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Genome organization: connecting the developmental origins of disease and genetic variation

Part of: Liggins Institute, New Zealand and the Japanese DOHaD Society

Published online by Cambridge University Press:  29 August 2017

E. Jacobson ,
M. H. Vickers ,
J. K. Perry  and
J. M. O’Sullivan Open the ORCID record for J. M. O’Sullivan [Opens in a new window]
E. Jacobson
Affiliation:
Liggins Institute, University of Auckland, Grafton, Auckland, New Zealand
M. H. Vickers
Affiliation:
Liggins Institute, University of Auckland, Grafton, Auckland, New Zealand
J. K. Perry
Affiliation:
Liggins Institute, University of Auckland, Grafton, Auckland, New Zealand
J. M. O’Sullivan*
Affiliation:
Liggins Institute, University of Auckland, Grafton, Auckland, New Zealand
*
*Address for correspondence: J. M. O’Sullivan, Liggins Institute, University of Auckland, Auckland, 1142, New Zealand. (Email justin.osullivan@auckland.ac.nz)
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Abstract

An adverse early life environment can increase the risk of metabolic and other disorders later in life. Genetic variation can modify an individual’s susceptibility to these environmental challenges. These gene by environment interactions are important, but difficult, to dissect. The nucleus is the primary organelle where environmental responses impact directly on the genetic variants within the genome, resulting in changes to the biology of the genome and ultimately the phenotype. Understanding genome biology requires the integration of the linear DNA sequence, epigenetic modifications and nuclear proteins that are present within the nucleus. The interactions between these layers of information may be captured in the emergent spatial genome organization. As such genome organization represents a key research area for decoding the role of genetic variation in the Developmental Origins of Health and Disease.

Keywords

epigeneticsfunctional annotationgenome organizationGWASSNPs
Type
Review
Information
Journal of Developmental Origins of Health and Disease , Volume 9 , Issue 3: Themed Issue: NZ-Japan , June 2018 , pp. 260 - 265
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Copyright
© Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2017 

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