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Acute labyrinthitis associated with systemic Candida albicans infection in ageing mice

Published online by Cambridge University Press:  29 June 2007

Robert B. Ashman ,
John M. Papadimitriou  and
Alma Fulurija
Robert B. Ashman*
Affiliation:
Department of Pathology, University of Western Australia, Nedlands, WA. 6009. Australia
John M. Papadimitriou
Affiliation:
Department of Pathology, University of Western Australia, Nedlands, WA. 6009. Australia
Alma Fulurija
Affiliation:
Department of Pathology, University of Western Australia, Nedlands, WA. 6009. Australia
*
Address for correspondence: Dr R. B. Ashman, Department of Pathology, University of Western Australia, Nedlands, W.A. 6009. Australia. Fax: 61 9 346 2891
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Abstract

The yeast Candida albicans is an important opportunistic pathogen that has been associated with disease of the inner ear. This study describes the histopathology of acute labyrinthitis caused by systemic infection with C. albicans in ageing inbred mice. Within four days after infection, yeast and hyphal forms of C. albicans were found in the membranous labyrinth. The utricle and the adjacent parts of the ampullary regions of the semicircular canals were most severely affected, but damage was also seen in the scala media, the Scala tympani, the saccule, and the scala vestibuli. In the utricle, the lining epithelium of the membranous labyrinth was disrupted, and the lining cells of the vestibular membrane showed foci in which the membrane was disrupted. The data suggest that age may represent a risk factor for fungal labyrinthitis.

Keywords

Candida a1bican LabyrinthitisAgeing
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 110 , Issue 1 , January 1996 , pp. 13 - 18
Copyright
Copyright © JLO (1984) Limited 1996

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