1.Barker, DJP, Winter, PD, Osmond, C, Margetts, B, Simmonds, SJ. Weight in infancy and death from ischaemic heart disease. Lancet. 1989; 2, 577–580.
2.Barker, DJ, Eriksson, JG, Forsen, T, Osmond, C. Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol. 2002; 31, 1235–1239.
3.Yajnik, CS, Deshmukh, US. Maternal nutrition, intrauterine programming and consequential risks in the offspring. Rev Endocr Metab Disord. 2008; 9, 203–211.
4.Ehrenberg, HM, Dierker, L, Milluzzi, C, Mercer, BM. Prevalence of maternal obesity in an urban center. Am J Obstet Gynecol. 2002; 187, 1189–1193.
5.Catalano, PM, Ehrenberg, HM. The short- and long-term implications of maternal obesity on the mother and her offspring. BJOG. 2006; 113, 1126–1133.
6.Guo, F, Jen, KLC. High-fat feeding during pregnancy and lactation affects offspring metabolism in rats. Physiol Behav. 1995; 57, 681–686.
7.Khan, IY, Taylor, PD, Dekou, V, et al. Gender-linked hypertension in offspring of lard-fed pregnant rats. Hypertension. 2003; 41, 168–175.
8.Khan, I, Dekou, V, Hanson, M, Poston, L, Taylor, P. Predictive adaptive responses to maternal high-fat diet prevent endothelial dysfunction but not hypertension in adult rat offspring. Circulation. 2004; 110, 1097–1102.
9.Samuelsson, A-M, Matthews, PA, Argenton, M, et al. Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming. Hypertension. 2008; 51, 383–392.
10.Howie, GJ, Sloboda, DM, Kama, T, Vickers, MH. Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet. J Physiol. 2009; 587, 905–915.
11.Bjorntorp, P. Do stress reactions cause abdominal obesity and comorbidities? Obes Rev. 2001; 2, 73–86.
12.Marin, P, Darin, N, Amemiva, T, et al. Cortisol secretion in relation to body fat distribution in obese premenopausal women. Metabolism. 1992; 41, 882–886.
13.Rosmond, R, Bjorntorp, P. The interactions between hypothalamic-pituitary-adrenal axis activity, testosterone, insulin-like growth factor I and abdominal obesity with metabolism and blood pressure in men. Int J Obes Relat Metab Disord. 1998; 22, 1184–1196.
14.Rosmond, R, Dallman, MF, Bjorntorp, P. Stress-related cortisol secretion in men: relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities. J Clin Endocrinol Metab. 1998; 83, 61853–61859.
15.Rutters, F, Nieuwenhuizen, AG, Lemmens, SG, Born, JM, Westerterp-Plantenga, MS. Hypothalamus-Pituitary-Adrenal (HPA) axis functioning in relation to body fat distribution. Clin Endocrinol. 2010; 72, 738–743.
16.Lesage, J, Blondeau, B, Grino, M, Breant, B, Dupouy, JP. Maternal undernutrition during late gestation induces fetal overexposure to glucocorticoids and intrauterine growth retardation, and disturbs the hypothalamo-pituitary adrenal axis in the newborn rat. Endocrinology. 2001; 142, 1692–1702.
17.Bloomfield, FH, Oliver, MH, Giannoulias, CD, et al. Brief undernutrition in late-gestation sheep programs the hypothalamic-pituitary-adrenal axis in adult offspring. Endocrinology. 2003; 144, 2933–2940.
18.Entringer, S, Kumsta, R, Hellhammer, DH, Wadhwa, PD, Wust, S. Prenatal exposure to maternal psychosocial stress and HPA axis regulation in young adults. Horm Behav. 2009; 55, 292–298.
19.King, BM, Smith, RL. Hypothalamic obesity after hypophysectomy or adrenalectomy: dependence on corticosterone. Am J Physiol. 1985; 249, R522–R526.
20.Freedman, MR, Horwitz, BA, Stern, JS. Effect of adrenalectomy and glucocorticoid replacement on the development of obesity. Am J Physiol. 1986; 250, R595–R607.
21.Cherradi, N, Capponi, AM, Gaillard, RC, Pralong, FP. Decreased expression of steroidogenic acute regulatory protein: a novel mechanism participating in the leptin-induced inhibition of glucocorticoid biosynthesis. Endocrinology. 2001; 142, 3302–3308.
