arlinger, S, Gatehouse, S, Bentler, RA, Byrne, D, Cox, RM, Dirks, DD et al. Report of the Eriksholm Workshop on auditory deprivation and acclimatization. Ear Hear 1996 Jun;17(3 Suppl):87S–98SCrossRefGoogle ScholarPubMed
2Schnupp, JW, Carr, CE. On hearing with more than one ear: lessons from evolution. Nat Neurosci 2009;12:692–7CrossRefGoogle ScholarPubMed
3Silman, S, Gelfand, S, Silverman, C. Late onset auditory deprivation: effect of monaural versus binaural hearing aids. J Acoust Soc Am 1984;76:1357–62CrossRefGoogle ScholarPubMed
4Harding, GW, Bohne, BA, Ahmad, M. DPOAE level shifts and ABR threshold shifts compared to detailed analysis of histopathological damage from noise. Hear Res 2002;174:158–71CrossRefGoogle ScholarPubMed
5Deol, MS, Kocher, W. A new gene for deafness in the mouse. Heredity 1958;12:463–6CrossRefGoogle Scholar
6Leake, PA, Stakhovskaya, O, Hradek, GT, Hetherington, AM. Factors influencing neurotrophic effects of electrical stimulation in the deafened developing auditory system. Hear Res 2008;242:86–99CrossRefGoogle ScholarPubMed
7Kim, JW, Dang, CV. Multifaceted role of glycolytic enzymes. Trends Biochem Sci 2005;30:142–50CrossRefGoogle Scholar
8Rochefort, C, Gheusi, G, Vincent, JD, Lledo, PM. Enriched odor exposure increases the number of newborn neurons in the adult olfactory bulb and improves odor memory. J Neurosci 2002;22:2679–89CrossRefGoogle ScholarPubMed
9Rittenhouse, CD, Shouval, HZ, Paradiso, MA, Bear, MF. Monocular deprivation induces homosynaptic long-term depression in visual cortex. Nature 1999;397:347–50CrossRefGoogle ScholarPubMed
10Di Cristo, G, Berardi, N, Cancedda, L, Pizzorusso, T, Putignano, E, Ratto, GM et al. Requirement of ERK activation for visual cortical plasticity. Science 2001;292:2337–40CrossRefGoogle ScholarPubMed
11Sanes, DH, Markowitz, S, Bernstein, J, Wardlow, J. The influence of inhibitory afferents on the development of postsynaptic dendritic arbors. J Comp Neurol 1992;321:637–44CrossRefGoogle ScholarPubMed
12Kakazu, Y, Akaike, N, Komiyama, S, Nabekura, J. Regulation of intracellular chloride by cotransporters in developing lateral superior olive neurons. J Neurosci 1999;19:2843–51CrossRefGoogle ScholarPubMed
13Geal-Dor, M, Freeman, S, Li, G, Sohmer, H. Development of hearing in neonatal rats: air and bone conducted ABR thresholds. Hear Res 1993;69:236–42CrossRefGoogle ScholarPubMed
14Nakahara, H, Zhang, LI, Merzenich, MM. Specialization of primary auditory cortex processing by sound exposure in the “critical period”. Proc Natl Acad Sci U S A 2004;101:7170–4CrossRefGoogle ScholarPubMed
15Webster, DB, Webster, M. Neonatal sound deprivation affects brain stem auditory nuclei. Arch Otolaryngol 1977;103:392–3CrossRefGoogle ScholarPubMed
16Webster, DB, Webster, M. Effects of neonatal conductive hearing loss on brain stem auditory nuclei. Ann Otol Rhinol Laryngol 1979;l88:684–8CrossRefGoogle Scholar
17Dmitrieva, LP, Gottlieb, G. Influence of auditory experience on the development of brain stem auditory evoked potentials in mallard duck embryos and hatchlings. Behav Neural Biol 1994;61:19–28CrossRefGoogle ScholarPubMed
18Games, KD, Winer, JA. Layer V in rat auditory cortex: projections to the inferior colliculus and contralateral cortex. Hear Res 1988;34:1–25CrossRefGoogle Scholar
19Blatchley, BJ, Williams, JE, Coleman, JR. Age-dependent effects of acoustic deprivation on spherical cells of the rat anteroventral cochlear nucleus. Exp Neurol 1983;80:81–93CrossRefGoogle ScholarPubMed
20Walger, M, Laska, M, Schneider, I, Diekmann, H, von Wedel, H. Maturation of auditory evoked potentials in young guinea pigs with binaural conductive hearing loss. Eur Arch Otorhinolaryngol 1993;250:362–5CrossRefGoogle ScholarPubMed
21Dammeijer, PF, Schlundt Bodien, QC, Chenault, MN, Manni, JJ, Anteunis, LJ. Effects of early auditory deprivation and stimulation on auditory brainstem responses in the rat. Acta Otolaryngol 2002;122:703–8CrossRefGoogle ScholarPubMed