Skip to main content Accessibility help
×
Home

The diagnostic value of positron emission tomography (PET) with radiolabelled fluorodeoxyglucose (18F-FDG) in head and neck cancer

  • N. J. Slevin (a1), C. D. Collins (a2), D. L. Hastings (a3), M. L. Waller (a3), R. J. Johnson (a2), R. A. Cowan (a1), A. R. Birzgalis (a4), W. T. Farrington (a4) and R. Swindell (a5)...

Abstract

Positron emission tomography (PET) scanning has recently been introduced into clinical practice but its usefulness in the management of head and neck cancer is not well defined. The aim of this prospective preliminary study was to examine the clinical value of fluorodeoxyglucose (FDG) – PET in patients with head and neck cancer treated by radiotherapy with surgery in reserve by (i) relating quantitative uptake of isotope to tumour type and histological grade and (ii) comparing the imaging findings of PET and magnetic resonance imaging (MRI) in post-radiotherapy assessment of tumour response. Twenty-one patients had pre-treatment PET and MRI scans and these were repeated four and eight months after treatment if there was no clinical relapse. Pre-treatment uptake of FDG using tumour to cerebellar ratio parameters was significantly related to the histological grade of squamous cancer (p = 0.04) but not to tumour type. Discordance of post-treatment PET/MRI findings in one case indicates a possible role for PET in the early detection of tumour recurrence. Other potential uses of PET scanning in the management of head and neck cancer are discussed.

Copyright

Corresponding author

Address for correspondence: Dr N. J. Slevin, F.R.C.R., F.R.C.R., Department of Clinical Oncology, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX.

