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Tranexamic acid has no advantage in head and neck surgical procedures: a randomised, double-blind, controlled clinical trial

Published online by Cambridge University Press:  18 November 2019

A Thakur
Affiliation:
Department of Pharmacology, Indira Gandhi Medical College, Shimla, India
S Gupta
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Indira Gandhi Medical College, Shimla, India
J S Thakur
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Indira Gandhi Medical College, Shimla, India
R S Minhas
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Indira Gandhi Medical College, Shimla, India
R K Azad
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Indira Gandhi Medical College, Shimla, India
M S Vasanthalakshmi
Affiliation:
Department of Biostatistics, All India Institute of Speech and Hearing, Mysore, India
D R Sharma
Affiliation:
Department of Pharmacology, Indira Gandhi Medical College, Shimla, India
N K Mohindroo
Affiliation:
Department of Otolaryngology – Head and Neck Surgery, Indira Gandhi Medical College, Shimla, India
Corresponding
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Abstract

Objective

To assess the effect of tranexamic acid in head and neck surgical procedures.

Methods

A prospective, double-blind and randomised, parallel group, placebo-controlled clinical trial was conducted. Ninety-two patients undergoing various head and neck surgical procedures were randomised. Subjects received seven infusions of coded drugs (tranexamic acid or normal saline) starting at the time of skin closure. Haematological, biochemical, blood loss and other parameters were observed by the staff, who were blinded to patients’ group allocation (case or control).

Results

Patients were analysed on the basis of type of surgery. Fifty patients who had undergone surgical procedures, including total thyroidectomy, total parotidectomy, and various neck dissections with or without primary tumour excision, were included in the first group. The second group comprised 41 patients who had undergone hemithyroidectomy, lobectomy or superficial parotidectomy. There was no statistical difference in blood parameters between both groups. There was a reduction in post-operative drain volume, but this was not significant.

Conclusion

Although this prospective, randomised, placebo-controlled clinical trial found a reduction in post-operative drain volume in tranexamic acid groups, the difference was not statistically significant between the various head and neck surgical procedure groups.

Type
Main Articles
Copyright
Copyright © JLO (1984) Limited, 2019

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Footnotes

Dr J S Thakur takes responsibility for the integrity of the content of the paper

References

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Tranexamic acid has no advantage in head and neck surgical procedures: a randomised, double-blind, controlled clinical trial
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