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In vitro effect of ivermectin on Pseudoterranova decipiens survival

Published online by Cambridge University Press:  05 June 2009

K. M. Manley  and
J. A. Embil
K. M. Manley
Affiliation:
Department of Microbiology, Sir Charles Tupper Medical Building, Dalhousie University, Halifax, Nova Scotia, Canada, B3H 4H6
J. A. Embil*
Affiliation:
Department of Microbiology, Sir Charles Tupper Medical Building, Dalhousie University, Halifax, Nova Scotia, Canada, B3H 4H6
*
*To whom all correspondence should be addressed.
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Abstract

Third larval stages (L3) removed from fish fillets, fourth larval stages (L4) raised in in vitro culture, and adults of Pseudoterranova decipiens, collected from grey seal (Halichoerus grypus) stomachs, were exposed to the broad spectrum anthelmintic, ivermectin. L3 and L4 parasites were exposed, in vitro, to 500, 100, 50, 20, 5 and 1 μg/ml concentrations of the drug, in culture media. Adult P. decipiens were exposed in vitro to a concentration of 500 μg/ml ivermectin, only. Controls consisted of parasites placed in culture media alone or culture media plus drug vehicle. These three developmental stages of P. decipiens were all found to be susceptible to the effects of ivermectin.

Keywords

Pseudoterranova decipiensivermectinsurvivalin vitro
Type
Research Note
Information
Journal of Helminthology , Volume 63 , Issue 1 , March 1989 , pp. 72 - 74
Copyright
Copyright © Cambridge University Press 1989

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References

REFERENCES

Ibarra, O. F. & Jenkins, D. C. (1984) The relevance of in vitro anthelmintic screening tests employing the free-living stages of trichostrongylid nematodes. Journal of Helminthology, 58, 107–112.CrossRefGoogle ScholarPubMed
McClelland, G., Misra, R. K. & Marcogliese, D. J. (1983) Variations in abundance of larval Anisakines, sealworm (Phocanema decipiens) and related species in cod and flatfish from the southern Gulf of St. Lawrence (4T) and Breton Shelf (4Un). Canadian Technical Report of Fisheries and Aquatic Sciences, No. 1201.Google Scholar
Raybourne, R., Desowitz, R. S., Kliks, M. M. & Deardorff, T. L. (1983) Anisakis simplex and Terranova sp.: inhibition of larval excretory–secretory products of mitogen-induced rodent lymphoblast proliferation. Experimental Parasitology, 55, 289–298.CrossRefGoogle ScholarPubMed
Townsley, P. M., Wight, H. G., Scott, M. R. & Hughes, M. L. (1963) The in vitro maturation of the parasitic nematode, Terranova decipiens, from cod muscle. Journal of the Fisheries Research Board of Canada, 20, 743–747.CrossRefGoogle Scholar