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Diffuse lipomatosis of the thyroid with amyloid deposition

Published online by Cambridge University Press:  23 January 2013

T A Jacques  and
M P Stearns
T A Jacques*
Affiliation:
Department of ENT, Lister Hospital, Stevenage, UK
M P Stearns
Affiliation:
Department of ENT, Royal Free Hospital, London, UK
*
Address for correspondence: Dr T A Jacques, Department of ENT, Lister Hospital, Corey's Mill Lane, Stevenage SG1 4AB, UK E-mail: tjacques@doctors.org.uk
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Abstract

Background:

The authors present a case of diffuse fatty infiltration of the thyroid gland with coexistent deposition of amyloid protein.

Method:

A case history and brief literature review concerning amyloid goitre and fatty infiltration of the thyroid are presented, and the relationship between these two phenomena is discussed.

Results:

A patient with AA amyloidosis presented with a slowly enlarging goitre, which on histological examination was extensively infiltrated with adipose tissue. Amyloid protein was found on Congo red staining.

Conclusion:

To our best knowledge, this patient represents the first reported case of diffuse lipomatosis of the thyroid gland causing goitre in a patient with AA amyloidosis. The presence of amyloid protein within the thyroid was not sufficient to cause enlargement per se, and was therefore of unclear significance. Together with previous reports of the concurrent deposition of amyloid and fat, this case raises questions as to the relationship between these two phenomena.

Keywords

GoiterThyroid GlandLipomatosisAmyloidosisAdipose TissueLipomaPathology
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 127 , Issue 4 , April 2013 , pp. 426 - 428
Copyright
Copyright © JLO (1984) Limited 2013

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