Hostname: page-component-78c5997874-j824f Total loading time: 0 Render date: 2024-11-17T19:34:58.676Z Has data issue: false hasContentIssue false
  • English
  • Français

Impact of porcine maternal aerobic exercise training during pregnancy on endothelial cell function of offspring at birth

Published online by Cambridge University Press:  24 November 2011

S. C. Newcomer ,
P. Taheripour ,
M. Bahls ,
R. D. Sheldon ,
K. B. Foust ,
C. A. Bidwell  and
R. Cabot
S. C. Newcomer*
Affiliation:
Department of Health and Kinesiology, Purdue University, West Lafayette, IN, USA
P. Taheripour
Affiliation:
Department of Health and Kinesiology, Purdue University, West Lafayette, IN, USA
M. Bahls
Affiliation:
Department of Health and Kinesiology, Purdue University, West Lafayette, IN, USA
R. D. Sheldon
Affiliation:
Department of Health and Kinesiology, Purdue University, West Lafayette, IN, USA
K. B. Foust
Affiliation:
Department of Animal Sciences, Purdue University, West Lafayette, IN, USA
C. A. Bidwell
Affiliation:
Department of Animal Sciences, Purdue University, West Lafayette, IN, USA
R. Cabot
Affiliation:
Department of Animal Sciences, Purdue University, West Lafayette, IN, USA
*
*Address for correspondence: Dr Sean C. Newcomer, Ph.D., Department of Health and Kinesiology, Purdue University, Lambert Fieldhouse, 800 W. Stadium Avenue, West Lafayette, IN 47907, USA. (Email snewcome@purdue.edu)
Get access Rights & Permissions [Opens in a new window]

Abstract

The purpose of this investigation was to test the hypothesis that maternal exercise training during pregnancy enhances endothelial function in offspring at birth. Six-month-old gilts (n = 8) were artificially inseminated and randomized into exercise-trained (n = 4) and sedentary groups (n = 4). Exercise training consisted of 15 weeks of treadmill exercise. The thoracic aorta of offspring were harvested within 48 h after birth and vascular responsiveness to cumulative doses of endothelium-dependent (bradykinin: 10−11–10−6 M) and independent (sodium nitroprusside: 10−10–10−4 M) vasodilators were assessed using in vitro wire myography. Female offspring from the exercised-trained gilts had a significantly greater endothelium-dependent relaxation response in the thoracic aorta when compared with the male offspring and female offspring from the sedentary gilts. The results of this investigation demonstrate for the first time that maternal exercise during pregnancy produces an enhanced endothelium-dependent vasorelaxation response in the thoracic aortas of female offspring at birth.

Keywords

endothelium-dependent relaxationexercisefetal programming
Type
Brief Report
Information
Journal of Developmental Origins of Health and Disease , Volume 3 , Issue 1 , February 2012 , pp. 04 - 09
Copyright
Copyright © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2011

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Gluckman, PD, Hanson, MA, Cooper, C, Thornburg, KL. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med. 2008; 359, 61–73.Google Scholar
2. Burns, SP, Desai, M, Cohen, RD, et al. Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation. J Clin Invest. 1997; 100, 1768–1774.Google Scholar
3. Burdge, GC, Slater-Jefferies, J, Torrens, C, et al. Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations. Br J Nutr. 2007; 97, 435–439.Google Scholar
4. Torrens, C, Hanson, MA, Gluckman, PD, Vickers, MH. Maternal undernutrition leads to endothelial dysfunction in adult male rat offspring independent of postnatal diet. Br J Nutr. 2009; 101, 27–33.CrossRefGoogle ScholarPubMed
5. Torrens, C, Snelling, TH, Chau, R, et al. Effects of pre- and periconceptional undernutrition on arterial function in adult female sheep are vascular bed dependent. Exp Physiol. 2009; 94, 1024–1033.Google Scholar
6. Samuelsson, AM, Matthews, PA, Argenton, M, et al. Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming. Hypertension. 2008; 51, 383–392.CrossRefGoogle ScholarPubMed
7. Hopkins, SA, Cutfield, WS. Exercise in pregnancy: weighing up the long-term impact on the next generation. Exerc Sport Sci Rev. 2011; 39, 120–127.CrossRefGoogle ScholarPubMed
8. Borodulin, KM, Evenson, KR, Wen, F, Herring, AH, Benson, AM. Physical activity patterns during pregnancy. Med Sci Sports Exerc. 2008; 4, 1901–1908.Google Scholar
9. Gale, CR, Jiang, B, Robinson, SM, et al. Maternal diet during pregnancy and carotid intima-media thickness in children. Arterioscler Thromb Vasc Biol. 2006; 26, 1877–1882.Google Scholar
10. Turk, JR, Laughlin, MH. Physical activity and atherosclerosis: which animal model? Can J Appl Physiol. 2004; 29, 657–683.Google Scholar
11. Newcomer, SC, Taylor, JC, Bowles, DK, Laughlin, MH. Endothelium-dependent and -independent relaxation in the forelimb and hindlimb vasculatures of swine. Comp Biochem Physiol A Mol Integr Physiol. 2007; 148, 292–300.Google Scholar
12. Blair, SN, Morris, JN. Healthy hearts – and the universal benefits of being physically active: physical activity and health. Ann Epidemiol. 2009; 19, 253–256.Google Scholar
13. Newcomer, SC, Thijssen, DH, Green, DJ. Effects of exercise on endothelium and endothelium/smooth muscle crosstalk: role of exercise-induced hemodynamics. J Appl Physiol. 2011; 111, 311–320.CrossRefGoogle Scholar
14. Streuling, I, Beyerlein, A, Rosenfeld, E, et al. Physical activity and gestational weight gain: a meta-analysis of intervention trials. BJOG. 2011; 118, 278–284.CrossRefGoogle ScholarPubMed
15. May, LE, Glaros, A, Yeh, HW, IIIClapp, JF, Gustafson, KM. Aerobic exercise during pregnancy influences fetal cardiac autonomic control of heart rate and heart rate variability. Early Hum Dev. 2010; 86, 213–217.Google Scholar
16. Ross, R. Atherosclerosis – an inflammatory disease. N Engl J Med. 1999; 340, 115–126.Google Scholar
17. Barker, DJ. In utero programming of chronic disease. Clin Sci (Lond). 1998; 95, 115–128.Google Scholar
18. IIIClapp, JF. The effects of maternal exercise on fetal oxygenation and feto-placental growth. Eur J Obstet Gynecol Reprod Biol. 2003; 110(Suppl 1), S80–S85.Google Scholar
19. Yan, MS, Matouk, CC, Marsden, PA. Epigenetics of the vascular endothelium. J Appl Physiol. 2010; 109, 916–926.Google Scholar
20. Laughlin, MH, Newcomer, SC, Bender, SB. Importance of hemodynamic forces as signals for exercise-induced changes in endothelial cell phenotype. J Appl Physiol. 2008; 104, 588–600.CrossRefGoogle ScholarPubMed
21. Boegehold, MA. Endothelium-dependent control of vascular tone during early postnatal and juvenile growth. Microcirculation. 2010; 17, 394–406.Google ScholarPubMed
22. Moritz, KM, Cuffe, JS, Wilson, LB, et al. Review: sex specific programming: a critical role for the renal renin–angiotensin system. Placenta. 2010; 31(Suppl), S40–S46.Google Scholar
23. Arnal, JF, Fontaine, C, Billon-Gales, A, et al. Estrogen receptors and endothelium. Arterioscler Thromb Vasc Biol. 2010; 30, 1506–1512.CrossRefGoogle ScholarPubMed