Skip to main content Accessibility help

Acrokeratosis paraneoplastica: Bazex syndrome

  • Michael J. Wareing (a1), Samantha A. Vaughan-Jones (a2) and David H. McGibbon (a2)


Bazex syndrome, or acrokeratosis paraneoplastica, is a cutaneous paraneoplastic syndrome characterized by psoriasiform lesions associated with, usually, a squamous cell carcinoma of the upper aerodigestive tract. We present a case of Bazex syndrome associated with metastatic cervical squamous cell carcinoma with an unknown primary. The features of the condition are discussed in the light of current knowledge.


Corresponding author

Address for correspondence: Mr M. J. Wareing, 14 Woodlands Park Road, Greenwich, SE10 9XD.


Hide All
Bazex, A., Griffiths, A. (1980) Acrokeratosis paraneoplastica - a new cutaneous marker of malignancy. British Journal of Dermatology 102: 301306.
Bolognia, J. A., Brewer, Y. P., Cooper, D. L. (1991) Bazex syndrome (acrokeratosis paraneoplastica). Medicine 70(4): 269280.
Douglas, W. S., Bilsland, D. J., Howatson, R. (1991) Acrokeratosis paraneoplastica of Basex - a case in the UK. Clinical and Experimental Dermatology 16: 297299.
Halpern, S. M., O'Donnell, L. J. D., Makunura, C. N. (1995) Acrokeratosis paraneoplastica of Bazex in association with a metastatic neuroendocrine tumour. Journal of the Royal Society of Medicine 88: 353354.
Handfield-Jones, S. E., Matthews, C. N. A., Ellis, J. P., Das, K. B., McGibbon, D. H. (1992) Acrokeratosis paraneoplastica of Basex. Journal of the Royal Society of Medicine 85: 548550.
Hara, M., Hunayama, M., Aiba, S., Suetake, T., Watanabe, M., Tanaka, M., Tagami, H. (1995) Acrokeratosis paraneoplastica (Bazex syndrome) associated with primary cutaneous squamous cell carcinoma of the lower leg, vitiligo and alopecia areata. British Journal of Dermatology 133: 121124.
Lever, W. F., Schaumburg-Lever, G. (1990) In Histopathology of the Skin. 7th Edition, J. B. Lippincott and Co., Philadelphia, pp 103112, 156174, 284285, 494506.
Lucker, G. P. H., Steijlen, P. M. (1995) Acrokeratosis paraneoplastica (Bazex syndrome) occurring with acquired ichthyosis in Hodgkin's disease. British Journal of Dermatology 133: 322325.
Martin, R. W., Cornitius, T. G., Naylor, M. F., Neldner, K. H. (1989) Bazex's syndrome in a woman with pulmonary adenocarcinoma. Archives of Dermatology 125: 847848.
Pecora, A. L., Landsman, L., Imgrund, S. P., Lambert, C. (1983) Acrokeratosis paraneoplastica (Bazex syndrome). Report of a case and review of the literature. Archives of Dermatology 119: 820826.
Saito, K., Tamura, A., Narimatsu, H., Tadakuma, T., Nagashima, N. (1986) Cloned auto-la-reactive T cells elicit lichen planus-like lesion in the skin of syngeneic mice. Journal of Immunology 137: 24852495.
Wishart, J. M. (1986) Bazex paraneoplastic acrokeratosis: a case report and response to Tigason. British Journal of Dermatology 115: 595599.


Acrokeratosis paraneoplastica: Bazex syndrome

  • Michael J. Wareing (a1), Samantha A. Vaughan-Jones (a2) and David H. McGibbon (a2)


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.