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Treatment experience with and clinicopathological analysis of vocal fold leukoplakia per appearance classification guidance: a cohort of 1442 patients

Published online by Cambridge University Press:  15 September 2023

Chang Jiang Li
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai, China
Min Chen
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai, China
Jian Chen
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai, China
Hai Tao Wu*
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai, China
Pei Jie He*
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai, China
Lei Cheng*
Affiliation:
Department of Otorhinolaryngology, Head and Neck Surgery, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai, China
*
Corresponding authors: Hai Tao Wu; Email: eentwuhaitao@163.com Pei Jie He; Email: hepj2002@sina.com Lei Cheng; Email: tomorrowhot@163.com
Corresponding authors: Hai Tao Wu; Email: eentwuhaitao@163.com Pei Jie He; Email: hepj2002@sina.com Lei Cheng; Email: tomorrowhot@163.com
Corresponding authors: Hai Tao Wu; Email: eentwuhaitao@163.com Pei Jie He; Email: hepj2002@sina.com Lei Cheng; Email: tomorrowhot@163.com

Abstract

Objective

To analyse the comparative clinical outcomes and clinicopathological significance of vocal fold leukoplakia lesions treated by appearance classification and traditional methods.

Method

A total of 1442 vocal fold leukoplakia patients were enrolled. Group A patients were treated according to appearance classification and Group B patients were treated according to traditional methods.

Results

In Group A, 24.4, 14.9 and 60.6 per cent of patients had grade I, II and III dysplasia, respectively. Grade I dysplasia (63.4 per cent) was more than twice as frequent in Group B patients than in Group A patients, while grade II dysplasia (20.4 per cent) and grade III dysplasia (16.2 per cent) were significantly less frequent in Group B patients than in Group A patients (p = 0.000). There was a significant correlation between vocal fold leukoplakia appearance and the degree of dysplasia (p = 0.000). The recurrence and malignant transformation rates (17.6 and 31 per cent, respectively) in Group B were significantly greater than those in Group A (10.8 and 25.9 per cent, respectively) (p = 0.000).

Conclusion

Vocal fold leukoplakia appearance classification is useful for guiding treatment decision-making and could help to improve therapeutic accuracy.

Type
Main Article
Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Hai Tao Wu takes responsibility for the integrity of the content of the paper

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