Skip to main content Accessibility help
×
Home
Hostname: page-component-559fc8cf4f-55wx7 Total loading time: 0.51 Render date: 2021-03-05T13:15:10.068Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": false, "newCiteModal": false, "newCitedByModal": true }

Attempts to manipulate specific responses to induce resistance to Schistosoma mansoni in Kenyan baboons (Papio anubis)

Published online by Cambridge University Press:  18 November 2009

R. F. Sturrock
Affiliation:
Department of Medical Ilelminthology, London School of Hygiene and Tropical Medicine, Keppel Street (Gower Street), London WCIE E 7H T, England
A. E. Butterworth
Affiliation:
Department of Medical Ilelminthology, London School of Hygiene and Tropical Medicine, Keppel Street (Gower Street), London WCIE E 7H T, England
V. Houba
Affiliation:
Department of Medical Ilelminthology, London School of Hygiene and Tropical Medicine, Keppel Street (Gower Street), London WCIE E 7H T, England
B. J. cottrell
Affiliation:
Department of Medical Ilelminthology, London School of Hygiene and Tropical Medicine, Keppel Street (Gower Street), London WCIE E 7H T, England
R. Kimani
Affiliation:
Department of Medical Ilelminthology, London School of Hygiene and Tropical Medicine, Keppel Street (Gower Street), London WCIE E 7H T, England
M. Joseph
Affiliation:
Department of Medical Ilelminthology, London School of Hygiene and Tropical Medicine, Keppel Street (Gower Street), London WCIE E 7H T, England
A. Capron
Affiliation:
Department of Medical Ilelminthology, London School of Hygiene and Tropical Medicine, Keppel Street (Gower Street), London WCIE E 7H T, England
R. Ramasamy
Affiliation:
Department of Medical Ilelminthology, London School of Hygiene and Tropical Medicine, Keppel Street (Gower Street), London WCIE E 7H T, England
J. Shah
Affiliation:
Department of Medical Ilelminthology, London School of Hygiene and Tropical Medicine, Keppel Street (Gower Street), London WCIE E 7H T, England

Abstract

Attempts were made to manipulate specific responses of baboons to protect them from infection with Schistosoma mansoni. In Experiment 1, cosinophilia was induced in naive baboons with Trichinella spiralis larvae given intravenously before intraperitoneal injection of globulin fractions from S. mansoni-infected baboon sera and subsequent percutancous exposure to S. mansoni cercariac. In Experiment 2, baboons with 8- or 32-week-old primary S. mansoni infections received T spiralis i.v. before an S. mansoni challenge. In experiments 3 to 5 respectively, naive baboons received intramuscularly before challenge: formalin-fixed S. mansoni schistosomula, with Bordetella pertussis as an adjuvant; a preparation of S. mansoni adult worm teguments; and a preparation of NE-immune complexes obtained from S. mansoni-infected rat sera, with Freunds Complete Adjuvant. Minor, but statistically insignificant, protection was obtained in Experiments 2 (32-week infections) and 3, but was far less than that given by intact, irradiated living vaccines. There are signs on the horizon of non-living vaccines protecting rodents against S. mansoni infection and it would be prudent, as with drugs, to test these in primates before proceeding to man. The results of our experiments, though essentially negative, should help the design of any future vaccine trials in primates.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1985

Access options

Get access to the full version of this content by using one of the access options below.

References

Bushara, H. O., Hussein, M. F., Saad, A. M., Taylor, M. G., Dargie, J. D., Marshall, T. F. DEC. & Nelson, G. S. (1978) Immunisation of calves against Schistosoma bovis using irradiated ccrcariae or schistosomula of S. bovis. Parasitology, 77, 303311.CrossRefGoogle Scholar
Butterworth, A. E., Sturrock, R. F., Houba, V. & Taylor, R. (1976) Schistosoma mansoni in baboons: antibody-dependent cell-mediated damage to 51Cr-labelled schistosomula. Clinical and Experimental Immunology, 25, 95102.Google Scholar
Butterworth, A. E., Taylor, D. W., Vieth, M. C., Vadas, M. A., Dessein, A., Sturrock, R. F. & Wells, E. (1982) Studies on the mechanisms of immunity in human schistosomiasis. Immunological Reviews, 61, 539.CrossRefGoogle Scholar
Capron, A., Dessaint, J. P., Joseph, M., Rousseaux, R., Capron, M. & Bazin, H. (1977) Interaction between IgE complexes and macrophages in the rat: a new mechanism of macrophage activation. European Journal of Immunology, 7, 315322.CrossRefGoogle Scholar
Capron, A., Dessaint, J. P., Joseph, M., Torpier, G., Capron, M., Rousseaux, R., Santoro, F. & Bazin, H. (1977) IgE and cells in schistosomiasis. American Journal of Tropical Medicine and Hygiene, 26, 3947.CrossRefGoogle Scholar
Damian, R. T., Greene, N. D., Meyer, K. F., Cheever, A. N., Hubbard, W. J., Hawes, M. E., & Clark, J. D. (1976) Schistosoma mansoni in baboons. III. The course and characteristics of infection with additional observations on immunity. American Journal of Tropical Medicine and Hygiene, 25, 299306.CrossRefGoogle Scholar
Houba, V., Koech, D. K., Sturrock, R. F., Butterworth, A. E., Kusel, J. & Mahmoud, A. A. F. (1976) Soluble antigens and antibodies in sera from baboons infected with Schistosoma mansoni. Journal of Immunology, 117, 705707.Google Scholar
Kimani, R. G. (1981) In vitro antibody-dependent cell mediated mechanisms in Kenyan baboons (Papio anubis) towards schistosomula of Schistosoma mansoni. MSc Thesis, University of Nairobi, Kenya.Google Scholar
Kusel, J. R. (1972) Protein composition and protein synthesis in the surface membranes of Schistosoma mansoni. Parasitology, 65, 5569.CrossRefGoogle Scholar
Mclaren, D. J. (1980) Schistosoma mansoni: the parasite surface in relation to immunity. Research studies Press, John Wiley & Sons, Chichester, UK.Google Scholar
Playfair, J. H. C., De Souza, J. B. & Cottrell, B. J. (1977) Protection of mice against malaria by a killed vaccine: differences in effectiveness against Plasmodium yoelii and P. berghei. Immunology, 33, 507515.Google Scholar
Ramalho-Pinto, F. J., Gallinelli, G., Howells, R. E., Mota-Santos, T. A., Figueiredo, E. A. & Pellegrino, J. (1974) Schistosoma mansoni: defined system for stepwise transformation of cercariac into schistosomula in vitro. Experimental Parasitology, 36, 360372.CrossRefGoogle Scholar
Shah, J. & Ramasamy, R. (1981) Schistosoma mansoni: common antigens on adult worm tegument and cercariac detected by immunodiffusion. East African Medical Journal, 58, 330333.Google Scholar
Shah, J. & Ramasamy, R. (1982) Surface antigens on cercariac, schistosomula and adult worms of Schistosoma mansoni. International Journal for Parasitology, 12, 451461.CrossRefGoogle Scholar
Snary, D., Smith, M. A. & Clegg, J. (1980) Surface proteins of Schistosoma mansoni and their expression during morphogcncsis. European Journal of Immunology, 10, 573575.CrossRefGoogle Scholar
Snedecor, G. W. & Cochran, W. G. (1967) Statistical Methods (6th edition). State University Press: Ames, Iowa, 593 pp.Google Scholar
Stek, M., Minard, P., Dean, D. A. & Hall, J. E. (1981) Immunisation of baboons with Schistosoma mansoni cercariac attenuated by gamma irradiation. Science (Washington), 212, 15181520.CrossRefGoogle Scholar
Sturrock, R. F., Butterworth, A. E. & Houba, V. (1976) Schistosoma mansoni in the baboon (Papio anubis): parasitological responses of Kenyan baboons to different exposures of a local parasite strain. Parasitology, 73, 239252.CrossRefGoogle Scholar
