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Benign schwannoma in paranasal sinuses: a clinico-pathological study of five cases, emphasising diagnostic difficulties

  • H Y Sheikh (a1), R P Chakravarthy (a2), N J Slevin (a1), A J Sykes (a1) and S S Banerjee (a2)...

Abstract

Objectives:

To highlight the difficulty in making a correct diagnosis of benign schwannoma in the paranasal region, to raise awareness of this rare condition, and to suggest the most appropriate treatment.

Method:

Retrieval of cases retrospectively from archives of the histopathology department of a major UK cancer centre with central review of all cases.

Results:

Five cases were identified since 1990 and clinical and pathological features are summarised. Median follow up of patients was 8.1 years. Radiological appearances of local bone invasion and histological features of tumour unencapsulation and hypercellularity could give the mistaken impression of malignant disease and lead to unnecessary over-treatment.

Conclusion:

Central pathological review and clinical awareness is required. Although local recurrence can occur, the prognosis is excellent. The treatment of choice is local excision. Radiotherapy can be considered, but in most cases it would incur unnecessary morbidity.

Copyright

Corresponding author

Address for correspondence: Dr Hamid Sheikh, Department of Clinical Oncology, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester M20 4BX, UK. E-mail: hamid.sheikh@christie-tr.nwest.nhs.uk

References

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1 Hasegawa, SL, Mentzel, T, Fletcher, CD. Schwannomas of the sinonasal tract and nasopharynx. Mod Pathol 1997;10:777–84
2 Buob, D, Wacrenier, A, Chevalier, D, Aubert, S, Quinchon, J, Gosselin, B et al. Schwannoma of the sinonasal tract: a clinicopathologic and immunohistochemical study of 5 cases. Arch Pathol Lab Med 2003;127:1196–9
3 Donnelly, MJ, Al-Sader, MH, Blayney, AW. Benign nasal schwannoma. J Laryngol Otol 1992;106:1011–15
4 Robitaille, Y, Seemayer, TA, El Deiry, A. Peripheral nerve tumors involving paranasal sinuses: a case report and review of the literature. Cancer 1975;35:1254–8
5 Leakos, M, Brown, DH. Schwannomas of the nasal cavity. J Otolaryngol 1993;22:106–7
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Keywords

Benign schwannoma in paranasal sinuses: a clinico-pathological study of five cases, emphasising diagnostic difficulties

  • H Y Sheikh (a1), R P Chakravarthy (a2), N J Slevin (a1), A J Sykes (a1) and S S Banerjee (a2)...

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