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Current status and clinical association of beta-catenin with juvenile nasopharyngeal angiofibroma

  • A Mishra (a1), V Singh (a1), V Verma (a1), S Pandey (a2), R Trivedi (a3), H P Singh (a1), S Kumar (a1), R C Dwivedi (a4) and S C Mishra (a5)...



A possible role of the APC/beta-catenin pathway in the pathogenesis of sporadic juvenile nasopharyngeal angiofibroma has been suggested. This paper presents its current status and clinical association in our patients.


A prospective observational study was conducted at King George Medical University and Central Drug Research Institute, in Lucknow, India. Western blot analysis was undertaken in 16 cases to examine beta-catenin expression. The clinical details were recorded along with follow up observations, to determine associations.


Up-regulation of beta-catenin expression was seen in 69 per cent of cases. The clinical variables did not reveal significant differences between patients with extremes of expression (extreme under- vs over-expression). However, absent expression was shown exclusively in young adults aged over 18 years, while enhanced expression was associated with an altered facial profile.


Although a beta-catenin association was seen in a subset of our sporadic juvenile nasopharyngeal angiofibroma cases, its expression was not homogeneous. This is in contrast to the Western literature that suggests a universal (homogenous) enhanced expression in the majority. Hence, further research is required to better define its molecular cascade.


Corresponding author

Address for correspondence: Dr Anupam Mishra, Department of Otorhinolaryngology, King George Medical University, Lucknow, India E-mail:


