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Impact of porcine maternal aerobic exercise training during pregnancy on endothelial cell function of offspring at birth

Published online by Cambridge University Press:  24 November 2011

S. C. Newcomer ,
P. Taheripour ,
M. Bahls ,
R. D. Sheldon ,
K. B. Foust ,
C. A. Bidwell  and
R. Cabot
S. C. Newcomer*
Affiliation:
Department of Health and Kinesiology, Purdue University, West Lafayette, IN, USA
P. Taheripour
Affiliation:
Department of Health and Kinesiology, Purdue University, West Lafayette, IN, USA
M. Bahls
Affiliation:
Department of Health and Kinesiology, Purdue University, West Lafayette, IN, USA
R. D. Sheldon
Affiliation:
Department of Health and Kinesiology, Purdue University, West Lafayette, IN, USA
K. B. Foust
Affiliation:
Department of Animal Sciences, Purdue University, West Lafayette, IN, USA
C. A. Bidwell
Affiliation:
Department of Animal Sciences, Purdue University, West Lafayette, IN, USA
R. Cabot
Affiliation:
Department of Animal Sciences, Purdue University, West Lafayette, IN, USA
*
*Address for correspondence: Dr Sean C. Newcomer, Ph.D., Department of Health and Kinesiology, Purdue University, Lambert Fieldhouse, 800 W. Stadium Avenue, West Lafayette, IN 47907, USA. (Email snewcome@purdue.edu)
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Abstract

The purpose of this investigation was to test the hypothesis that maternal exercise training during pregnancy enhances endothelial function in offspring at birth. Six-month-old gilts (n = 8) were artificially inseminated and randomized into exercise-trained (n = 4) and sedentary groups (n = 4). Exercise training consisted of 15 weeks of treadmill exercise. The thoracic aorta of offspring were harvested within 48 h after birth and vascular responsiveness to cumulative doses of endothelium-dependent (bradykinin: 10−11–10−6 M) and independent (sodium nitroprusside: 10−10–10−4 M) vasodilators were assessed using in vitro wire myography. Female offspring from the exercised-trained gilts had a significantly greater endothelium-dependent relaxation response in the thoracic aorta when compared with the male offspring and female offspring from the sedentary gilts. The results of this investigation demonstrate for the first time that maternal exercise during pregnancy produces an enhanced endothelium-dependent vasorelaxation response in the thoracic aortas of female offspring at birth.

Keywords

endothelium-dependent relaxationexercisefetal programming
Type
Brief Report
Information
Journal of Developmental Origins of Health and Disease , Volume 3 , Issue 1 , February 2012 , pp. 04 - 09
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2011

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