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Insulin-like growth factor-1 and lipoprotein profile in cord blood of preterm small for gestational age infants

Published online by Cambridge University Press:  28 August 2013

N. Nagano ,
T. Okada ,
R. Fukamachi ,
K. Yoshikawa ,
S. Munakata ,
Y. Usukura ,
S. Hosono ,
S. Takahashi ,
H. Mugishima  and
M. Matsuura
...Show all authors
N. Nagano
Affiliation:
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan
T. Okada*
Affiliation:
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan
R. Fukamachi
Affiliation:
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan
K. Yoshikawa
Affiliation:
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan
S. Munakata
Affiliation:
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan
Y. Usukura
Affiliation:
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan
S. Hosono
Affiliation:
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan
S. Takahashi
Affiliation:
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan
H. Mugishima
Affiliation:
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan
M. Matsuura
Affiliation:
Department of Obstetrics and Gynecology, Nihon University School of Medicine, Tokyo, Japan
T. Yamamoto
Affiliation:
Department of Obstetrics and Gynecology, Nihon University School of Medicine, Tokyo, Japan
*
*Address for correspondence: T. Okada MD, Department of Pediatrics and Child Health, Nihon University School of Medicine30-1 Oyaguchi Kamicho, Itabashi-ku, Tokyo 173-8610, Japan. (Email okada.tomoo@nihon-u.ac.jp)
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Abstract

Low birth weight was associated with cardiometabolic diseases in adult age. Insulin-like growth factor-1 (IGF-1) has a crucial role in fetal growth and also associates with cardiometabolic risks in adults. Therefore, we elucidated the association between IGF-1 level and serum lipids in cord blood of preterm infants. The subjects were 41 consecutive, healthy preterm neonates (27 male, 14 female) born at <37-week gestational age, including 10 small for gestational age (SGA) infants (<10th percentile). IGF-1 levels and serum lipids were measured in cord blood, and high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC) and very low-density lipoprotein triglyceride (VLDLTG) levels were determined by HPLC method. SGA infants had lower IGF-1 (13.1 ± 5.3 ng/ml), total cholesterol (TC) (55.0 ± 14.8), LDLC (21.6 ± 8.3) and HDLC (26.3 ± 11.3) levels, and higher VLDLTG levels (19.0 ± 12.7 mg/dl) than in appropriate for gestational age (AGA) infants (53.6 ± 25.6, 83.4 ± 18.9, 36.6 ± 11.1, 38.5 ± 11.6, 8.1 ± 7.0, respectively). In simple regression analyses, log IGF-1 correlated positively with birth weight (r = 0.721, P < 0.001), TC (r = 0.636, P < 0.001), LDLC (r = 0.453, P = 0.006), and HDLC levels (r = 0.648, P < 0.001), and negatively with log TG (r = −0.484, P = 0.002) and log VLDL-TG (r = −0.393, P = 0.018). Multiple regression analyses demonstrated that IGF-1 was an independent predictor of TC, HDLC and TG levels after the gestational age and birth weight were taken into account. In preterm SGA infants, cord blood lipids profile altered with the concomitant decrease in IGF-1 level.

Keywords

high-density lipoproteininsulin-like growth factor-1neonate
Type
Original Article
Information
Journal of Developmental Origins of Health and Disease , Volume 4 , Issue 6 , December 2013 , pp. 507 - 512
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2013 

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