22.Hsu, HT, Chang, YC, Chiu, YN, et al. Leptin interferes with adrenocorticotropin/3′,5′-cyclic adenosine monophosphate (cAMP) signaling, possibly through a Janus kinase 2-phosphatidylinositol 3-kinase/Akt-phosphodiesterase 3-cAMP pathway, to down-regulate cholesterol side-chain cleavage cytochrome P450 enzyme in human adrenocortical NCI-H295 cell line. J Clin Endocrinol Metab. 2006; 91, 2761–2769.
23.Shibuya, I, Utsunomiya, K, Toyohira, Y, et al. Regulation of catecholamine synthesis by leptin. Ann N Y Acad Sci. 2002; 971, 522–527.
24.Trevenzoli, IH, Valle, MM, Machado, FB, et al. Neonatal hyperleptinaemia programmes adrenal medullary function in adult rats: effects on cardiovascular parameters. J Physiol. 2007; 580, 629–637.
25.Glasgow, A, Haidan, A, Hilbers, U, et al. Expression of Ob receptor in normal human adrenals: differential regulation of adrenocortical and adrenomedullary function by leptin. J Clin Endocrinol Metab. 1998; 83, 4459–4466.
26.Pralong, FP, Roduit, R, Waeber, G, et al. Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal gland. Endocrinology. 1998; 139, 4264–4268.
27.Chelikani, PK, Glimm, DR, Kennelly, JJ. Tissue distribution of leptin and leptin receptor mRNA in the bovine. J Dairy Sci. 2003; 86, 2369–2372.
28.Cao, GY, Considine, RV, Lynn, RB. Leptin receptors in the adrenal medulla of the rat. Am J Physiol. 1997; 273, E448–E452.
29.Takekoshi, K, Motooka, M, Isobe, K, et al. Leptin directly stimulates catecholamine secretion and synthesis in cultured porcine adrenal medullary cells. Biochem Biophys Res Commun. 1999; 261, 426–431.
30.Malendowicz, LK, Rucinski, M, Belloni, AS, Ziolkowska, A, Nussdorfer, GG. Leptin and the regulation of the hypothalamic-pituitary-adrenal axis. Int Rev Cytol. 2007; 263, 63–102.
31.Kelner, KL, Pollard, HB. Glucocorticoid receptors and regulation of phenylethanolamine-N-methyltransferase activity in cultured chromaffin cells. J Neurosci. 1985; 5, 2161–2168.
32.Vander Tuig, JG, Kerner, J, Romsos, DR. Hypothalamic obesity, brown adipose tissue, and sympathoadrenal activity in rats. Am J Physiol Endocrinol Metab. 1985; 248, E607–E617.
33.Wurtman, RJ, Axelrod, J. Control of enzymatic synthesis of adrenaline in the adrenal medulla by adrenal cortical steroids. J Biol Chem. 1966; 241, 2301–2305.
34.Thoenen, H, Mueller, RA, Axelrod, J. Neuronally dependent induction of phenylethanolamlne-N-methyl transferase by 6-hydroxydopamine. Biochem Pharmacol. 1970; 19, 669–673.
35.Zhu, W, Huang, X, Li, M, Neubauer, H. Elevated plasma homocysteine in obese schoolchildren with early atherosclerosis. Eur J Pediatr. 2005; 165, 326–331.
36.Karatela, RA, Sainani, GS. Plasma homocysteine in obese, overweight and normal weight hypertensives and normotensives. Indian Heart J. 2009; 61, 156–159.
37.Austin, RC, Lentz, SR, Werstuck, GH. Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease. Cell Death Differ. 2004; 11, S56–S64.
38.Franken, DG, Boers, GHJ, Blom, HJ, Trijibels, FJM, Kloppenborg, PW. Treatment of mild hyperhomocysteinemia in vascular disease patients. Arterioscler Thromb. 1994; 14, 465–470.
39.Selhub, J, Jacques, PF, Wilson, PWF, Rush, D, Rosenberg, IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA. 1993; 270, 2693–2698.
