Skip to main content Accessibility help
×
×
Home

Effect of early postnatal air-conduction auditory deprivation on the development and function of the rat spiral ganglion

  • F Wang (a1) (a2), X Gao (a2) (a3), J Chen (a2), S-L Liu (a2), F-Y Wang (a2), R-Y Hei (a2), Y Chen (a2) and J-H Qiu (a2)...

Abstract

Objective:

To evaluate the effect of early postnatal air-conduction auditory deprivation on the development and function of the rat spiral ganglion.

Study design:

Randomised animal study.

Methods:

Sixty neonatal Sprague–Dawley rats were randomly divided into two groups: controls (n = 30) given regular chow and water ad libitum; and study animals (n = 30) fed within a soundproof chamber. Auditory brainstem response testing was conducted in both groups on postnatal day 42.

Results:

Auditory deprivation between postnatal days 12 and 42 resulted in an increased hearing threshold and reduced auditory brainstem response amplitudes, together with degeneration of type I spiral ganglion neurons and the presence of apoptotic cells.

Conclusion:

Non-invasive auditory deprivation during a critical developmental period resulted in numerous changes in rat cochlear function and morphology.

Copyright

Corresponding author

Address for correspondence: Dr Yang Chen, Department of Otorhinolaryngology, Head and Neck Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P R China Fax: +86 29 83224749 E-mail: chendoc@fmmu.edu.cn

References

Hide All
1Arlinger, S, Gatehouse, S, Bentler, RA, Byrne, D, Cox, RM, Dirks, DD et al. Report of the Eriksholm Workshop on auditory deprivation and acclimatization. Ear Hear 1996 Jun;17(3 Suppl):87S–98S
2Schnupp, JW, Carr, CE. On hearing with more than one ear: lessons from evolution. Nat Neurosci 2009;12:692–7
3Silman, S, Gelfand, S, Silverman, C. Late onset auditory deprivation: effect of monaural versus binaural hearing aids. J Acoust Soc Am 1984;76:1357–62
4Harding, GW, Bohne, BA, Ahmad, M. DPOAE level shifts and ABR threshold shifts compared to detailed analysis of histopathological damage from noise. Hear Res 2002;174:158–71
5Deol, MS, Kocher, W. A new gene for deafness in the mouse. Heredity 1958;12:463–6
6Leake, PA, Stakhovskaya, O, Hradek, GT, Hetherington, AM. Factors influencing neurotrophic effects of electrical stimulation in the deafened developing auditory system. Hear Res 2008;242:8699
7Kim, JW, Dang, CV. Multifaceted role of glycolytic enzymes. Trends Biochem Sci 2005;30:142–50
8Rochefort, C, Gheusi, G, Vincent, JD, Lledo, PM. Enriched odor exposure increases the number of newborn neurons in the adult olfactory bulb and improves odor memory. J Neurosci 2002;22:2679–89
9Rittenhouse, CD, Shouval, HZ, Paradiso, MA, Bear, MF. Monocular deprivation induces homosynaptic long-term depression in visual cortex. Nature 1999;397:347–50
10Di Cristo, G, Berardi, N, Cancedda, L, Pizzorusso, T, Putignano, E, Ratto, GM et al. Requirement of ERK activation for visual cortical plasticity. Science 2001;292:2337–40
11Sanes, DH, Markowitz, S, Bernstein, J, Wardlow, J. The influence of inhibitory afferents on the development of postsynaptic dendritic arbors. J Comp Neurol 1992;321:637–44
12Kakazu, Y, Akaike, N, Komiyama, S, Nabekura, J. Regulation of intracellular chloride by cotransporters in developing lateral superior olive neurons. J Neurosci 1999;19:2843–51
13Geal-Dor, M, Freeman, S, Li, G, Sohmer, H. Development of hearing in neonatal rats: air and bone conducted ABR thresholds. Hear Res 1993;69:236–42
14Nakahara, H, Zhang, LI, Merzenich, MM. Specialization of primary auditory cortex processing by sound exposure in the “critical period”. Proc Natl Acad Sci U S A 2004;101:7170–4
15Webster, DB, Webster, M. Neonatal sound deprivation affects brain stem auditory nuclei. Arch Otolaryngol 1977;103:392–3
16Webster, DB, Webster, M. Effects of neonatal conductive hearing loss on brain stem auditory nuclei. Ann Otol Rhinol Laryngol 1979;l88:684–8
17Dmitrieva, LP, Gottlieb, G. Influence of auditory experience on the development of brain stem auditory evoked potentials in mallard duck embryos and hatchlings. Behav Neural Biol 1994;61:1928
18Games, KD, Winer, JA. Layer V in rat auditory cortex: projections to the inferior colliculus and contralateral cortex. Hear Res 1988;34:125
19Blatchley, BJ, Williams, JE, Coleman, JR. Age-dependent effects of acoustic deprivation on spherical cells of the rat anteroventral cochlear nucleus. Exp Neurol 1983;80:8193
20Walger, M, Laska, M, Schneider, I, Diekmann, H, von Wedel, H. Maturation of auditory evoked potentials in young guinea pigs with binaural conductive hearing loss. Eur Arch Otorhinolaryngol 1993;250:362–5
21Dammeijer, PF, Schlundt Bodien, QC, Chenault, MN, Manni, JJ, Anteunis, LJ. Effects of early auditory deprivation and stimulation on auditory brainstem responses in the rat. Acta Otolaryngol 2002;122:703–8
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The Journal of Laryngology & Otology
  • ISSN: 0022-2151
  • EISSN: 1748-5460
  • URL: /core/journals/journal-of-laryngology-and-otology
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed