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Supplemental folic acid and/or multivitamins in pregnancy is associated with a decreased risk of childhood and adolescent nasopharyngeal carcinoma

Published online by Cambridge University Press:  15 November 2021

Yue Yan ,
Chuanbo Xie ,
Shi Di ,
Zhonghao Wang ,
Minqing Wu ,
Yanhong Li ,
Yuying Liu  and
Rou Jiang Open the ORCID record for Rou Jiang [Opens in a new window]
Yue Yan
Affiliation:
Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China
Chuanbo Xie
Affiliation:
Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China
Shi Di
Affiliation:
Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China
Zhonghao Wang
Affiliation:
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China
Minqing Wu
Affiliation:
Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China
Yanhong Li
Affiliation:
Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China
Yuying Liu*
Affiliation:
Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China
Rou Jiang*
Affiliation:
Cancer Prevention Center, Sun Yat-sen University Cancer Center, Guangzhou, P. R. China State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Collaborative Innovation Center for Cancer Medicine, Guangzhou, P. R. China
*
Address for correspondence: Rou Jiang, Cancer Prevention Center, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P. R. China. Email: jiangrou@sysucc.org.cn; Yuying Liu, Cancer Prevention Center, Sun Yat-sen University Cancer Center, 651Dongfeng Road East, Guangzhou 510060, P. R. China. Email: liuyy@sysucc.org.cn
Address for correspondence: Rou Jiang, Cancer Prevention Center, Sun Yat-sen University Cancer Center, 651 Dongfeng Road East, Guangzhou 510060, P. R. China. Email: jiangrou@sysucc.org.cn; Yuying Liu, Cancer Prevention Center, Sun Yat-sen University Cancer Center, 651Dongfeng Road East, Guangzhou 510060, P. R. China. Email: liuyy@sysucc.org.cn
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Abstract

The aim of this study was to evaluate the association between prenatal and neonatal period exposures and the risk of childhood and adolescent nasopharyngeal carcinoma (NPC). From January 2009 to January 2016, a total of 46 patients with childhood and adolescent NPC (i.e., less than 18 years of age) who were treated at Sun Yat-sen University Cancer Center were screened as cases, and a total of 45 cancer-free patients who were treated at Sun Yat-sen University Zhongshan Ophthalmic Center were selected as controls. The association between maternal exposures during pregnancy and obstetric variables and the risk of childhood and adolescent NPC was evaluated using logistic regression analysis. Univariate analysis revealed that compared to children and adolescents without a family history of cancer, those with a family history of cancer had a significantly higher risk of childhood and adolescent NPC [odds ratios (OR) = 3.15, 95% confidence interval (CI) = 1.02–9.75, P = 0.046], and the maternal use of folic acid and/or multivitamins during pregnancy was associated with a reduced risk of childhood and adolescent NPC in the offspring (OR = 0.07, 95% CI = 0.02–0.25, P < 0.001). After multivariate analysis, only the maternal use of folic acid and/or multivitamins during pregnancy remained statistically significant. These findings suggest that maternal consumption of folic acid and/or multivitamins during pregnancy is associated with a decreased risk of childhood and adolescent NPC in the offspring.

Keywords

Folic acidmultivitaminspregnancychildhood and adolescent NPC risk
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 13 , Issue 5 , October 2022 , pp. 550 - 555
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Copyright
© The Author(s), 2021. Published by Cambridge University Press in association with International Society for Developmental Origins of Health and Disease

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Footnotes

Yue Yan and Chuanbo Xie are contributed equally to this paper.

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