References

Hide All
Anzai, Y., Carroll, W. R., Quint, D. J., Bradford, C. R., Minoshima, S., Wolf, G. T., Wahl, R. L. (1996) Recurrence of head and neck after surgery or irradiation: prospective comparison of 2-deoxy-2-[F-18] fluoro-D-glucose PET and MR imaging diagnoses. Radiology 200(1): 135141.
Bailet, J. W., Sercarz, J. A., Abemayor, E., Anzai, Y., Lufkin, R. B., Hoh, C. K. (1995) The use of positron emission tomography for early detection of recurrent head and neck squamous cell carcinoma in postradiotherapy patients. Laryngoscope 105(2): 135139.
Braams, J. W., Pruim, J., Freling, N. J., Nikkels, P. G., Roodenburg, J. L., Boering, G., Vaalburg, W., Vermey, A. (1995) Detection of lymph node metastases of squamouscell cancer of the head and neck with FDG-PET and MRI. Journal of Nuclear Medicine 36(2): 211216.
Braams, J. W., Pruim, J., Kole, A. C., Nikkels, P. G., Vaalburg, W., Vermey, A., Roodenburg, J. L. (1997) Detection of unknown primary head and neck tumours by positron emission tomography. International Journal of Oral Maxillofacial Surgery 26(2): 112115.
Chaiken, L., Rege, S., Hoh, M. D., Choi, Y., Jabour, B., Juillard, G., Hawkins, R., Parker, R. (1993) Positron emission tomography with flurordeoxyclucose to evaluate tumour response and control after radiation therapy. International Journalof Radiation Oncology Biology and Physics 27: 455464.
DiChiro, G., DeLaPaz, R. L., Brooks, R. A. (1982) Glucose utilization of cerebral gliomas measured by (18F) Fluorodeoxy glucose and positron emission tomography. Neurology 32: 13231329.
Greven, M. K., Williams, D. W. III, Keyes, J. W. Jr., McGuirt, W. F., Watson, N. E. Jr., Randall, M. E., Raben, M., Geisinger, K. R., Cappellari, J. O. (1994) Positron emission tomography of patients with head and neck carcinoma before and after high dose irradiation. Cancer 74: 13551359.
Haberkorn, U., Strauss, L. G., Dimitrakopoulou, A., Seiffert, E., Oberdorfer, F., Ziegler, S., Reisser, C., Doll, J., Helus, F., van Kaick, G. (1993) Fluorodeoxyglucose imaging of advanced head and neck cancer after chemotherapy. Journal of Nuclear Medicine 34: 1217.
Hastings, D. L., Moore, J. V., Waller, M. L., Acton, P. D., Dodd, N. J., Hand, J. C., Nuttall, P. M., Jeavons, A. P. (1996) High resolution PET imaging of tumour using 18FDG in Quantitative Imaging in Oncology. Proceedings of the 19th LH Gray Conference (Faulkner, K., Carey, B., Crellin, A. eds.) British Journal of Radiology London.
Laubenbacher, C., Saumweber, D., Wagner-Manslau, C., Kau, R. J., Herz, M., Avril, N., Siegler, S., Kruschke, C., Arnold, W., Schwaiger, M. (1995) Comparison of fluorine-18-fluorodoxyglucose PET, MRI and endoscopy for staging head and neck squamous-cell carcinomas. Journal of Nuclear Medicine 36(10): 17471757.
Leskinnen-Kallio, S., Ruotsalainen, U., Nagren, K., Teras, M., Joensuu, H. (1991) Uptake of carbon-11-methionine and FDG in non Hodgkins lymphoma: a PET study. Journal of Nuclear Medicine 32: 12111218.
McGuirt, W. F., Williams, D. W. III, JrKeyes, J. W., Greven, K. M., JrWatson, N. E., Geisinger, K. R., Cappellari, J. O. (1995) A comparative diagnostic study of head and neck nodal metastases using positron emission tomography. Laryngoscope 105(4 Pt 1): 373375.
Minn, H., Joensuu, H., Ahonen, A. (1988) Fluorodeoxyglucose imaging: a comparison with DNA flow cytometry in head and neck tumours. Cancer 61: 17761781.
Moore, J. V., Hastings, D. L., Waller, M. L., Zhao, S., Acton, P. D., Jeavons, A. P., Dodd, N. J. F. (1998) Feasibility of imaging photodynamic injury to tumours by high resolution positron emission tomography: pre-clinical studies. European Journal Nuclear Medicine 25: 12481254.
Mukherji, S. K., Drane, W. E., Mancuso, A. A., Parsons, J. T., Mendenhall, W. M., Stringer, S. (1996) Occult primary tumours of the head and neck: detection with 2-[F-18] fluoro-2-doxy-D-glucose SPECT. Radiology 199(3): 761766.
Price, P., Jones, T., on behalf of the EC PET Oncology Concerted Action and the EORTC PET Study Group (1995) Can positron emission tomography (PET) be used to detect subclinical response to cancer therapy? European Journal of Cancer 31A(12): 19241927.
Rege, S., Maass, A., Chaiken, L., Hoh, C. K., Choi, Y., Lufkin, R., Anzai, Y., Juillard, G., Maddahi, J., Phelps, M. E. (1994) Use of positron emission tomography with fluorodeoxyglucose in patients with extracranial head and neck cancers. Cancer 73: 30473058.
Siegel, S. (1956) Non-Parametric Statistics for the Behavioural Sciences Chapter 8. McGraw-Hill, New York, Toronto, London. pp 184193.
Townsend, D. (1987) High density avalanche chamber (HIDAC) positron camera. Journal of Nuclear Medicine 28: 15541562.
Wong, W. L., Chevretton, E. B., McGurk, M., Hussain, K., Davis, J., Beaney, R., Baddeley, H., Tierney, P., Maisey, M. (1997) A prospective study of PET-FDG imaging for the assessment of head and neck squamous cell carcinoma. Clinical Otolaryngology 22: 209214.

Keywords

The diagnostic value of positron emission tomography (PET) with radiolabelled fluorodeoxyglucose (18F-FDG) in head and neck cancer

  • N. J. Slevin (a1), C. D. Collins (a2), D. L. Hastings (a3), M. L. Waller (a3), R. J. Johnson (a2), R. A. Cowan (a1), A. R. Birzgalis (a4), W. T. Farrington (a4) and R. Swindell (a5)...

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed