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Comparative activity of anticestode drugs—praziquantel, niclosamide and Compound 77–6, against Hymenolepis nana

Published online by Cambridge University Press:  05 June 2009

Suman Gupta  and
J. C. Katiyar
Suman Gupta
Affiliation:
Division of Parasitology. Central Drug Research Institute, Lucknow 226001, India
J. C. Katiyar
Affiliation:
Division of Parasitology. Central Drug Research Institute, Lucknow 226001, India
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Abstract

The activity, in terms of speed of action, of three anticestode drugs against Hymenolepis nana, both in vivo and in vitro, was investigated. Praziquantel was most effective in vivo, but had little action on adult worms and cysticercoids in vitro. Niclosamide, the least effective in vivo, was highly toxic in vitro. Compound 77–6 killed adult worms and cysticercoids in vitro in 10 min and 15 min respectively at 1000 μg/ml of drug concentration, but its in viro effect was intermediate between that of praziquantel and niclosamide.

Type
Research Papers
Information
Journal of Helminthology , Volume 57 , Issue 1 , March 1983 , pp. 31 - 36
Copyright
Copyright © Cambridge University Press 1983

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