40.Mudd, SH, Havlik, R, Levy, HL, McKusick, VA, Feinleib, M. Cardiovascular risk in heterozygotes for homocystinuria. Am J Hum Gen. 1982; 34, 1018–1021.
41.Frosst, P, Blom, HJ, Milos, R, et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995; 10, 111–113.
42.Austin, RC, Lentz, SR, Werstuck, GH. Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease. Cell Death Differ. 2004; 11, S56–S64.
43.Martin, JL, Begun, J, McLeish, MJ, Caine, JM, Grunewald, GL. Getting the adrenaline going: crystal structure of the adrenaline-synthesizing enzyme PNMT. Structure. 2001; 9, 977–985.
44.Rozen, S, Skaletsky, HJ. Primer3 on the WWW for general users and for biologist programmers. In Bioinformatics Methods and Protocols: Methods in Molecular Biology, 1st edn (eds. Krawetz S, Misener S), 2000; pp. 365–386. Humana Press, Totowa, New Jersey.
45.Viegas, MS, Martins, TC, Seco, F, do Carmo, A. An improved and cost-effective methodology for the reduction of autofluorescence in direct immunofluorescence studies on formalin-fixed paraffin-embedded tissues. Euro J Histochem. 2007; 51, 59–66.
46.Gardner, DS, Van Bon, BW, Dandrea, J, et al. Effect of periconceptional undernutrition and gender on hypothalamic-pituitary-adrenal axis function in young adult sheep. J Endocrinol. 2006; 190, 203–212.
47.Connor, KL, Bloomfield, FH, Oliver, MH, Harding, JE, Challis, JRG. Effect of periconceptional undernutrition in sheep on late gestation expression of mRNA and protein from genes involved in fetal adrenal steroidogenesis and placental prostaglandin production. Reprod Sci. 2009; 16, 573–583.
48.Salzmann, C, Otis, M, Long, H, et al. Inhibition of steroidogenic response to adrenocrticotropin by leptin: implications for the adrenal response to maternal separation in neonatal rats. Endocrinology. 2004; 145, 1810–1822.
49.Utsunomiya, K, Yanagihara, N, Tachikawa, E, et al. Stimulation of catecholamine synthesis in cultured bovine adrenal medullary cells by leptin. J Neurochem. 2001; 76, 926–934.
50.Haycock, JW, Ahn, NG, Cobb, MH, Krebs, EG. ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ. Proc Natl Acad Sci USA. 1992; 89, 2365–2369.
51.Shibuya, I, Utsunomiya, K, Toyohira, Y, et al. Regulation of catecholamine synthesis by leptin. Ann N Y Acad Sci. 2002; 971, 522–527.
52.Boushey, CJ, Beresford, SA, Omenn, GS, Motulsky, AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA. 1995; 274, 1049–1057.
53.Siow, YL, Dakshinamurti, K. Effect of pyridoxine deficiency on aromatic L-amino acid decarboxylase in adult rat brain. Exp Brain Res. 1984; 59, 575–581.
54.Rees, WD. Manipulating the sulfur amino acid content of the early diet and its implications for long-term health. Proc Nutr Soc. 2002; 61, 71–77.
55.Langley-Evans, SC, Lilley, C, McMullen, S. Maternal protein restriction and fetal growth: lack of evidence of a role for homocysteine in fetal programming. Br J Nutr. 2006; 96, 578–586.
56.Engeham, SF, Haase, A, Langley-Evans, SC. Supplementation of a maternal low-protein diet in rat pregnancy with folic acid ameliorates programming effects upon feeding behaviour in the absence of disturbances to the methionine-homocysteine cycle. Br J Nutr. 2009; 27, 1–12.
57.Malendowicz, LK, Neri, G, Markowska, A, et al. Effects of leptin and leptin fragments on steroid secretion of freshly dispersed rat adrenocortical cells. J Steroid Biochem Mol Bio. 2003; 87, 265–268.
58.Rucinski, M, Tortorella, C, Ziolkowska, A, Nowak, M, Nussdorfer, GG, Malendowicz, LK. Steroidogenic acute regulatory protein gene expression, steroid-hormone secretion and proliferative activity of adrenocortical cells in the presence of proteasome inhibitors: In vivo studies on the regenerating rat adrenal cortex. Int J Mol Med. 2008; 21, 593–597.