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Concentration of penicillin G in mammary tissue and secretion of end-term dairy heifers following systemic prepartum administration of penethamate hydriodide

Published online by Cambridge University Press:  29 September 2009

Pieter Passchyn ,
Sofie Piepers ,
Ellen Schmitt-Van de Leemput ,
Christian Guidarini  and
Sarne De Vliegher
Pieter Passchyn
Affiliation:
Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, Belgium Veterinary practice De Toren, Torhout, Belgium
Sofie Piepers
Affiliation:
Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, Belgium
Ellen Schmitt-Van de Leemput
Affiliation:
Veterinary practice, Villaines la Juhel, France
Christian Guidarini
Affiliation:
Boehringer Ingelheim Santé Animale, Reims, France
Sarne De Vliegher*
Affiliation:
Department of Reproduction, Obstetrics and Herd Health, Faculty of Veterinary Medicine, Ghent University, Belgium
*
*For correspondence; e-mail: Sarne.Devliegher@UGent.be
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Abstract

The aim of this study was to assess the concentration of penicillin G in mammary tissue and secretion of dry heifers following systemic administration of penethamate hydriodide. Six dairy heifers in late gestation received a single intramuscular injection of 10 g penethamate hydriodide and were sacrificed 24, 48 or 144 h after treatment. Penicillin G concentrations were measured in mammary tissue and secretion samples using HPLC. Penicillin G was detected in the udder of two animals euthanized at 24 h (mammary tissue and secretion) and at 48 h post treatment (mammary secretion only) after administration at concentrations still close to or above MIC90 values reported for the pathogens associated with heifer mastitis. Antibiotic concentration shortly after administration will have been substantially higher indicating a potential for systemic treatment with penethamate hydriodide to control prepartum intramammary infections in heifers without the disadvantages of local therapy such as teat contamination or risk of trauma for the administrator.

Keywords

Dairy heiferpenethamate hydriodideprepartum treatmentsystemic
Type
Research Article
Information
Journal of Dairy Research , Volume 77 , Issue 1 , February 2010 , pp. 33 - 36
Copyright
Copyright © Proprietors of Journal of Dairy Research 2009

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References

Bryan, MA & Friton, GM 2005 Stochastic economic modelling of the use of penethamate hydriodide (Mamyzin®). Proceedings of the 4th IDF International Mastitis Conference, Maastricht, The Netherlands pp.232–234CrossRefGoogle Scholar
De Vliegher, S, Barkema, HW, Stryhn, H, Opsomer, G & de Kruif, A 2004 Impact of early lactation somatic cell count in heifers on somatic cell counts over the first lactation. Journal of Dairy Science 87 3672–3682CrossRefGoogle ScholarPubMed
De Vliegher, S, Barkema, HW, Opsomer, G, de Kruif, A & Duchateau, L 2005a Association between somatic cell count in early lactation and culling of dairy heifers using Cox frailty models. Journal of Dairy Science 88 560–568Google Scholar
De Vliegher, S, Barkema, HW, Stryhn, H, Opsomer, G & de Kruif, A 2005b Impact of early lactation somatic cell count in heifers on milk yield over the first lactation. Journal of Dairy Science 88 938–947Google Scholar
Erskine, R, Cullor, J, Schallibaum, M, Yancey, B & Zecconi, A 2004 Bovine mastitis pathogens and trends in resistance to antimicrobial drugs. Proceedings of the 43rd NMC meeting, Charlotte NC, USA pp. 400–414Google Scholar
Friton, G, Van Hattum, JJC & Hörstermann, D 2003 Pharmacokinetics in plasma and milk of benzylpenicillin following repeated intramuscular administration of mamyzin (penethamate hydriodide) in lactating cows. Journal of Veterinary Pharmacology and Therapeutics 26 (Suppl. 1) 100–101Google Scholar
Fox, LK 2009 Prevalence, incidence and risk factors of heifer mastitis. Veterinary Microbiology 134 82–88Google Scholar
Gentilini, E, Denamiel, G, Betancor, A, Rebuelto, M, Rodriguez Fermepin, M & De Torres, RA 2002. Antimicrobial susceptibility of coagulase-negative staphylococci isolated from bovine mastitis in Argentina. Journal of Dairy Science 85 1913–1917Google Scholar
Huijps, K, De Vliegher, S, Lam, TJGM & Hogeveen, H 2009 Cost estimation of heifer mastitis in early lactation by stochastic modelling. Veterinary Microbiology 134 121–127Google Scholar
Kreiger, M, Friton, GM, Hofer, J, Fuchs, K & Winter, P 2007 Effects of periparturient systemic treatment with penethamate hydriodide on udder health and milk yield of dairy heifers. Journal of Dairy Research 74 392–398Google Scholar
Moroni, P, Casula, A, Spreafico, G, Ruffo, G & Bronzol, V 2002 New strategy in management and control of Staphylococcus aureus intramammary infections in Italian dairy herd. Proceedings of the 41st NMC meeting Orlando FL, USA pp.182–183Google Scholar
Nickerson, SC 2009 Control of heifer mastitis: antimicrobial treatment— An overview. Veterinary Microbiology 134 128–135Google Scholar
Oliver, SP & Mitchell, BA 1983 Intramammary infections in primigravid heifers near parturition. Journal of Dairy Science 66 1180–1183Google Scholar
Parker, KI, Compton, C, Anniss, FM, Weir, A, Heuer, C & McDougall, S 2007 Subclinical and clinical mastitis in heifers following the use of a teat sealant precalving. Journal of Dairy Science 90 207–218Google Scholar
Piepers, S, De Vliegher, S, Opsomer, G, de Kruif, A & Barkema, HW 2009 Impact of intramammary infections in dairy heifers on future udder health, milk production, and culling. Veterinary Microbiology 134 113–120Google Scholar
Roberson, JR, Fox, LK, Hancock, DD, Gay, CC & Besser, TE 1994 Coagulase-positive Staphylococcus intramammary infections in primiparous dairy cows. Journal of Dairy Science 77 958–969Google Scholar
Salat, O, Serieys, F, Poutrel, B, Durel, L & Goby, L 2008 Systemic treatment of subclinical mastitis in lactating cows with penethamate hydriodide. Journal of Dairy Science 91 632–640Google Scholar
Serieys, F, Raguet, Y, Goby, L, Schmidt, H & Friton, G 2005 Comparative efficacy of local and systemic antibiotic treatment in lactating cows with clinical mastitis. Journal of Dairy Science 88 93–99Google Scholar
Tarbin, J, Farrington, WHH & Shearer, G 1995 Determination of penicillins in animal tissues at trace residue concentrations. Part I. Determination of benzylpenicillin in milk by reversed-phase liquid chromatography with solid phase extraction and liquid chromatographic fractionation clean-up. Analytica Chimica Acta 318 95–101Google Scholar
Trinidad, P, Nickerson, SC & Alley, TK 1990 Prevalence of intramammary infection and teat canal colonization in unbred and primigravid dairy heifers. Journal of Dairy Science 73 107–114CrossRefGoogle ScholarPubMed
Ziv, G 1980 Practical pharmacokinetic aspects of mastitis therapy. 1. Parenteral treatment. Veterinary Clinics of North America Small Animal Practice 75 277–290Google Scholar