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Carcinoma ex pleomorphic adenoma of the soft palate

  • Toshio Yoshihara (a1), Masayo Tanaka (a1), Mitsuko Itoh (a2) and Tetsuo Ishii (a1)


A case of carcinoma ex pleomorphic adenoma arising in the soft palate is reported. The tumour presented had enlarged gradually over 10 years and finally occupied the oral cavity. The patient was admitted to our hospital due to disturbance of her speech and swallowing, and a sudden haemorrhage from the tumour. The initial pathological diagnosis by open biopsy was benign pleomorphic adenoma. After total resection, histological examination revealed that the tumour was composed partly of benign pleomorphic adenoma and partly of an adenocarcinomatous component. The carcinoma cells with prominent nucleoli were spheroid or polygonal in shape, and frequently formed ductal structures with areas of necrosis. Mitoses were also found. These findings showed that this tumour was a secondary carcinoma which had developed in a preexisting pleomorphic adenoma.


Corresponding author

Address for correspondence: Dr Toshio Yoshihara, Department of Otolaryngology, Tokyo Women's Medical College, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162, Japan


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Batsakis, J. G. (1974) Tumors of the head and neck. Clinical and pathological consideration, Williams & Wilkins Co., Baltimore, pp 151.
Bears, O. H., Woolner, L. B., Kirklin, J. W., Devine, K. D. (1957) Carcinomatous transformation of mixed tumors of the parotid gland. Archives of Surgery 75: 605614.
Boles, R., Raines, J., Lebovits, M., Fu, K. (1980) Malignant tumors of salivary glands: a university experience. Laryngoscope 90: 729736.
Chen, K. T. K. (1978) Metastasizing pleomorphic adenoma of the salivary gland. Cancer 42: 24072411.
Da-Quan, Ma., Guang-yan, Yu. (1987) Tumours of the minor salvary glands. Acta Ololaryngologica (Stockholm) 103: 325331.
Eneroth, C. M., Blanck, C., Jakobsson, P. A. (1968) Carcinoma in pleomorphic adenoma of the parotid gland. Acta Orolaryngologica (Stockholm) 66: 477492.
Eneroth, C. M., Zetterberg, A. (1974) Malignancy in pleomorphic adenoma: a clinical and microspectrophotometric study. Acta Otolaryngologica (Stockholm) 77: 462–432.
Evans, R. W., Cruickshank, A. H. (1970) Carcinoma ex mixed tumour epithelial tumors of the salivary glands. In Major Problems in Pathology. (Bennington, J. L., ed.), W. B. Saunders, Co., Philadelphia, pp 226241.
Foote, F. W., Frazell, E. L. (1953) Tumors of the major salivary glands. Cancer 6: 10651133.
Gerughty, R. M., Scofleld, H. H., Brown, F. M., Hennigar, G. R. (1969) Malignant mixed tumors of salivary gland origin. Cancer 24: 471486.
Gnepp, D. R., Wenig, B. M. (1991) Malignant mixed tumor. In Surgical Pathology of the Salivary Glands, (Ellis, G. L., Auclair, P. L., Gnepp, D. R., eds.), W. B. Saunders Co., Philadelphia, pp 350368.
Hickman, R. E., Cawson, R. A., Duffy, S. W. (1984) The prognosis of specific types of salivary gland tumors. Cancer 54: 16201624.
Livolsi, V. A., Perzin, K. H. (1977) Malignant mixed tumors arising in salivary glands: 1: Carcinomas arising in benign mixed tumors: a clinicopathologic study. Cancer 39: 22092239.
Moberger, J. G., Eneroth, C. M. (1968) Malignant mixed tumors of the major salivary glands. Special reference to the histologic structure in metastases. Cancer 21: 11981211.
Nagao, K., Matsuzaki, O., Saiga, H., Sugano, I., Shigematsu, H., Kaneko, T., Katoh, T., Kitamura, T. (1981) Histopathologic studies on carcinoma in pleomorphic adenoma of the parotid gland. Cancer 48: 113121.
Rauch, S., Seifert, G., Gorlin, R. J. (1970) Diseases of salivary glands: tumors. In Thomas' Oral Pathology, (Gerlin, R. J., Goldman, H. M., eds.), C. V. Mosby Co., St Louis, pp 10031070.
Regezi, J. A., Lloid, R. V., Zarbo, R. J., McClatchey, K. D. (1985) Minor salivary gland tumors. A histologic and immunohistochemical study. Cancer 55: 108115.
Spiro, R. H., Huvos, A. G., Strong, E. W. (1977) Malignant mixed tumors of salivary origin. A clinicopathologic study of 146 cases. Cancer 39: 388396.
Spitz, M. R., Batsakis, J. G. (1984) Major salivary gland carcinoma. Archives of Otolaryngology 110: 4549.
Thackray, A. C., Lucas, R. B. (1974) Tumors of the major salivary glands. In Atlas of Tumor of Pathology, Second series, Fascicle, 10, Armed Forces Institute of Pathology, Washington, D.C., pp 107117.
Waldron, C. A., El-Mofty, S. K., Gnepp, D. R. (1988) Tumors of the intraoral minor salivary glands: a demographic and histologic study 426 cases. Oral Surgery, Oral Medicine, Oral Pathology 66: 323333.



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