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Tests with a new compound (Praziquantel) against Diphyllobothrium latum

  • G. Bylund (a1), B. Bång (a1) and K. Wikgren (a1)

Abstract

Praziquantel (Droncit) is a new anthelminthic agent with a strikingly wide therapeutic index. The efficiency of the drug against Diphyllobothrium latum was tested in vivo and in vitro. With a drug dose of 50 mg/kg, artificially infected hamsters were completely cured. The threshold value of the active dose was between 2·5 and 10·0 mg/kg. Clinical trials with Praziquantel against human diphyllobothriasis show great promise, all of ten patients treated with 25·0 mg/kg of the drug being cured. Praziquantel had little effect on larval or adult diphyllobothriids in vitro.

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Rommel, M., Grelck, H. and Hörnchner, F. (1976) Zur Wirksamkeit von Praziquantel gegen Bandwürmer in experimentell infizierten Hunden und Katzen. Berliner und Münchener Tierärztliche Wochenschrift, 89, 255257.
Thomas, H., Gönnert, R., Pohlke, R. and Seubert, J. (1975a) Experimental and clinical studies with a new compound against tapeworms. Paper read at the 2nd European Multi-Colloquy of Parasitology, Trogir, Yugoslavia, 1975, pp. 14.
Thomas, H., Gönnert, R., Pohlke, R. and Seubert, J. (1975b) Experience with a new compound against larval cestodes. Paper read at the 2nd European Multi-Colloquy of Parasitology, Trogir, Yugoslavia, 1975, pp. 14.

Tests with a new compound (Praziquantel) against Diphyllobothrium latum

  • G. Bylund (a1), B. Bång (a1) and K. Wikgren (a1)

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