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The interaction of monensin and flaxseed hulls on ruminal and milk concentration of the mammalian lignan enterolactone in late-lactating dairy cows

  • Hélène V Petit (a1), Cristiano Côrtes (a1), Daniele da Silva (a2), Ricardo Kazama (a2), Nathalie Gagnon (a1), Chaouki Benchaar (a1), Geraldo T dos Santos (a2) and Lúcia M Zeoula (a2)...

Abstract

Four ruminally fistulated multiparous Holstein cows were assigned to a 4×4 Latin square design with a 2×2 factorial arrangement of treatments to study the effects of dietary supplementation of monensin and flaxseed hulls on ruminal and milk concentration of the mammalian lignan enterolactone (EL) and ruminal and faecal activity of β-glucuronidase. The hypothesis was that monensin supplementation has no effect on the incorporation of EL into milk when cows are fed flaxseed hulls. Treatments were: 1) control, neither flaxseed hulls nor monensin (CO); 2) diet containing (dry matter basis) 20% flaxseed hulls (FH); 3) diet with monensin (16 mg/kg of dry matter; MO); 4) diet containing 20% (dry matter basis) flaxseed hulls and 16 mg/kg monensin (HM). Intake of dry matter was higher for CO and MO than for FH and HM and monensin had no effect. Milk production decreased in cows fed flaxseed hulls while monensin had no effect. Production of 4% fat-corrected milk and concentrations of milk fat, lactose, urea N, and total solids were similar among treatments. Although there was a decrease in ruminal activity of β-glucuronidase when feeding flaxseed hulls, the metabolism of plant into mammalian lignans may be increased as shown by enhanced concentration of EL in the rumen and milk. Supplementation with flaxseed hulls then may contribute to favourably change milk composition for better human health by enhancing mammalian lignan EL concentration.

