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Clinical and haematological characteristics of human trichostrongyliasis

Published online by Cambridge University Press:  07 February 2018

L. Ghanbarzadeh ,
M. Saraei ,
E.B. Kia ,
F. Amini  and
M. Sharifdini
L. Ghanbarzadeh
Affiliation:
Department of Medical Parasitology and Mycology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
M. Saraei
Affiliation:
Department of Medical Parasitology and Mycology, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
E.B. Kia
Affiliation:
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
F. Amini
Affiliation:
Department of Biostatistics, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
M. Sharifdini*
Affiliation:
Department of Medical Parasitology and Mycology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
*
Author for correspondence: M. Sharifdini, E-mail: sharifdini@gums.ac.ir
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Abstract

Trichostrongylus spp. are primarily parasites of ruminants, but humans can become infected as accidental hosts. Information about the clinical aspects of human trichostrongyliasis is limited. This study investigated the clinical and haematological characteristics of a large number of trichostrongyliasis patients. In the Fouman district of Guilan Province in northern Iran, during 2015–2016, 60 patients were identified as positive for Trichostrongylus spp., using stool examination methods. The clinical manifestations and demographic data of all patients were recorded and further analysed. Twenty-three patients (38.3%) were male and 37 (61.7%) were female. Among the individuals infected only with Trichostrongylus, only nine patients (16.4%) were asymptomatic. Forty-six patients (83.6%) presented with gastrointestinal (76.3%), pulmonary (30.9%) and cutaneous (12.7%) symptoms. No statistically significant relationship was found between clinical manifestations and sex or age groups. Ten patients (18.1%) revealed eosinophilia and five (9.1%) presented with hypochromic microcytic anaemia. The relationship between eosinophilia and age group, sex and clinical manifestations showed no statistical significance. Our study indicated that trichostrongyliasis may be a major parasitic aetiology for gastrointestinal symptoms and eosinophilia in rural residents of endemic areas.

Type
Research Paper
Information
Journal of Helminthology , Volume 93 , Issue 2 , March 2019 , pp. 149 - 153
Copyright
Copyright © Cambridge University Press 2018 

