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Clinical investigation of olfactory and auditory function in type I pseudohypoparathyroidism: participation of adenylate cyclase system

Published online by Cambridge University Press:  29 June 2007

K. Ikeda ,
T. Sakurada ,
Y. Sasaki ,
T. Takasaka  and
Y. Furukawa
K. Ikeda*
Affiliation:
From the Department of Otolaryngology and the Second Internal Medicine, 1-1 Seriyomachi, Sendai 980, Japan.
T. Sakurada
Affiliation:
From the Department of Otolaryngology and the Second Internal Medicine, 1-1 Seriyomachi, Sendai 980, Japan.
Y. Sasaki
Affiliation:
From the Department of Otolaryngology and the Second Internal Medicine, 1-1 Seriyomachi, Sendai 980, Japan.
T. Takasaka
Affiliation:
From the Department of Otolaryngology and the Second Internal Medicine, 1-1 Seriyomachi, Sendai 980, Japan.
Y. Furukawa
Affiliation:
Tohoku University School of Medicine, 1-1 Seriyomachi, Sendai 980, Japan.
*
Katsuhisa Ikeda, M.D.,Department of Otolaryngology, Medical Research East, University of Minnesota, 2630 University Avenue, S.E., Minneapolis, Minnesota 55414, U.S.A.
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Abstract

Olfactory and auditory function was examined in five patient with type I pseudohyppoarathyroidism; in two patient the activity of stimulatory guanine nucleotide-binding protein was examined and found to have low values. The olfactory tests were performed by T & T olfactometer and intravenous injection of thiamine propyl disulphide. The four patients receiving olfactory test showed a disturbance in recoginzation of the odorants. All five patients had normal hearing at frequencies with the normal range. An adenylate cyclase system is thought to play an important role in olfactory transduction, whereas cochlear function may be unaffected by this system in the normal state.

Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 102 , Issue 12 , December 1988 , pp. 1111 - 1114
Copyright
Copyright © JLO (1984) Limited 1988

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