Barker, DJ. The origins of the developmental origins theory. J Intern Med. 2007; 261, 412–417.
Gluckman, PD, Hanson, MA, Cooper, C, Thornburg, KL. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 2008; 359, 61–73.
Hoy, WE, Hughson, MD, Bertram, JF, Douglas-Denton, R, Amann, K. Nephron number, hypertension, renal disease, and renal failure. J Am Soc Nephrol. 2005; 16, 2557–2564.
Dorey, ES, Pantaleon, M, Weir, KA, Moritz, KM. Adverse prenatal environment and kidney development: implications for programming of adult disease. Reproduction. 2014; 147, R189–R198.
5. Hoy, WE, Hughson, MD, Zimanyi, M, et al. Distribution of volumes of individual glomeruli in kidneys at autopsy: association with age, nephron number, birth weight and body mass index. Clin Nephrol. 2010; 74(Suppl 1), S105–S112.
Bertram, JF, Cullen-McEwen, LA, Egan, GF, et al. Why and how we determine nephron number. Pediatr Nephrol. 2014; 29, 575–580.
Dickinson, H, Walker, DW, Cullen-McEwen, L, Wintour, EM, Moritz, K. The spiny mouse (Acomys cahirinus) completes nephrogenesis before birth. Am J Physiol Renal Physiol. 2005; 289, F273–F279.
Singh, RR, Denton, KM, Bertram, JF, Dowling, J, Moritz, KM. Urine-concentrating defects exacerbate with age in male offspring with a low-nephron endowment. Am J Physiol Renal Physiol. 2011; 301, F1168–F1176.
Singh, RR, Jefferies, AJ, Lankadeva, YR, et al. Increased cardiovascular and renal risk is associated with low nephron endowment in aged females: an ovine model of fetal unilateral nephrectomy. PLoS One. 2012; 7, e42400.
Wlodek, ME, Mibus, A, Tan, A, et al. Normal lactational environment restores nephron endowment and prevents hypertension after placental restriction in the rat. J Am Soc Nephrol. 2007; 18, 1688–1696.
Grantham, JJ. Clinical practice. Autosomal dominant polycystic kidney disease. N Engl J Med. 2008; 359, 1477–1485.
Chapman, AB, Devuyst, O, Eckardt, KU, et al. Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a kidney disease: improving global outcomes (KDIGO) controversies conference. Kidney Int. 2015; 88, 17–27.
Otto, EA, Trapp, ML, Schultheiss, UT, et al. NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis. J Am Soc Nephrol. 2008; 19, 587–592.
Perrichot, RA, Mercier, B, de Parscau, L, et al. Inheritance of a stable mutation in a family with early-onset disease. Nephron. 2001; 87, 340–345.
Devuyst, O, Persu, A, Vo-Cong, MT. Autosomal dominant polycystic kidney disease: modifier genes and endothelial dysfunction. Nephrol Dial Transplant. 2003; 18, 2211–2215.
Barker, DJ, Martyn, CN. The maternal and fetal origins of cardiovascular disease. J Epidemiol Community Health. 1992; 46, 8–11.
Dipple, KM, McCabe, ER. Modifier genes convert “simple” Mendelian disorders to complex traits. Mol Genet Metab. 2000; 71, 43–50.
Orskov, B, Christensen, KB, Feldt-Rasmussen, B, Strandgaard, S. Low birth weight is associated with earlier onset of end-stage renal disease in Danish patients with autosomal dominant polycystic kidney disease. Kidney Int. 2012; 81, 919–924.
McCooke, JK, Appels, R, Barrero, RA, et al. A novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8. BMC Genomics. 2012; 13, 393.
Liu, S, Lu, W, Obara, T, et al. A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish. Development. 2002; 129, 5839–5846.
Phillips, JK, Hopwood, D, Loxley, RA, et al. Temporal relationship between renal cyst development, hypertension and cardiac hypertrophy in a new rat model of autosomal recessive polycystic kidney disease. Kidney Blood Press Res. 2007; 30, 129–144.
Consortium, S, Saar, K, Beck, A, et al. SNP and haplotype mapping for genetic analysis in the rat. Nat Genet. 2008; 40, 560–566.
Cullen-McEwen, LA, Armitage, JA, Nyengaard, JR, Moritz, KM, Bertram, JF. A design-based method for estimating glomerular number in the developing kidney. Am J Physiol Renal Physiol. 2011; 300, F1448–F1453.
Schindelin, J, Arganda-Carreras, I, Frise, E, et al. Fiji: an open-source platform for biological-image analysis. Nat Methods. 2012; 9, 676–682.
Edmunds, JW, Jayapalan, S, DiMarco, NM, Saboorian, MH, Aukema, HM. Creatine supplementation increases renal disease progression in Han:SPRD-cy rats. Am J Kidney Dis. 2001; 37, 73–78.
