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Effect of thermal treatment of whey contaminated with antibiotics on the growth of Kluyveromyces marxianus

  • Dafna Eluk (a1), Roberto Ceruti (a1), Orlando Nagel (a1) and Rafael Althaus (a1)

The objective of the studies reported in this research communication was to investigate the use of whey contaminated with antibiotics such as cephalosporins, quinolones and tetracyclines as a nutrient medium for the growth of Kluyveromyces marxianus with particular attention to the effect of thermal treatment used to overcome the inhibitory effects of antibiotic concentrations close to the Maximum Residue Limits. The heat treatments at 120 °C for 40 min, 120 °C for 83 min, and 120 °C for 91 min caused total inactivation of cephalosporins, tetracyclines and quinolone residues in whey respectively.

Corresponding author
Author for correspondence: Rafael Althaus, Email:
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Althaus, R, Nagel, O and Molina, P (2014) Efecto de antibióticos en suero de leche sobre la fermentación de K. marxianus [Effect of antibiotics in whey on the fermentation of K. marxianus]. Argentina. Concordia, Argentina. Libro. Resumen. Congreso. Food Innova – International Conference in Food Innovation –978-950698340-6.
European Community (2009) Council regulation No. 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin. Official Journal of the European Union 15, 172.
Roca, M, Castillo, M, Martí, P, Althaus, RL and Molina, MP (2010) Effect of heating on the stability of quinolones in milk. Journal of Agricultural Food Chemistry 58, 54275431.
Roca, M, Villegas, L, Kortabitarte, ML, Althaus, RL and Molina, MP (2011) Effect of heat treatments on stability of β-lactams in milk. Journal of Dairy Science 94, 11551164.
Siljanoski, A, Ciglarič, R, Pezdir, T, Lainšček, PR, Dolenc, J, Starič, J and Šinigoj-Gačnik, K (2018) Detection of tetracycline and other antimicrobial residues in milk from cows with clinical mastitis treated by combination therapy. Journal of Dairy Research 85, 321326.
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Zorraquino, MA, Althaus, RL, Nagel, OG, Roca, M and Molina, P (2010) Efecto de los Tratamientos Térmicos sobre la Actividad Antimicrobiana de Tetraciclinas en Leche [Effect of thermal treatments on the antimicrobial activity of tetracyclines in milk]. Revista de la Facultad de Ciencias Veterinarias de la Universidad Nacional del Litoral 9, 4756.
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Journal of Dairy Research
  • ISSN: 0022-0299
  • EISSN: 1469-7629
  • URL: /core/journals/journal-of-dairy-research
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