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1 Barth, AI, Nathke, IS, Nelson, WJ. Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways. Curr Opin Cell Biol 1997;9:683–90
2 Behrens, J, von Kries, JP, Kühl, M, Bruhn, L, Wedlich, D, Grosschedl, R et al. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 1996;382:638–42
3 Rubinfeld, B, Albert, I, Porfiri, E, Fiol, C, Munemitsu, S, Polakis, P. Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly. Science 1996;272:1023–6
4 Munemitsu, S, Albert, I, Souza, B, Rubinfeld, B, Polakis, P. Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc Natl Acad Sci U S A 1995;92:3046–50
5 Aberle, H, Bauer, A, Stappert, J, Kispert, A, Kemler, R. Beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 1997;16:3797–804
6 Orford, K, Crockett, C, Jensen, JP, Weissman, AM, Byers, SW. Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin. J Biol Chem 1997;272:24735–8
7 Morin, PJ, Sparks, AB, Korinek, V, Barker, N, Clevers, H, Vogelstein, B et al. Activation of beta-catenin-Tcf signaling in colon cancers by mutations in beta-catenin or APC. Science 1997;275:1787–90
8 Korinek, V, Barker, N, Morin, PJ, van Wichen, D, de Weger, R, Kinzler, KW et al. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon cancer. Science 1997;275:1784–7
9 Kinzler, KW, Vogelstein, B. Lessons from hereditary colorectal cancer. Cell 1996;87:159–70
10 Sparks, AB, Morin, PJ, Vogelstein, B, Kinzler, KW. Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. Cancer Res 1998;58:1130–4
11 Gardner, EJ. Follow-up study of a family group exhibiting dominant inheritance for a syndrome including intestinal polyps, osteomas, fibromas, and epidermal cysts. Am J Hum Genet 1962;14:376–90
12 Klemmer, S, Pascoe, L, DeCosse, J. Occurrence of desmoids in patients with familial adenomatous polyposis of the colon. Am J Med Genet 1987;28:385–92
13 Krush, AJ, Traboulsi, EI, Offerhaus, GJ, Maumenee, IH, Yardley, JH, Levin, LS. Hepatoblastoma, pigmented ocular fundus lesions and jaw lesions in Gardner syndrome. Am J Med Genet 1988;29:323–32
14 Bell, B, Mazzaferri, EL. Familial adenomatous polyposis (Gardner's syndrome) and thyroid carcinoma: a case report and review of the literature. Dig Dis Sci 1993;38:185–90
15 Walsh, N, Qizilbash, A, Banerjee, R, Waugh, GA. Biliary neoplasia in Gardner's syndrome. Arch Pathol Lab Med 1987;111:76–7
16 Hamilton, SR, Liu, B, Parsons, RE, Papadopoulos, N, Jen, J, Powell, SM et al. The molecular basis of Turcot's syndrome. N Engl J Med 1995;332:839–47
17 Giardiello, FM, Hamilton, SR, Krush, AJ, Offerhaus, JA, Booker, SV, Petersen, GM. Nasopharyngeal angiofibroma in patients with familial adenomatous polyposis. Gastroenterology 1993;105:1550–2
18 Ferouz, AS, Morh, RM, Paul, P. Juvenile nasopharyngeal angiofibroma and familial adenomatous polyposis: an association? Otolaryngol Head Neck Surg 1995;113:435–9.
19 Abraham, SC, Montgomery, EA, Giardiello, FM, Wu, TT. Frequent beta-catenin mutations in juvenile nasopharyngeal angiofibromas. Am J Pathol 2001;158:1073–8
20 Klockars, T, Renkonen, S, Leivo, I, Hagström, J, Mäkitie, AA. Juvenile nasopharyngeal angiofibroma: no evidence for inheritance or association with familial adenomatous polyposis. Fam Cancer 2010;9:401–3
21 Lerner, C, Wemmert, S, Schick, B. Preliminary analysis of different microRNA expression levels in juvenile angiofibromas. Biomed Rep 2014;2:835–8
22 Mishra, A, Mishra, SC. Changing trends in the incidence of juvenile nasopharyngeal angiofibroma: seven decades of experience at King George's Medical University, Lucknow, India. J Laryngol Otol 2016;130:363–8
23 Mishra, SC, Shukla, GK, Bhatia, N, Pant, MC. A rational classification of angiofibromas of the postnasal space. J Laryngol Otol 1989;103:912–16
24 Pawlowski, JE, Ertel, JR, Allen, MP, Xu, M, Butler, C, Wilson, EM et al. Liganded androgen receptor interaction with beta-catenin: nuclear co-localization and modulation of transcriptional activity in neuronal cells. J Biol Chem 2002;277:20702–10
25 Valanzano, R, Curia, MC, Aceto, G, Veschi, S, De Lellis, L, Catalano, T et al. Genetic evidence that juvenile nasopharyngeal angiofibroma is an integral FAP tumour. Gut 2005;54:1046–7
26 Guertl, B, Beham, A, Zechner, R, Stammberger, H, Hoefler, G. Nasopharyngeal angiofibroma: an APC-gene associated tumor? Hum Pathol 2000;31:1411–13
27 Garcia-Rostan, G, Tallini, G, Herrero, A, D'Aquila, TG, Carcangiu, ML, Rimm, DL. Frequent mutation and nuclear localization of beta-catenin in anaplastic thyroid carcinoma. Cancer Res 1999;59:1811–15
28 Voeller, HJ, Truica, C, Gelmann, EP. Beta-catenin mutations in human prostate cancer. Cancer Res 1998;58:2520–3
29 Fukuchi, T, Sakamoto, M, Tsuda, H, Maruyama, K, Nozawa, S, Hirohashi, S. Beta-catenin mutation in carcinoma of the uterine endometrium. Cancer Res 1998;58:3526–8
30 Palacios, J, Gamallo, C. Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas. Cancer Res 1998;58:1344–7
31 Mirabelli-Primdahl, L, Gryfe, R, Kim, H, Millar, A, Luceri, C, Dale, D et al. Beta-catenin mutations are specific for colorectal carcinomas with microsatellite instability but occur in endometrial carcinomas irrespective of mutator pathway. Cancer Res 1999;59:3346–51
32 Koesters, R, Ridder, R, Kopp-Schneider, A, Betts, D, Adams, V, Niggli, F et al. Mutational activation of the beta-catenin proto-oncogene is a common event in the development of Wilms’ tumors. Cancer Res 1999;59:3880–2
33 Miyoshi, Y, Iwao, K, Nagasawa, Y, Aihara, T, Sasaki, Y, Imaoka, S et al. Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Res 1998;58:2424–7
34 Huang, H, Fujii, H, Sankila, A, Mahler-Araujo, BM, Matsuda, M, Cathomas, G et al. Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection. Am J Pathol 1999;155:1795–801
35 Hus, HC, Jeng, YM, Mao, TL, Chu, JS, Lai, PL, Peng, SY. Beta-catenin mutations are associated with a subset of low-grade hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis. Am J Pathol 2000;157:763–70
36 Zhang, PJ, Weber, R, Liang, H, Pasha, TL, LiVolsi, VA. Growth factors and receptors in juvenile nasopharyngeal angiofibroma and nasal polyps. Arch Pathol Lab Med 2003;127:1480–4



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