Skip to main content Accessibility help

Cross-resistance between Strongyloides venezuelensis and S. ratti in mice

  • M. Korenaga (a1), Y. Hitoshi (a2), K. Takatsu (a2) and I. Tada (a3)


Cross-resistance between Strongyloides venezuelensis and S. ratti was tested in mice. The mice were immunized with S. ratti and challenged with infective filariform larvae or larvae recovered from the lungs of mice, of a heterologous species, S. venezuelensis. In this system, cross-resistance was expressed to the intestinal stage but not to the migrating stage of the parasite. Anti-interleukin (IL)-5 monoclonal antibody (mAb) treatment showed that peripheral blood eosinophilia after infection with both species of the genus Strongyloides was dependent on IL-5. Cross-resistance expressed to the intestinal stages was inhibited partially by injection of anti-IL-5 mAb.


Corresponding author

*Correspondence and present address: Department of Parasitology, Kochi Medical School, Nankoku, Kochi 783, Japan.


Hide All
Abe, T., Sugaya, H., Yoshimura, K. & Nawa, Y. (1992) Induction of the expulsion of Strongyloides ratti and retention of Nippostrongylus brasiliensis in athymic nude mice by repetitive administration of recombinant IL-3. Immunology 76, 1014.
Coffman, R.L., Shrader, B., Carty, J., Mosmann, T.R. & Bond, M.W. (1987) A mouse T cell product that preferentially enhances IgA production. I. Biologic characterization. Journal of Immunology 139, 36853690.
Dawkins, H.J.S. & Grove, D.I. (1981) Transfer by serum and cells of resistance to infection with Strongyloides ratti in mice. Immunology 43, 317322.
Dawkins, H.J.S. & Grove, D.I. (1982) Immunisation of mice against Strongyloides ratti. Zeitschrift für Parasitenkunde 66, 327333.
Harada, N., Takahashi, T., Matsumoto, M., Kinashi, T., Ohara, J., Kikuchi, Y., Koyama, N., Severinson, E., Yaoita, Y., Honjo, T., Yamaguchi, N., Tominaga, A. & Takatsu, K. (1987) Production of a monoclonal antibody useful in the molecular characterization of murine T-cell-replacing factor/B-cell growth factor II. Proceedings of the National Academy of Sciences, USA 84, 45814585.
Hasegawa, H., Orido, Y., Sato, Y. & Otsuru, M. (1988) Strongyloides venezuelensis Brumpt, 1934 (Nematoda: Strongyloididae) collected from Rattus norvegicus in Naha, Okinawa, Japan. Japanese Journal of Parasitology 37, 429434.
Khan, A.I., Horii, Y., Tiuria, R., Sato, Y. & Nawa, Y. (1993) Mucosal mast cell and the expulsive mechanisms of mice against Strongyloides venezuelensis. International Journal for Parasitology 23, 551555.
Kazakos, K.R. (1976) Increased resistance in the rat to Strongyloides ratti following immunization against Trichinella spiralis. Journal of Parasitology 62, 493494.
Kazacos, K.R. & Thorson, R.E. (1975) Cross-resistance betweenNippostrongylus brasiliensis and Strongyloides ratti in rats. Journal of Parasitology 61, 525529.
Korenaga, M., Hitoshi, Y., Takatsu, K. & Tada, I. (1994) Regulatory effect of anti-IL-5 monoclonal antibody on intestinal worm burden in a primary infection with Strongyloides venezuelensis in mice. International Journal for Parasitology 24, 951957.
Korenaga, M., Hitoshi, Y., Yamaguchi, N., Sato, Y., Takatsu, K. & Tada, I. (1991) The role of interleukin-5 in protective immunity to Strongyloides venezuelensis infection in mice. Immunology 72, 502507.
Korenaga, M., Nawa, Y., Mimori, T. & Tada, I. (1983) Strongyloides ratti: Role of enteral antigenic stimuli by adult worms in the generation of protective immunity in rats. Experimental Parasitology 55, 358363.
Little, M.D. (1961) Concurrent infections of Strongyloides venezuelensis and S. ratti in wild rats in New Orleans. Journal of Parasitology 47, 17.
Minematsu, T., Yamazaki, S., Uji, Y., Okabe, H., Korenaga, M. & Tada, I. (1990) Analysis of polyunsaturated fatty acid composition of Strongyloides ratti in relation to development. Journal of Helminthology 64, 303309.
Moqbel, R. & Wakelin, D. (1979) Trichinella spiralis and Strongyloides ratti: Immune interaction in adult rats. Experimental Parasitology 47, 6572.
Nawa, Y., Mimori, T., Korenaga, M. & Tada, I. (1982) Stage-specific cross-resistance between Nippostrongylus brasiliensis and Strongyloides ratti (Nematoda) in rats. Journal of Parasitology 68, 804808.
Northern, C. & Grove, D.I. (1988) Western blot analysis of reactivity to larval and adult Strongyloides ratti antigens in mice. Parasite Immunology 10, 681691.
Sato, Y., Inoue, F., Kiyuna, S. & Shiroma, Y. (1990) Immunoblot analysis of three antigen preparations from Strongyloides stercoralis larvae in human strongyloidiasis. Japanese Journal of Parasitology 39, 258266.
Sato, Y. & Toma, H. (1990) Effects of spleen cells and serum on transfer of immunity to Strongyloides venezuelensis infection in hypothymic (nude) mice. International Journal for Parasitology 20, 6367.
Sheldon, A.J. (1937) Studies on active acquired resistance, natural and artificial, in the rat to infection with Strongyloides ratti. American Journal of Hygiene 25, 5365.
Tada, I., Mimori, T. & Nakai, M. (1979) Migration route of Strongyloides ratti in albino rats. Japanese Journal of Parasitology 28, 219227.
Wertheim, G. & Lengy, J. (1964) The seasonal occurrence of Strongyloides ratti Sandground, 1925 and of S. venezuelensis Brumpt, 1934 in a population of Rattus norvegicus. Journal of Helminthology 38, 393398.

Cross-resistance between Strongyloides venezuelensis and S. ratti in mice

  • M. Korenaga (a1), Y. Hitoshi (a2), K. Takatsu (a2) and I. Tada (a3)


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed