Bateson, P, Gluckman, P, Hanson, M. The biology of developmental plasticity and the predictive adaptive response hypothesis. J Physiol. 2014; 592(Pt 11), 2357–2368.
Braddick, LM, Burrage, DM, Cleal, JK, et al. The lack of impact of peri-implantation or late gestation nutrient restriction on ovine fetal renal development and function. J Dev Orig Health Dis. 2011; 2, 236–249.
Burrage, DM, Braddick, L, Cleal, JK, et al. The late gestation fetal cardiovascular response to hypoglycaemia is modified by prior peri-implantation undernutrition in sheep. J Physiol. 2009; 587(Pt 3), 611–624.
Cleal, JK, Poore, KR, Boullin, JP, et al. Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood. Proc Natl Acad Sci USA. 2007; 104, 9529–9533.
Edwards, LJ, Simonetta, G, Owens, JA, Robinson, JS, McMillen, IC. Restriction of placental and fetal growth in sheep alters fetal blood pressure responses to angiotensin II and captopril. J Physiol (Lond). 1999; 515(Pt 3), 897–904.
Edwards, LJ, McMillen, IC. Periconceptional nutrition programs development of the cardiovascular system in the fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2002; 283, R669–R679.
Hawkins, P, Steyn, C, Ozaki, T, et al. Effect of maternal undernutrition in early gestation on ovine fetal blood pressure and cardiovascular reflexes. Am J Physiol. 2000; 279, R340–R348.
Hawkins, P, Steyn, C, McGarrigle, HH, et al. Cardiovascular and hypothalamic-pituitary-adrenal axis development in late gestation fetal sheep and young lambs following modest maternal nutrient restriction in early gestation. Reprod Fertil Dev. 2000; 12, 443–456.
Torrens, C, Snelling, TH, Chau, R, et al. Effects of pre- and periconceptional undernutrition on arterial function in adult female sheep are vascular bed dependent. Exp Physiol. 2009; 94, 1024–1033.
Costello, PM, Rowlerson, A, Astaman, NA, et al. Peri-implantation and late gestation maternal undernutrition differentially affect fetal sheep skeletal muscle development. J Physiol. 2008; 586, 2371–2380.
Lie, S, Morrison, JL. Impact of periconceptional and preimplantation undernutrition on factors regulating myogenesis and protein synthesis in muscle of singleton and twin fetal sheep. Physiol Rep. 2015; 3, e12495.
Lie, S, Morrison, JL, Williams-Wyss, O, et al. Periconceptional undernutrition programs changes in insulin-signaling molecules and microRNAs in skeletal muscle in singleton and twin fetal sheep. Biol Reprod. 2014; 90, 5.
Liu, NQ, Hewison, M. Vitamin D, the placenta and pregnancy. Arch Biochem Biophys. 2012; 523, 37–47.
Salle, BL, Delvin, EE, Lapillonne, A, Bishop, NJ, Glorieux, FH. Perinatal metabolism of vitamin D. Am J Clin Nutr. 2000; 71(Suppl. 5), 1317S–1324S.
Ross, R, Halbert, K, Tsang, RC. Determination of the production and metabolic clearance rates of 1,25-dihydroxyvitamin D3 in the pregnant sheep and its chronically catheterized fetus by primed infusion technique. Pediatr Res. 1989; 26, 633–638.
Hollis, BW, Wagner, CL. Vitamin D and pregnancy: skeletal effects, nonskeletal effects, and birth outcomes. Calcif Tissue Int. 2013; 92, 128–139.
Eyles, D, Burne, T, McGrath, J. Vitamin D in fetal brain development. Semin Cell Dev Biol. 2011; 22, 629–636.
Kovacs, CS. Bone development and mineral homeostasis in the fetus and neonate: roles of the calciotropic and phosphotropic hormones. Physiol Rev. 2014; 94, 1143–1218.
Wang, Y, Zhu, J, DeLuca, HF. Where is the vitamin D receptor?
Arch Biochem Biophys. 2012; 523, 123–133.
Pilz, S, Tomaschitz, A, Marz, W, et al. Vitamin D, cardiovascular disease and mortality. Clin Endocrinol (Oxf). 2011; 75, 575–584.
Girgis, CM, Mokbel, N, Minn, CK, et al. The vitamin D receptor (VDR) is expressed in skeletal muscle of male mice and modulates 25-hydroxyvitamin D (25OHD) uptake in myofibers. Endocrinology. 2014; 155, 3227–3237.
Pludowski, P, Holick, MF, Pilz, S, et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality – a review of recent evidence. Autoimmun Rev. 2013; 12, 976–989.
Mahon, P, Harvey, N, Crozier, S, et al. Low maternal vitamin D status and fetal bone development: cohort study. J Bone Miner Res. 2010; 25, 14–19.
Dror, DK, Allen, LH. Vitamin D inadequacy in pregnancy: biology, outcomes, and interventions. Nutr Rev. 2010; 68, 465–477.
Tare, M, Emmett, SJ, Coleman, HA, et al. Vitamin D insufficiency is associated with impaired vascular endothelial and smooth muscle function and hypertension in young rats. J Physiol. 2011; 589(Pt 19), 4777–4786.
Morris, GS, Zhou, Q, Hegsted, M, Keenan, MJ. Maternal consumption of a low vitamin D diet retards metabolic and contractile development in the neonatal rat heart. J Mol Cell Cardiol. 1995; 27, 1245–1250.
Gezmish, O, Tare, M, Parkington, HC, et al. Maternal vitamin D deficiency leads to cardiac hypertrophy in rat offspring. Reprod Sci. 2010; 17, 168–176.
Harvey, NC, Moon, RJ, Sayer, AA, et al. Maternal antenatal vitamin D status and offspring muscle development: findings from the Southampton Women’s Survey. J Clin Endocrinol Metab. 2014; 99, 330–337.
Crozier, SR, Harvey, NC, Inskip, HM, et al. Maternal vitamin D status in pregnancy is associated with adiposity in the offspring: findings from the Southampton Women’s Survey. Am J Clin Nutr. 2012; 96, 57–63.
Lewis, RM, Cleal, JK, Hanson, MA. Review: placenta, evolution and lifelong health. Placenta. 2012; 33(Suppl.), S28–S32.
Liu, NQ, Ouyang, Y, Bulut, Y, et al. Dietary vitamin D restriction in pregnant female mice is associated with maternal hypertension and altered placental and fetal development. Endocrinology. 2013; 154, 2270–2280.
O’Brien, KO, Li, S, Cao, C, et al. Placental CYP27B1 and CYP24A1 expression in human placental tissue and their association with maternal and neonatal calcitropic hormones. J Clin Endocrinol Metab. 2014; 99, 1348–1356.
Young, BE, Cooper, EM, McIntyre, AW, et al. Placental vitamin D receptor (VDR) expression is related to neonatal vitamin D status, placental calcium transfer, and fetal bone length in pregnant adolescents. FASEB J. 2014; 28, 2029–2037.
Nguyen, TP, Yong, HE, Chollangi, T, et al. Placental vitamin D receptor expression is decreased in human idiopathic fetal growth restriction. J Mol Med. 2015; 93, 795–805.
Knabl, J, Huttenbrenner, R, Hutter, S, et al. Gestational diabetes mellitus upregulates vitamin D receptor in extravillous trophoblasts and fetoplacental endothelial cells. Reprod Sci. 2015; 22, 358–366.
Hiden, U, Glitzner, E, Hartmann, M, Desoye, G. Insulin and the IGF system in the human placenta of normal and diabetic pregnancies. J Anat. 2009; 215, 60–68.
Calle, C, Maestro, B, Garcia-Arencibia, M. Genomic actions of 1,25-dihydroxyvitamin D3 on insulin receptor gene expression, insulin receptor number and insulin activity in the kidney, liver and adipose tissue of streptozotocin-induced diabetic rats. BMC Mol Biol. 2008; 9, 65.
Maestro, B, Davila, N, Carranza, MC, Calle, C. Identification of a vitamin D response element in the human insulin receptor gene promoter. J Steroid Biochem Mol Biol. 2003; 84, 223–230.
Cetin, I. Placental transport of amino acids in normal and growth-restricted pregnancies. Eur J Obstet Gynecol Reprod Biol. 2003; 110(Suppl. 1), S50–S54.
Cleal, JK, Lewis, RM. The mechanisms and regulation of placental amino acid transport to the human foetus. J Neuroendocrinol. 2008; 20, 419–426.
Cleal, JK, Day, PE, Simner, CL, et al. Placental amino acid transport may be regulated by maternal vitamin D and vitamin D-binding protein: results from the Southampton Women’s Survey. Br J Nutr. 2015; 113, 1903–1910.
Quandt, K, Frech, K, Karas, H, Wingender, E, Werner, T. MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res. 1995; 23, 4878–4884.
Ramagopalan, SV, Heger, A, Berlanga, AJ, et al. A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Genome Res. 2010; 20, 1352–1360.
Magnusson-Olsson, AL, Hamark, B, Ericsson, A, et al. Gestational and hormonal regulation of human placental lipoprotein lipase. J Lipid Res. 2006; 47, 2551–2561.
Qiao, L, Guo, Z, Bosco, C, et al. Maternal high-fat feeding increases placental lipoprotein lipase activity by reducing SIRT1 expression in mice. Diabetes. 2015; 64, 3111–3120.
Huang, Y, Li, X, Wang, M, et al. Lipoprotein lipase links vitamin D, insulin resistance, and type 2 diabetes: a cross-sectional epidemiological study. Cardiovasc Diabetol. 2013; 12, 17.
Vu, D, Ong, JM, Clemens, TL, Kern, PA. 1,25-dihydroxyvitamin D induces lipoprotein lipase expression in 3T3-L1 cells in association with adipocyte differentiation. Endocrinology. 1996; 137, 1540–1544.
Bey, L, Etienne, J, Tse, C, et al. Cloning, sequencing and structural analysis of 976 base pairs of the promoter sequence for the rat lipoprotein lipase gene. Comparison with the mouse and human sequences. Gene. 1998; 209, 31–38.
49. Agricultural and Food Research Council. Energy and Protein Requirements of Ruminants. AFRC: Wallingford, UK, 1993.
Vatnick, I, Schoknecht, PA, Darrigrand, R, Bell, AW. Growth and metabolism of the placenta after unilateral fetectomy in twin pregnant ewes. J Dev Physiol. 1991; 15, 351–356.
Zhang, S, Barker, P, Botting, KJ, et al. Early restriction of placental growth results in placental structural and gene expression changes in late gestation independent of fetal hypoxemia. Physiol Rep. 2016; 4, e13049.
Heymann, MA, Payne, BD, Hoffman, JI, Rudolph, AM. Blood flow measurements with radionuclide-labeled particles. Prog Cardiovasc Dis. 1977; 20, 55–79.
Thein, E, Raab, S, Harris, AG, et al. Comparison of regional blood flow values measured by radioactive and fluorescent microspheres. Eur Surg Res. 2002; 34, 215–223.
Snellman, G, Melhus, H, Gedeborg, R, et al. Determining vitamin D status: a comparison between commercially available assays. PLoS One. 2010; 5, e11555.
Owens, DJ, Webber, D, Impey, SG, et al. Vitamin D supplementation does not improve human skeletal muscle contractile properties in insufficient young males. Eur J Appl Physiol. 2014; 114, 1309–1320.
Bustin, SA, Benes, V, Garson, JA, et al. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem. 2009; 55, 611–622.
Paulson, SK, DeLuca, HF, Battaglia, F. Plasma levels of vitamin D metabolites in fetal and pregnant ewes. Proc Soc Exp Biol Med. 1987; 185, 267–271.
Horst, RL, Littledike, ET, Riley, JL, Napoli, JL. Quantitation of vitamin D and its metabolites and their plasma concentrations in five species of animals. Anal Biochem. 1981; 116, 189–203.
Dittmer, KE, Thompson, KG. Vitamin D metabolism and rickets in domestic animals: a review. Vet Pathol. 2011; 48, 389–407.