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Corresponding author

*For correspondence; e-mail: helene.petit@agr.gc.ca

References

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Adlercreutz, H & Mazur, W 1997 Phyto-oestrogens and western diseases. Annals of Medicine 29 95–120
Association of Official Analytical Chemists 1990 Official methods of analysis 15th edAOAC Washington, DC, USA
Bannwart, C, Adlercreutz, H, Wähälä, K, Kotiaho, T, Hesso, A, Brunow, G & Hase, T 1988 Identification of the phyto-oestrogen 3',7-dihydroxyisoflavan, an isomer of equol, in human urine and cow's milk. Biomedical and Environmental Mass Spectrometry 17 16
Beaud, D, Tailliez, P & Anba-Mondoloni, J 2005 Genetic characterization of the beta-glucuronidase enzyme from a human intestinal bacterium, Ruminococcus gnavus. Microbiology 151 23232330
Bell, JA, Griinari, JM & Kennelly, JJ 2006 Effect of safflower oil, flaxseed oil, monensin, and vitamin E on concentration of conjugated linoleic acid in bovine milk fat. Journal of Dairy Science 89 733748
Benson, JA, Reynolds, CK, Humphries, DJ, Rutter, SM & Beever, DE 2001 Effects of abomasal infusion of long-chain fatty acids on intake, feeding behavior and milk production in dairy cows. Journal of Dairy Science 84 11821191
Benzie, IFF & Strain, JJ 1999 Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. In Methods in Enzymology, pp. 1527 (Ed. Packer, L). Orlando, FL, USA: Academic Press, Vol. 299.
Borriello, SP, Setchell, KDR, Axelson, M & Lawson, AM 1985 Production and metabolism of lignans by the human faecal flora. Journal of Applied Bacteriology 58 3743
Broderick, GA 2004 Effect of low level monensin supplementation on the production of dairy cows fed alfalfa silage. Journal of Dairy Science 87 359–68
CCAC (Canadian Council on Animal Care) 1993 Guide to the Care and Use of Experimental Animals Vol. 1 (Eds Olfert, ED, Cross, BM and McWilliam, AA). CCAC, Ottawa, ON, Canada.
Côrtes, C, Gagnon, N, Benchaar, C, da Silva, D, Santos, GTD & Petit, HV 2008 In vitro metabolism of flax lignans by ruminal and fecal microbiota of dairy cows. Journal of Applied Microbiology 105 15851594
da Silva, DC, Santos, GTD, Branco, AF, Damasceno, JC, Kazama, R, Matsushita, M, Horst, JA, dos Santos, WBR & Petit, HV 2007 Production performance and milk composition of dairy cows fed whole or ground flaxseed with or without monensin. Journal of Dairy Science 90 29282936
Dhiman, TR, Satter, LD, Pariza, MW, Galli, MP, Albridht, K & Tolosa, MX 2000 Conjugated linoleic acid (CLA) content of milk from cows offered diets rich in linoleic and linolenic acid. Journal of Dairy Science 83 10161027
Dickinson, JM, Smith, GR, Rander, RD & Pemberton, IJ 1988 In vitro metabolism of formononetin and biochanin in bovine rumen fluid. Journal of Animal Science 66 19691973
Duffield, TF, LeBlanc, S, Bagg, R, Leslie, K, Ten Hag, J & Dick, P 2003 Effect of a monensin controlled release capsule on metabolic parameters in transition dairy cows. Journal of Dairy Science 86 11711176
Duffield, TF, Rabiee, AR & Lean, IJ 2008 A meta-analysis of the impact of monensin in lactating dairy cattle. Part 2. Production effects. Journal of Dairy Science 91 13471360
Frank, AA & Custer, LJ 1996 Diadzein and genistein concentration sin human milk after soy consumption. Clinical Chemistry 42 955964
Gagnon, N, Côrtes, C, da Silva, D, Kazama, R, dos Santos, G, Zeoula, L, Benchaar, C & Petit, HV 2009 Ruminal metabolism of flaxseed (Linum usitatissimum) lignans to the mammalian lignan enterolactone and its concentration in ruminal fluid, plasma, urine, and milk of dairy cows. British Journal of Nutrition doi:10.1017/S0007114509344104
Heinonen, S, Nurmi, T, Kiukkonen, K, Poutanen, K, Wähälä, K, Deyama, T, Nishibe, S & Adlercreutz, H 2001 In vitro metabolism of plant lignans: new precursors of mammalian lignans enterolactone and enterediol. Journal of Agriculture and Food Chemistry 49 31783186
Henderson, C 1973 The effects of fatty acids on pure cultures of rumen bacteria. Journal of Agricultural Science Cambridge 81 107112
Ipharraguerre, IR & Clark, JH 2003 Usefulness of ionophores for lactating dairy cows: A review. Animal Feed Science and Technology 106 3957
Jenab, M & Thompson, LU 1996 The influence of flaxseed and lignans on colon carcinogenesis and β-glucuronidase activity. Carcinogenesis 17 13431348
