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Studies on humoral immunity against Taenia taeniaeformis infection in rats

Published online by Cambridge University Press:  05 June 2009

B. H. Kwa  and
F. Y. Liew
B. H. Kwa
Affiliation:
Department of Zoology and Genetics and Cellular Biology, University of Malaya, Kuala Lumpur, Malaysia
F. Y. Liew
Affiliation:
Department of Zoology and Genetics and Cellular Biology, University of Malaya, Kuala Lumpur, Malaysia
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Abstract

Rats were infected with doses of 100, 1000, 5000 and 10 000 eggs of Taenia taeniaeformis. Haemagglutinating antibody to cysticercus antigen was detected at the 4th week of infection. The appearance and levels of antibody titre did not vary greatly with the infective dose. An IgM peak appeared at the 6th week, with IgG appearing slightly later and continuing to rise. Transfer of serum from the 1st week onwards from infections with 1000 eggs however could confer significant protection. Dilutions of hyperimmune serum (1 ml volumes) of up to 1/32 conferred significant protection on normal recipients. Hyperimmune serum transferred up to 4 days before challenge could confer 80% protection whereas serum transferred 4 days after challenge was totally non-protective. The significance of this finding is discussed in the light of current knowledge of metacestode immunity.

Type
Research Papers
Information
Journal of Helminthology , Volume 52 , Issue 2 , June 1978 , pp. 99 - 107
Copyright
Copyright © Cambridge University Press 1978

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References

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