Sturrock, R. F., Butterworth, A. E., Houba, V., Karamsadkar, S. D. & Kimani, R. (1978) Schistosoma mansoni in the Kenyan baboon (Papio anubis): the development and predictability of resistance to homologous challenge. Transactions of the Royal Society of Tropical Medicine and Hygiene, 72, 251261.CrossRefGoogle Scholar
Sturrock, R. F., Butterworth, A. E., Karamsadkar, S. D., Kimani, R., Imbuga, M. & Houba, V. (1977) Eosionophilia in Kenyan baboons (Papio anubis) induced by Trichinella spiralis and Schistosoma mansoni. Parasitology, 75, 89100.CrossRefGoogle Scholar
Sturrock, R. F., Cottrell, B. J. & Kimani, R. (1984) Observations on the ability of repeated light exposures to Schistosoma mansoni cercariac to induce resistance to reinfection in Kenyan baboons (Papio anubis). Parasitology, 88, 505514.CrossRefGoogle Scholar
Sturrock, R. F., Cottrell, B. J., Mahmoud, A. A. F., Chedid, L. & Kimani, R. (1985) Attempts to induce resistance to Schistosoma mansoni and S. haematobium in Kenyan baboons (Papio anubis) using non-specific immunostimulants. Parasitology, 90, 101110.CrossRefGoogle Scholar
Sturrock, R. F., James, E. R. & WEBBE, G. (1980) Immunisation of baboons (Papio anubis) against Schistosoma haematobium with irradiated cercariae or schistosomula. Transactions of the Royal Society of Tropical Medicine and Hygiene, 74, 834835.CrossRefGoogle Scholar
Taylor, D. W., Hayunga, E. G. & Vannier, W. E. (1981) Surface antigens of Schistosoma mansoni. Molecular and Biochemical Parasitology, 3, 157161.CrossRefGoogle Scholar
Taylor, M. G., Nelson, G. S., Smith, M. & Andrews, B. J. (1973) Studies on heterologous immunity in schistosomiasis. 7. Observations on the development of acquired homologous immunity to Schistosoma mansoni in baboons. Bulletin of the World Health Organization, 49, 5765.Google Scholar
Vadas, M. A., David, J. R., Butterworth, A. E., Pisani, N. T. & Siongok, T. A. (1979) A new method for the purification of human cosinophils and neutrophils, and a comparison of the ability of these cells to damage schistosomula of Schistosoma mansoni. Journal of Immunology, 122, 12281236.Google Scholar
Webbe, G., Sturrock, R. F., James, E R. & James, C. (1982) Schistosoma haematobium in the baboon (Papio anubis): effect of vaccination with irradiated larvae on the subsequent infection with percutaneously applied cercariae. Transactions of the Royal Society of Tropical Medicine and Hygiene, 76, 354361.CrossRefGoogle Scholar
Weir, D. M. (1967) Handbook of experimental immunology. Blackwell Scientific Publications: Oxford, UK.Google Scholar
Who Memorandum (1974) Immunology of Schistosomiasis. Bulletin of the World Health Organization, 51, 553595.Google Scholar
Wilson, R. A. (1980) Is immunity to Schistosoma mansoni in the chronically infected laboratory mouse an artefact of pathology? In: Proceedings of the third multicolloqulum of Parasitology,Cambridge,European Federation of Parasitologists. p. 37.Google Scholar
Wilson, R. A., Coulson, P. S. & Mchugh, S. M. (1983) A significant part of the ‘concomitant immunity’ of mice to Schistosoma mansoni is the consequence of a leaky hepatic portal system, not immune killing. Parasite Immunology, 5, 595601.CrossRefGoogle Scholar

Full text views

Full text views reflects PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views.

Total number of HTML views: 0
Total number of PDF views: 5 *
View data table for this chart

* Views captured on Cambridge Core between September 2016 - 5th March 2021. This data will be updated every 24 hours.

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Attempts to manipulate specific responses to induce resistance to Schistosoma mansoni in Kenyan baboons (Papio anubis)
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Attempts to manipulate specific responses to induce resistance to Schistosoma mansoni in Kenyan baboons (Papio anubis)
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Attempts to manipulate specific responses to induce resistance to Schistosoma mansoni in Kenyan baboons (Papio anubis)
Available formats
×
×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *