Hostname: page-component-848d4c4894-r5zm4 Total loading time: 0 Render date: 2024-06-25T18:03:10.021Z Has data issue: false hasContentIssue false
  • English
  • Français

Echinococcus granulosus: development of resistance to albendazole in an animal model

Published online by Cambridge University Press:  05 June 2009

D. L. Morris  and
D. H. Taylor
D. L. Morris
Affiliation:
Department of Surgery, University Hospital, Nottingham, UK
D. H. Taylor
Affiliation:
Department of Surgery, University Hospital, Nottingham, UK
Get access Rights & Permissions [Opens in a new window]

Abstract

Gerbils with well developed peritoneal cysts of Echinococcus granulosus were randomized to albendazole 50 mg/kg/day or untreated control. Treated animals had less disease at post mortem after 3 months of treatment. Cysts were then taken from both albendazole-treated and control animals and cultured in vitro either with or without albendazole sulphoxide (Alb Sx) 500 μg/L for 14 days. Viability of cysts was then established by implantation of whole cysts into gerbils. Whilst naive cysts were affected by Alb Sx (only 2 cysts developed/gerbil) cysts from animals treated with albendazole were not sensitive to further therapy (6.4 cysts/gerbil).

Keywords

Echinococcus granulosusgerbilalbendazoledrug resistance
Type
Research Article
Information
Journal of Helminthology , Volume 64 , Issue 2 , June 1990 , pp. 171 - 174
Copyright
Copyright © Cambridge University Press 1990

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Chinnery, J. & Morris, D. L. (1986) Effect of albendazole sulphoxide on viability of hydatid protoscoleces. Transactions of the Royal Society of Tropical Medicine and Hygiene, 80, 815–817.CrossRefGoogle ScholarPubMed
Horton, R. J. (1989) Chemotherapy of Echinococcus infection in man with albendazole. Transactions of the Royal Society of Tropical Medicine and Hygiene, 83, 97–102.CrossRefGoogle ScholarPubMed
Morris, D. L. (1990) Albendazole treatment of hydatid disease – follow up at 5 years. Tropical Doctor (in press).Google Scholar
Morris, D. L., Chinnery, J., Georgiou, G., Stamatakis, G. & Golematis, B. (1987) Penetration of albendazole sulphoxide into hydatid cysts. Gut, 28, 75–80.CrossRefGoogle ScholarPubMed
Morris, D. L., Chinnery, J. & Hardcastle, J. D. (1986) Can albendazole reduce the risk of implantation of spilled protoscoleces? An animal study. Transactions of the Royal Society of Tropical Medicine and Hvgiene, 80, 481–484.CrossRefGoogle ScholarPubMed
Morris, D. L., Clarkson, M. J., Stallbaum, M. E, Pritchard, S., Jones, P. S. & Chinnery, J. B. (1985a) Albendazole treatment of pulmonary hydatid cysts in naturally infected sheep. A study with relevance to man. Thorax, 40, 453–458.CrossRefGoogle ScholarPubMed
Morris, D. L., Dykes, P. W., Marriner, S., Bogan, J., Burrows, F., Skeene Smith, H. & Clarkson, M. J. (1985b) Albendazole – objective evidence of response in human hydatid disease. Journal of the American Medical Association, 253, 2053–2057.CrossRefGoogle ScholarPubMed
Taylor, D. H., Morris, D. L. & Richards, K. S. (1989) E. granulosus – in vitro maintenance of whole cysts and the assessment of the effects of albendazole sulphoxide and praziquantel on the germinal layer. Transactions of the Royal Society of Tropical Medicine and Hygiene, 83, 535–539.CrossRefGoogle Scholar