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Perinatal overnutrition and the programming of food preferences: pathways and mechanisms

Published online by Cambridge University Press:  14 May 2012

Z. Y. Ong ,
J. R. Gugusheff  and
B. S. Muhlhausler
Z. Y. Ong
Affiliation:
Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia FOODplus Research Centre, School of Agriculture Food and Wine, The University of Adelaide, Adelaide, South Australia, Australia
J. R. Gugusheff
Affiliation:
FOODplus Research Centre, School of Agriculture Food and Wine, The University of Adelaide, Adelaide, South Australia, Australia
B. S. Muhlhausler*
Affiliation:
Sansom Institute for Health Research, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia FOODplus Research Centre, School of Agriculture Food and Wine, The University of Adelaide, Adelaide, South Australia, Australia
*
*Address for correspondence: Dr B. S. Muhlhausler, FOODplus Research Centre, School of Agriculture Food and Wine, The University of Adelaide, Adelaide 5064, South Australia, Australia. Email beverly.muhlhausler@adelaide.edu.au
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Abstract

One of the major contributing factors to the continuous rise in obesity rates is the increase in caloric intake, which is driven to a large extent by the ease of access and availability of palatable high-fat, high-sugar ‘junk foods’. It is also clear that some individuals are more likely to overindulge in these foods than others; however, the factors that determine an individual's susceptibility towards the overconsumption of palatable foods are not well understood. There is growing evidence that an increased preference for these foods may have its origins early in life. Recent work from our group and others has reported that in utero and early life exposure to these palatable foods in rodents increased the offspring's preference towards foods high in fat and sugar. One of the potential mechanisms underlying the programming of food preferences is the altered development of the mesolimbic reward system, a system that plays an important role in driving palatable food intake in adults. The aim of this review is to explore the current knowledge of the programming of food preferences, a relatively new and emerging area in the DOHAD field, with a particular focus on maternal overnutrition, the development of the mesolimbic reward system and the biological mechanisms which may account for the early origins of an increased preference for palatable foods.

Keywords

dopamineopioidprogrammingreward
Type
Review
Information
Journal of Developmental Origins of Health and Disease , Volume 3 , Issue 5 , October 2012 , pp. 299 - 308
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2012

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