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DNA flow cytometry of acinic cell carcinomas of major salivary glands

Published online by Cambridge University Press:  29 June 2007

Adel K. El-Naggar ,
J. G. Batsakis ,
Mario A. Luna ,
Donia McLemore  and
R. M. Byers
Adel K. El-Naggar
Affiliation:
Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
J. G. Batsakis*
Affiliation:
Departments of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Mario A. Luna
Affiliation:
Departments of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Donia McLemore
Affiliation:
Departments of Veterinary Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
R. M. Byers
Affiliation:
Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
*
Dr J. G. Batsakis, M.D., Department of Pathology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.
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Abstract

Fifteen acinic cell carcinomas from an equal number of patients were analysed for their DNA content and proliferative (S-phase) index by flow cytometry from archival tissues. Seven of the carcinomas manifested a diploid DNA content. None of the patients with diploid acinic cell carcinomas died of their carcinomas and none developed metastases in follow-up periods extending for 10 or more years. Four of eight patients with aneuploid acinic cell carcinomas have died because of their malignancies within a 10 year period after the first surgical removal of the carcinoma. Five of the eight patients exhibited metastases. Although the number of cases does not permit strong correlations between histopathological features, abnormalities in DNA content and outcome of patients, it was noted that carcinomas with prominent necrosis, tubulo ductal differentiation and ‘dedifferentiated’ areas displayed more aggressive biological courses.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 104 , Issue 5 , May 1990 , pp. 410 - 416
Copyright
Copyright © JLO (1984) Limited 1990

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References

Abrams, A. M., Cornyn, J., Scofield, H. H., Hansen, L. S. (1965) Acinic cell adenocarcinoma of the major salivary glands. A clinicopathologic study of 77 cases. Cancer, 18: 1145–1162.Google Scholar
Baisch, H., Göhde, W., Linden, W. A. (1975) Analysis of PCP-data to determine the fraction of cells in the various phases of cells cycle. Radiation and Environmental Biophysics, 12: 31–39.CrossRefGoogle Scholar
Barlogie, B., Göhde, W., Johnston, D. A., Smallwood, L., Schumann, J., Drewinko, B., Freieich, E. J. (1978) Determination of ploidy and proliferative characteristics of human solid tumors by pulse cytophotometry. Cancer Research, 38: 3333–3339.Google ScholarPubMed
Barlogie, B., Schumann, J., Dosik, G., Johnston, D. A., Freireich, F. J. (1980) Cellular DNA content as a marker of neoplasia in man. American Journal of Medicine, 69: 195–203.CrossRefGoogle ScholarPubMed
Batsakis, J. G., Chinn, E. K., Weimert, T. A., Work, W. P., Krause, C. J. (1979) Acinic cell carcinoma: a clinicopathologic study of 35 cases. Journal of Laryngology and Otology, 93: 325–340.CrossRefGoogle ScholarPubMed
Büchner, T., Hiddemann, W., Wörmann, B., Kleinemier, B., Schumann, J., Göhde, W., Ritter, J., Müller, K. M., von Bassewitz, D. B., Roessner, A., Grundmann, E. (1985) Differential pattern of DNA-aneuploidy in human malignancies. Pathology, Research, Practice, 179: 310–317.CrossRefGoogle ScholarPubMed
Ellis, G. L., Corio, R. L. (1983) Acinic cell adenocarcinoma. A clinicopathologic analysis of 294 cases. Cancer, 52: 542–549.3.0.CO;2-A>CrossRefGoogle ScholarPubMed
Eneroth, C. M., Silfverswärd, C, Zetterberg, A. (1974) Malignancy of acinic cell tumors elucidated by microspectrophotometric DNA analysis. Acta Otolaryngologica, 77: 126–130.CrossRefGoogle Scholar
Eneroth, C. M., Zetterberg, A. (1976) A cytochemical method of grading the malignancy of salivary gland tumors preoperatively. Acta Otolaryngologica, 81: 489–195.Google Scholar
Gustaffson, H., Lindholm, C, Carlsöo, B. (1987) DNA cytophotometry of acinic cell carcinomas and its relation to prognosis. Acta Otolaryngologica, 104: 370–376.Google Scholar
Hamper, K., Mausch, H. E., Caselitz, J., Arps, H., Berger, J., Askenster, U., Auer, G., Seifert, G. (1990) Acinic cell carcinoma of the salivary glands: the prognostic relevance of DNA cytophometry in a retrospective study of long duration (1965–1987) Oral Surgery, Oral Medicine, Oral Pathology, 69: 68–75.CrossRefGoogle Scholar
Hedley, D. W., Friedlander, M. L., Taylor, I. W. (1983) Method for analysis of cellular DNA content of paraffin-embedded pathological materials using flow cytometry. Journal of Histochemistry and Cytochemistry, 31: 1333–1335.Google Scholar
McLemore, D. D., Wall, T. J., Stephens, L. C., Jardine, J. H. (1987) Processing of paraffin embedded tissue for flow cytometry. Journal of Histotechnology, 10: 109–113.CrossRefGoogle Scholar
Merkel, D. E., Dressler, L. G., McGuire, W. L. (1987) Flow cytometry, cellular DNA content and prognosis in human malignancy. Journal of Clinical Oncology, 5: 1690–1703.CrossRefGoogle ScholarPubMed
Perzin, K. H., LiVolsi, V. (1979) Acinic cell carcinomas arising in salivary glands. A clinicopathologic study. Cancer, 44: 1434–1457.3.0.CO;2-H>CrossRefGoogle ScholarPubMed
Sharkey, F. E. (1977) Systematic evaluation of the World Health Organization classification of salivary gland tumors. A clinicopathologic study of 366 cases. American Journal of Clinical Pathology, 67: 272–278.CrossRefGoogle ScholarPubMed
Spiro, R. H., Huvos, A. G., Strong, W. W. (1975) Cancer of the parotid gland, a clinicopathologic study of 288 primary cases. American Journal of Surgery, 130: 452–459.CrossRefGoogle ScholarPubMed
Spiro, R. H., Huvos, A. G., Strong, E. W. (1978) Acinic cell carcinoma of salivary origin. Cancer, 41: 924–934.Google Scholar
Stanley, R. J., Weiland, L. H., Olsen, K. D., Pearson, B. W. (1988) Dedifferentiated acinic cell (acinous) carcinomas of the parotid gland. Otolaryngology—Head and Neck Surgery, 98: 155–161.Google Scholar
Thackray, A. C, Sobin, L. H. (1972) Histological Typing of Salivary Gland Tumors, pp. 23–24, World Health Organization, Geneva, Switzerland.Google Scholar