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Clinicoradiological characteristics of patients with differentiated thyroid carcinoma and renal metastasis: case series with follow up

Published online by Cambridge University Press:  30 January 2014

P Kand  and
S Basu
P Kand
Affiliation:
Radiation Medicine Centre (BARC), Tata Memorial Centre Annexe, Mumbai, India
S Basu*
Affiliation:
Radiation Medicine Centre (BARC), Tata Memorial Centre Annexe, Mumbai, India
*
Address for correspondence: Dr Sandip Basu, Radiation Medicine Centre (BARC), T M C Annexe, Jerbai Wadia Rd, Parel, Mumbai 400012, India Fax: +91 (0)22 24157098 E-mail: drsanb@yahoo.com
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Abstract

Background:

Renal metastasis is relatively unusual in patients with differentiated thyroid carcinoma.

Methods:

The clinicoradiological parameters of a series of patients with differentiated thyroid carcinoma and renal metastasis were assessed, together with follow-up data.

Results and conclusion:

The series comprised 4 male patients over the age of 45 years with extensive disease at the primary site. Retro-sternal extension of a large goitre was observed in three patients. The primary tumour was 4 cm or larger in all patients (range, 4–14 cm), and three patients had associated lymph node metastasis. None had any genito-urinary symptoms at presentation. Two patients had isolated renal metastases with no other distant metastases, while the others had extensive multi-organ involvement. The bilateral occurrence of lesions was a hallmark, being observed in all cases. Ultrasound-guided fine needle aspiration cytology and 131I scintigraphy were pivotal in confirming the diagnosis. Evidence of ‘flip-flop’ between 131I study and fluoro-deoxyglucose positron emission tomography was noted in one patient, while the other three demonstrated concordant lesions in both modalities. At a minimum follow-up period of four years after diagnosis, three patients demonstrated stable disease with radioiodine therapy, and one had expired due to a poorly differentiated lung carcinoma which developed subsequently.

Keywords

Thyroid CarcinomaNeoplasm MetastasisKidneyFluorodeoxyglucose F18Positron Emission TomographyTomographyX-Ray Computed
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 128 , Issue 2 , February 2014 , pp. 203 - 208
Copyright
Copyright © JLO (1984) Limited 2014 

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