Kitts, DD, Yuan, YV, Wijewickreme, AN & Thompson, LU 1999 Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone. Molecular and Cellular Biochemistry 202 91–100
Knudsen, KEB, Serena, LU, Kjær, AKB, Tetens, I, Heinonen, S, Nurmi, T & Adlercreutz, H 2003 Rye bread in the diet of pigs enhances the formation of enterolactone and increases its levels in plasma, urine and feces. Journal of Nutrition 5 13681375
Maia, MRG, Chaudhary, LC, Figueres, L & Wallace, RJ 2007 Metabolism of polyunsaturated fatty acids and their toxicity to the microflora of the rumen. Antonie Van Leeuwenhoek 91 303314
Muir, AD & Westcott, ND 2000 Quantification of the lignan secoisolariciresinol diglucoside in baked goods containing flax seed or flax meal. Journal of Agricultural Food Chemistry 48 40484052
Murkies, AL, Wilcox, G & Davis, SR 1998 Phytoestrogens. Journal of Clinical Endocrinology and Metabolism 83 297303
National Research Council 2001 Nutrient Requirements of Dairy Cattle. 7th rev. ed.Nat. Acad. Press, Washington, DC, USA
Osborne, JK, Mutsvangwa, T, Alzahal, O, Duffield, TF, Bagg, R, Dick, P, Vessie, G & McBride, BW 2004 Effects of monensin on ruminal forage degradability and total tract diet digestibility in lactating dairy cows during grain-induced subacute ruminal acidosis. Journal of Dairy Science 87 18401847
Petit, HV, Dewhurst, RJ, Scollan, ND, Proulx, JG, Khalid, M, Haresign, W, Twagiramungu, H & Mann, GE 2002 Milk production and composition, ovarian function, and prostaglandin secretion of dairy cows fed omega-3 fats. Journal of Dairy Science 85 889899
Petit, HV & Gagnon, N 2009 Milk concentrations of the mammalian lignans enterolactone and enterodiol, milk production, and whole tract digestibility of dairy cows fed diets containing different concentrations of flaxseed meal. Animal Feed Science and Technology 152 103111
Phipps, RH, Wilkinson, JI, Jonker, LJ, Tarrant, M, Jones, AK & Hodge, A 2000 Effect of monensin on milk production of Holstein-Friesian dairy cows. Journal of Dairy Science 83 27892794
Raffaelli, B, Hoikkala, A, Leppälä, E & Wähälä, K 2002 Enterolignans. Journal of Chromatography B 777 2943
Ramanzin, M, Bailoni, L, Schiavon, S & Bittante, G 1997 Effect of monensin on milk production and efficiency of dairy cows fed two diets differing in forage to concentrate ratios. Journal of Dairy Science 80 11361142
Rowan, AM, Haggarty, NW & Ram, S 2005 Milk bioactives: discovery and proof of concept. Australian Journal of Dairy Technolology 60 114118
SAS. Statistical Analysis System, Release 8.02. 2000. Cary, NC., SAS Inst. Inc.
Sauer, FD, Fellner, V, Kinsman, R, Kramer, JKG, Jackson, HA, Lee, AJ & Chen, S 1998 Methane output and lactation response in Holstein cattle with monensin or unsaturated fat added to the diet. Journal of Animal Science 76 906914
Setchell, KDR, Lawson, AM, Mitchell, FL, Adlercreutz, H, Kirk, DN & Axelson, M 1980 Lignans in man and in animal species. Nature 287 740742
Smet, K, Raes, K, De Block, J, Herman, L, Dewettinck, K & Coudijzer, K 2008 A change in antioxidative capacity as a measure of onset to oxidation in pasteurized milk. International Dairy Journal 18 520530
Steinshamn, H, Purup, S, Thuen, E & Hansen-Møller, J 2008 Effects of clover-grass silages and concentrate supplementation on the content of phytoestrogens in dairy cow milk. J Dairy Sci 91 27152725
Tyrrell, HF & Reid, JT 1965 Prediction of the energy value of cow's milk. Journal of Dairy Science 48 12151223
Vanharanta, M, Voutilainen, S, Lakka, TA, Van der Lee, M, Adlercreutz, H & Salonen, JT 1999 Risk of acute coronary events according to serum concentrations of enterolactone: a prospective population-based case-control study. Lancet 354 21122115
Van Soest, PJ, Robertson, JB & Lewis, BA 1991 Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. Journal of Dairy Science 74 35833597

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The interaction of monensin and flaxseed hulls on ruminal and milk concentration of the mammalian lignan enterolactone in late-lactating dairy cows

  • Hélène V Petit (a1), Cristiano Côrtes (a1), Daniele da Silva (a2), Ricardo Kazama (a2), Nathalie Gagnon (a1), Chaouki Benchaar (a1), Geraldo T dos Santos (a2) and Lúcia M Zeoula (a2)...

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