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Feasibility of collecting tumor samples of breast cancer patients diagnosed up to 50 years ago in the Child Health and Development Studies

  • N. Y. Krigbaum (a1), R. A. Rubin (a1), P. M. Cirillo (a1), M. B. Terry (a2), L. A. Habel (a3), C. Morris (a4) and B. A. Cohn (a1)...

Abstract

Environmental exposures during pregnancy may increase breast cancer risk for mothers and female offspring. Tumor tissue assays may provide insight regarding the mechanisms. This study assessed the feasibility of obtaining tumor samples and pathology reports from mothers (F0) who were enrolled in the Child Health and Development Studies during pregnancy from 1959 to 1967 and their daughters (F1) who developed breast cancer over more than 50 years of follow-up. Breast cancer cases were identified through linkage to the California Cancer Registry and self-report. Written consent was obtained from 116 F0 and 95 F1 breast cancer survivors to access their pathology reports and tumor blocks. Of those contacted, 62% consented, 13% refused and 24% did not respond. We obtained tissue samples for 57% and pathology reports for 75%, and if diagnosis was made ⩽10 years we obtained tissue samples and pathology reports for 91% and 79%, respectively. Obtaining pathology reports and tumor tissues of two generations is feasible and will support investigation of the relationship between early-life exposures and molecular tumor markers. However, we found that more recent diagnosis increased the accessibility of tumor tissue. We recommend that cohorts request consent for obtaining future tumor tissues at study enrollment and implement real-time tissue collection to enhance success of collecting tumor samples and data.

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Corresponding author

*Address for correspondence: N. Krigbaum, 1683 Shattuck Ave, Suite B, Berkeley, CA 94709-1611, USA. (Email: nkrigbaum@chdstudies.org)

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Authors contributed equally to this work.

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References

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1. Russo, IH, Russo, J. Pregnancy-induced changes in breast cancer risk. J Mammary Gland Biol Neoplasia. 2011; 16, 221233.
2. Russo, J, Moral, R, Balogh, GA, Mailo, D, Russo, IH. The protective role of pregnancy in breast cancer. Breast Cancer Res. 2005; 7, 131142.
3. Cohn, BA, Wolff, MS, Cirillo, PM, Sholtz, RI. DDT and breast cancer in young women: new data on the significance of age at exposure. Environ Health Perspect. 2007; 115, 14061414.
4. Cohn, BA, La Merrill, M, Krigbaum, NY, et al. DDT exposure in utero and breast cancer. J Clin Endocrinol Metab. 2015; 100, 28652872.
5. van den Berg, BJ, Christianson, RE, Oechsli, FW. The California Child Health and Development Studies of the school of public health, University of California at Berkeley. Paediatr Perinat Epidemiol. 1988; 2, 265282.
6. Personal communication with Lisa Godefroy Johnsonto receive the Women’s Health Initiative consent rates, 2015.
7. Personal communication with Meir Stampfer to receive the Health Professionals Follow-up Study consent rates, 2015.
8. Personal communication with Meir Stampfer to receive the Nurses’ Health Study consent rates, 2015.
9. Personal communication with Cynthia A. Kleeberger to receive The Sister Study consent rates, 2015.
10. Krieger, N, Habel, LA, Waterman, PD, et al. Analyzing historical trends in breast cancer biomarker expression: a feasibility study (1947–2009). NPJ Breast Cancer. 2015; 1, 15016.
11. Policies and procedures for access to and disclosure of confidential data from the California Cancer Registry, 2014. Retrieved 23 September 2015 from http://www.ccrcal.org/pdf/Data_Statistics/CCRPoliciesProcedures_v05.1.pdf.
12. College of American Pathologists. Laboratory of Pathology Online Policy Manual, CAP & CLIA Retention Requirements. Retrieved 16 June 2014 from http://home.ccr.cancer.gov/lop/intranet/policymanual/generalpolicy/CAPCLIA.asp.

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Feasibility of collecting tumor samples of breast cancer patients diagnosed up to 50 years ago in the Child Health and Development Studies

  • N. Y. Krigbaum (a1), R. A. Rubin (a1), P. M. Cirillo (a1), M. B. Terry (a2), L. A. Habel (a3), C. Morris (a4) and B. A. Cohn (a1)...

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