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References

Ahmadi, M, Kia, EB, Rezaeian, M, Hosseini, M, Kamranrashani, B and Tarighi, F (2015) Prevalence of Strongyloides stercoralis and other intestinal parasites in rehabilitation centers in Mazandaran Province, northern Iran. Journal of Mazandaran University of Medical Sciences 25, 1–7.Google Scholar
Ashrafi, K, Tahbaz, A, Sharifdini, M and Mas-Coma, S (2015) Familial Trichostrongylus infection misdiagnosed as acute fascioliasis. Emerging Infectious Diseases 21, 1869–1870.Google Scholar
Boreham, RE, McCowan, MJ, Ryan, AE, Allworth, AM and Robson, JM (1995) Human trichostrongyliasis in Queensland. Pathology 27, 182–185.Google Scholar
Buonfrate, D, Angheben, A, Gobbi, F, Mistretta, M, Degani, M and Bisoffi, Z (2017) Four clusters of Trichostrongylus infection diagnosed in a single center, in Italy. Infection 45, 233–236.Google Scholar
Chim, CS, Luk, WK and Yuen, KY (1997) Trichostrongylus infestation masquerading as conditioning toxicity of the gut in bone marrow transplantation. Bone Marrow Transplant 19, 955–956.Google Scholar
Garcia, LS (2007) Diagnostic medical parasitology. Washington DC, ASM Press.Google Scholar
Ghadirian, E (1977) Human infection with Trichostrongylus lerouxi (Biocca, Chabaud, and Ghadirian, 1974) in Iran. American Journal of Tropical Medicine and Hygiene 26, 1212–1213.Google Scholar
Ghadirian, E and Arfaa, F (1975) Present status of trichostrongyliasis in Iran. American Journal of Tropical Medicine and Hygiene 24, 935–941.Google Scholar
Ghadirian, E, Arfaa, F and Sadighian, A (1974) Human infection with Trichostrongylus capricola in Iran. American Journal of Tropical Medicine and Hygiene 23, 1002–1003.Google Scholar
Gholami, S, Babamahmoodi, F, Abedian, R, Sharif, M, Shahbazi, A, Pagheh, A and Fakhar, M (2015) Trichostrongylus colubriformis: possible most common cause of human infection in Mazandaran Province, north of Iran. Iranian Journal of Parasitology 10, 110–115.Google Scholar
Gotuzzo, E, Terashima, A, Alvarez, H, Tello, R, Infante, R, Watts, DM and Freedman, DO (1999) Strongyloides stercoralis hyperinfection associated with human T cell lymphotropic virus type-1 infection in Peru. American Journal of Tropical Medicine and Hygiene 60, 146–149.Google Scholar
Kazemi Rad, L and Mohammadi, H (2015) Climate change assessment in Gilan province, Iran. International Journal of Agriculture and Crop Sciences 8, 86–93.Google Scholar
Kia, EB, Mahmoudi, M, Zahabiun, F and Meamar, AR (2007) An evaluation on the efficacy of agar plate culture for detection of Strongyloides stercoralis. Iranian Journal of Parasitology 2, 29–34.Google Scholar
Lattes, S, Ferte, H, Delaunay, P, Depaquit, J, Vassallo, M, Vittier, M, Kokcha, S, Coulibaly, E and Marty, P (2011) Trichostrongylus colubriformis nematode infections in humans, France. Emerging Infectious Diseases 17, 1301–1302.Google Scholar
Phosuk, I, Intapan, PM, Sanpool, O, Janwan, P, Thanchomnang, T, Sawanyawisuth, K, Morakote, N and Maleewong, W (2013) Molecular evidence of Trichostrongylus colubriformis and Trichostrongylus axei infections in humans from Thailand and Lao PDR. American Journal of Tropical Medicine and Hygiene 89, 376–379.Google Scholar
Phosuk, I, Intapan, PM, Prasongdee, TK, Changtrakul, Y, Sanpool, O, Janwan, P and Maleewong, W (2015) Human trichostrongyliasis: a hospital case series. Southeast Asian Journal of Tropical Medicine and Public Health 46, 191–197.Google Scholar
Ralph, A, O'Sullivan, MV, Sangster, NC and Walker, JC (2006) Abdominal pain and eosinophilia in suburban goat keepers – trichostrongylosis. Medical Journal of Australia 184, 467–469.Google Scholar
Roberts, LS and Janovy, J (2012) Foundations of parasitology. 8th edn. New York, McGraw-Hill.Google Scholar
Rokni, MB (2008) The present status of human helminthic diseases in Iran. Annals of Tropical Medicine and Parasitology 102, 283–295.Google Scholar
Sharifdini, M, Kia, EB, Ashrafi, K, Hosseini, M, Mirhendi, H, Mohebali, M and Kamranrashani, B (2014) An analysis of clinical characteristics of Strongyloides stercoralis in 70 indigenous patients in Iran. Iranian Journal of Parasitology 9, 155–162.Google Scholar
Sharifdini, M, Mirhendi, H, Ashrafi, K, Hosseini, M, Mohebali, M, Khodadadi, H and Kia, EB (2015) Comparison of nested polymerase chain reaction and real-time polymerase chain reaction with parasitological methods for detection of Strongyloides stercoralis in human fecal samples. American Journal of Tropical Medicine and Hygiene 93, 1285–1291.Google Scholar
Sharifdini, M, Derakhshani, S, Alizadeh, SA, Ghanbarzadeh, L, Mirjalali, H, Mobedi, I and Saraei, M (2017a) Molecular identification and phylogenetic analysis of human Trichostrongylus species from an endemic area of Iran. Acta Tropica 176, 293–299.Google Scholar
Sharifdini, M, Ghanbarzadeh, L, Kouhestani-Maklavani, N, Mirjalali, H and Saraei, M (2017b) Prevalence and molecular aspects of human hookworms in Guilan province, northern Iran. Iranian Journal of Parasitology 12, 374–381.Google Scholar
Sharifdini, M, Heidari, Z, Hesari, Z, Vatandoost, S and Kia, EB (2017c) Molecular phylogenetics of Trichostrongylus species (Nematoda: Trichostrongylidae) from humans of Mazandaran Province, Iran. Korean Journal of Parasitology 55, 279–285.Google Scholar
Thibert, JB, Guiguen, C and Gangneux, JP (2006) Human trichostrongyloidosis: case report and microscopic difficulties to identify Ankylostomidae eggs. Annales De Biologie Clinique 64, 281–285.Google Scholar
Wall, EC, Bhatnagar, N, Watson, J and Doherty, T (2011) An unusual case of hypereosinophilia and abdominal pain: an outbreak of Trichostrongylus imported from New Zealand. Journal of Travel Medicine 18, 59–60.Google Scholar
Wallace, L, Henkin, R and Mathies, AW (1956) Trichostrongylus infestation with profound eosinophilia. Annals of Internal Medicine 45, 146–150.Google Scholar
Watthanakulpanich, D, Pongvongsa, T, Sanguankiat, S, et al. (2013) Prevalence and clinical aspects of human Trichostrongylus colubriformis infection in Lao PDR. Acta Tropica 126, 37–42.Google Scholar
Wolfe, MS (1978) Oxyuris, Trichostrongylus and Trichuris. Journal of Clinical Gastroenterology 7, 201–217.Google Scholar