60. National Research Council of the National Academies. Nutrient Requirements of Small Ruminants: Sheep, Goats, Cervids, and New World Camilids. 2007. National Academies Press: Washington, DC.
Japelt, RB, Jakobsen, J. Vitamin D in plants: a review of occurrence, analysis, and biosynthesis. Front Plant Sci. 2013; 4, 136.
Moniz, CF, Nicolaides, KH, Tzannatos, C, Rodeck, CH. Calcium homeostasis in second trimester fetuses. J Clin Pathol. 1986; 39, 838–841.
Harrington, J, Perumal, N, Al, MA, Baqui, A, Roth, DE. Vitamin D and fetal-neonatal calcium homeostasis: findings from a randomized controlled trial of high-dose antenatal vitamin D supplementation. Pediatr Res. 2014; 76, 302–309.
Anderson, PH, O’Loughlin, PD, May, BK, Morris, HA. Quantification of mRNA for the vitamin D metabolizing enzymes CYP27B1 and CYP24 and vitamin D receptor in kidney using real-time reverse transcriptase- polymerase chain reaction. J Mol Endocrinol. 2003; 31, 123–132.
Gernand, AD, Bodnar, LM, Klebanoff, MA, Parks, WT, Simhan, HN. Maternal serum 25-hydroxyvitamin D and placental vascular pathology in a multicenter US cohort. Am J Clin Nutr. 2013; 98, 383–388.
Naftel, J, Carr, DJ, Aitken, RP, et al. The effect of adenovirus-VEGF gene therapy on placental nutrient transport mechanisms in an ovine model of intrauterine growth restriction. Proceedings of the Physiological Society, 2014, 37th Congress of IUPS (Birmingham, UK) (2013) Proc 37th IUPS.
Cleal, JK, Glazier, JD, Ntani, G, et al. Facilitated transporters mediate net efflux of amino acids to the fetus across the basal membrane of the placental syncytiotrophoblast. J Physiol. 2011; 589(Pt 4), 987–997.
Carlberg, C, Campbell, MJ. Vitamin D receptor signaling mechanisms: integrated actions of a well-defined transcription factor. Steroids. 2013; 78, 127–136.
Girgis, CM, Clifton-Bligh, RJ, Hamrick, MW, Holick, MF, Gunton, JE. The roles of vitamin D in skeletal muscle: form, function, and metabolism. Endocr Rev. 2013; 34, 33–83.
Girgis, CM, Clifton-Bligh, RJ, Mokbel, N, Cheng, K, Gunton, JE. Vitamin D signaling regulates proliferation, differentiation, and myotube size in C2C12 skeletal muscle cells. Endocrinology. 2014; 155, 347–357.
Endo, I, Inoue, D, Mitsui, T, et al. Deletion of vitamin D receptor gene in mice results in abnormal skeletal muscle development with deregulated expression of myoregulatory transcription factors. Endocrinology. 2003; 144, 5138–5144.
Alami-Durante, H, Cluzeaud, M, Bazin, D, Mazurais, D, Zambonino-Infante, JL. Dietary cholecalciferol regulates the recruitment and growth of skeletal muscle fibers and the expressions of myogenic regulatory factors and the myosin heavy chain in European sea bass larvae. J Nutr. 2011; 141, 2146–2151.
Ceglia, L, Harris, SS. Vitamin D and its role in skeletal muscle. Calcif Tissue Int. 2012; 92, 151–162.
Polly, P, Tan, TC. The role of vitamin D in skeletal and cardiac muscle function. Front Physiol. 2014; 5, 145.
Razzaque, MS. The dualistic role of vitamin D in vascular calcifications. Kidney Int. 2011; 79, 708–714.
Valdivielso, JM, Coll, B, Fernandez, E. Vitamin D and the vasculature: can we teach an old drug new tricks?
Expert Opin Ther Targets. 2009; 13, 29–38.
Grundmann, M, Haidar, M, Placzko, S, et al. Vitamin D improves the angiogenic properties of endothelial progenitor cells. Am J Physiol Cell Physiol. 2012; 303, C954–C962.