Hales, CN, Ozanne, SE. For debate: fetal and early postnatal growth restriction lead to diabetes, the metabolic syndrome and renal failure. Diabetologia. 2003; 46, 1013–1019.
Eriksson, JG, Forsen, T, Tuomilehto, J, et al. Catch-up growth in childhood and death from coronary heart disease: longitudinal study. BMJ. 1999; 318, 427–431.
McCarty, R. Cross-fostering: elucidating the effects of gene environment interactions on phenotypic development. Neurosci Biobehav Rev. 2017; 73, 219–254.
Moritz, KM, Wintour, EM, Black, MJ, Bertram, JF, Caruana, G. Factors influencing mammalian kidney development: implications for health in adult life. Adv Anat Embryol Cell Biol. 2008; 196, 1–78.
Hostetter, TH, Olson, JL, Rennke, HG, Venkatachalam, MA, Brenner, BM. Hyperfiltration in remnant nephrons: a potentially adverse response to renal ablation. Am J Physiol. 1981; 241, F85–F93.
32. Simons, JL, Provoost, AP, Anderson, S, et al. Pathogenesis of glomerular injury in the fawn-hooded rat: early glomerular capillary hypertension predicts glomerular sclerosis. J Am Soc Nephrol. 1993; 3, 1775–1782.
Luyckx, VA, Bertram, JF, Brenner, BM, et al. Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease. Lancet. 2013; 382, 273–283.
Fowden, AL, Giussani, DA, Forhead, AJ. Intrauterine programming of physiological systems: causes and consequences. Physiology (Bethesda). 2006; 21, 29–37.
Graignic-Philippe, R, Dayan, J, Chokron, S, Jacquet, AY, Tordjman, S. Effects of prenatal stress on fetal and child development: a critical literature review. Neurosci Biobehav Rev. 2014; 43, 137–162.
Vikse, BE, Irgens, LM, Leivestad, T, Hallan, S, Iversen, BM. Low birth weight increases risk for end-stage renal disease. J Am Soc Nephrol. 2008; 19, 151–157.
Schrier, RW. Renal volume, renin-angiotensin-aldosterone system, hypertension, and left ventricular hypertrophy in patients with autosomal dominant polycystic kidney disease. J Am Soc Nephrol. 2009; 20, 1888–1893.
Van Vliet, BN, Chafe Ll Fau-Antic, V, Antic, V, et al. Direct and indirect methods used to study arterial blood pressure. J Pharmacol Toxicol Methods. 2000; 44, 361–373.
39. Crispi, F, Hernandez-Andrade, E, Pelsers, MM, et al. Cardiac dysfunction and cell damage across clinical stages of severity in growth-restricted fetuses. Am J Obstet Gynecol. 2008; 199, 254.e251–254.e258.
Tomek, J, Bub, G. Hypertension-induced remodelling: on the interactions of cardiac risk factors. J Physiol. 2017; 595, 4027–4036.
Grantham, JJ, Chapman, AB, Torres, VE. Volume progression in autosomal dominant polycystic kidney disease: the major factor determining clinical outcomes. Clin J Am Soc Nephrol. 2006; 1, 148–157.
42. Halvorson, CR, Bremmer, MS, Jacobs, SC. Polycystic kidney disease: inheritance, pathophysiology, prognosis, and treatment. Int J Nephrol Renovasc Dis. 2010; 3, 69–83.
Gretz, N, Ceccherini, I, Kranzlin, B, et al. Gender-dependent disease severity in autosomal polycystic kidney disease of rats. Kidney Int. 1995; 48, 496–500.
Silbiger, SR, Neugarten, J. The role of gender in the progression of renal disease. Adv Ren Replace Ther. 2003; 10, 3–14.
Veiras, LC, Girardi, ACC, Curry, J, et al. Sexual dimorphic pattern of renal transporters and electrolyte homeostasis.
J Am Soc Nephrol
. 2017; 28, 3504–3517.
Ding, A, Kalaignanasundaram, P, Ricardo, SD, et al. Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease. Clin Exp Pharmacol Physiol. 2012; 39, 917–929.
Ow, CP, Abdelkader, A, Hilliard, LM, Phillips, JK, Evans, RG. Determinants of renal tissue hypoxia in a rat model of polycystic kidney disease. Am J Physiol Regul Integr Comp Physiol. 2014; 307, R1207–R1215.
Canzian, F. Phylogenetics of the laboratory rat Rattus norvegicus. Genome Res. 1997; 7, 262–267.
Mrug, M, Zhou, J, Yang, C, et al. Genetic and informatic analyses implicate Kif12 as a candidate gene within the Mpkd2 locus that modulates renal cystic disease severity in the Cys1 cpk mouse. PLoS One. 2015; 10, e0135678.
50. Harris, PC, Torres, VE. Polycystic kidney disease. Annu Rev Med. 2009; 60, 321–337.
Singh, V. Polycystic kidney disease: a paradigm in major kidney disorders. Biochem Physiol. 2015; 4, 2.