Ahrén, B, Gomis, R, Standl, E, Mills, D and Schweizer, A (2004) Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin treated patients with type 2 diabetes. Diabetes Care 27, 2874–2880.
Aihara, K, Ishii, H and Yoshida, M (2009) Casein-derived tripeptide, Val-Pro-Pro (VPP), modulates monocyte adhesion to vascular endothelium. Journal of Atherosclerosis and Thrombosis 16, 594–603.
Albenzio, M, Santillo, A, Caroprese, M, della Malva, A and Marino, R (2017) Bioactive peptides in animal food products. Foods (Basel, Switzerland) 6, 35–49.
Augustin, M and Udabage, P (2007) Influence of processing on functionality of milk and dairy proteins. Advances in Food and Nutrition Research 53, 1–38.
Awawdeh, M (2016) Rumen-protected methionine and lysine: effects on milk production and plasma amino acids of dairy cows with reference to metabolisable protein status. Journal of Dairy Research 83, 151–155.
Beltrán-Barrientos, LM, Hernández-Mendoza, A, Torres Llanez, MJ, González-Córdova, AF and Vallejo-Córdoba, B (2016) Fermented milk as antihypertensive functional food. Journal of Dairy Science 99, 4099–4110.
Bernabucci, U, Basiricò, L, Morera, P, Dipasquale, D, Vitali, A, Cappelli, FP and Calamari, LUIGI (2015) Effect of summer season on milk protein fractions in Holstein cows. Journal of Dairy Science 98, 1815–1827.
Bischoff, SC, Boirie, Y, Cederholm, T, Chourdakis, M, Cuerda, C, Delzenne, NM and Koletzko, B (2016) Towards a multidisciplinary approach to understand and manage obesity and related diseases. Clinical Nutrition 36, 917–938.
Bonanno, A (2012) Some like it healthy: demand for functional and conventional yogurts in the Italian market. Agribusiness 28, 67–85.
Cant, JP, DePeters, EJ and Baldwin, RL (1993) Mammary amino acid utilization in dairy cows fed fat and its relationship to milk protein depression. Journal of Dairy Science 76, 762–774.
Caroli, A, Chessa, S and Erhardt, G (2009) Invited review: milk protein polymorphisms in cattle: effect on animal breeding and human nutrition. Journal of Dairy Science 92, 5335–5352.
Castro, G, Maria, D, Bouhallab, S and Sgarbieri, V (2009) In vitro impact of a whey protein isolate (WPI) and collagen hydrolysates (CHs) on B16F10 melanoma cells proliferation. Journal of Dermatological Science 56, 51–57.
Cicero, A, Aubin, F, Azais-Braesco, V and Borghi, C (2013) Do the lactotripeptides isoleucine—proline—proline and valine—proline—proline reduce systolic blood pressure in European subjects? A meta-analysis of randomized controlled trials. American Journal of Hypertension 26, 442–449.
Claeys, WL, Verraes, C, Cardoen, S, De Block, J, Huyghebaert, A, Raes, K, Dewettinck, K and Herman, L (2014) Consumption of raw or heated milk from different species: an evaluation of the nutritional and potential health benefits. Food Control 42, 88–201.
Clare, D and Swaisgood, H (2000) Bioactive milk peptides: a prospectus. Journal of Dairy Science 83, 1187–1195.
Colombo, M, Todorov, SD, Eller, M and Nero, LA (2018) The potential use of probiotic and beneficial bacteria in the Brazilian dairy industry. Journal of Dairy Research 85, 487–496.
Cowley, FC, Barber, DG, Houlihan, AV and Poppi, DP (2015) Immediate and residual effects of heat stress and restricted intake on milk protein and casein composition and energy metabolism. Journal of Dairy Science 98, 2356–2368.
De Peters, E and Cant, JP (1992) Nutritional factors influencing the nitrogen composition of bovine milk: a review. Methionine and lysine on casein in milk when diets high in fat or concentrate are fed. Journal of Dairy Science 75, 2043–2070.
Dionysius, D and Milne, J (1997) Antibacterial peptides of bovine lactoferrin: purification and characterization. Journal of Dairy Science 80, 667–674.
Dux, M, Muranowicz, M, Siadkowska, E, Robakowska-Hyżorek, D, Flisikowski, K, Bagnicka, E and Zwierzchowski, L (2018) Association of SNP and STR polymorphisms of insulin-like growth factor 2 receptor (IGF2R) gene with milk traits in Holstein-Friesian cows. Journal of Dairy Research 85, 138–141.
Espejo-Carpio, F, Pérez-Gálvez, R, Guadix, A and Guadix, E (2018) Artificial neuronal networks (ANN) to model the hydrolysis of goat milk protein by subtilisin and trypsin. Journal of Dairy Research 85, 339–346.
Food and Agriculture Organization of the United Nations (FAO) (2013) .
Galán-Malo, P, Valares, JA, Langa, V, Razquin, P and Mata, L (2014) Determination of IgG levels in bulk ewe's milk. Small Ruminant Research 119, 156–160.
Gandini, G, Turri, F, Rizzi, R, Crotta, M, Minozzi, G and Pizzi, F (2017) Economic evaluation of genetic improvement in local breeds: the case of the Verzaschese goat. Italian Journal of Animal Science 16, 199–207.
Gauthier, SF, Pouliot, Y and Saint-Sauveur, D (2006) Immunomodulatory peptides obtained by the enzymatic hydrolysis of whey proteins. International Dairy Journal 16, 1315–1323.
Gerosa, S and Skoet, J (2012) .
Giacometti, J and Buretić-Tomljanović, A (2017) Peptidomics as a tool for characterizing bioactive milk peptides. Food Chemistry 230, 91–98.
Giambra, IJ, Brandt, G and Erhardt, G (2014) Milk protein variants are highly associated with milk performance traits in East Friesian Dairy and Lacaune sheep. Small Ruminant Research 121, 382–394.
Givens, I (2018) Milk and dairy foods: implications for cardiometabolic health. Cardiovascular Endocrinology and Metabolism 7, 56–57.
Grainger, C, Auldist, MJ, O'Brien, G, Macmillan, KL and Culley, C (2009) Effect of type of diet and energy intake on milk production of Holstein-Friesian cows with extended lactations. Journal of Dairy Science 92, 1479–1492.
Hao, LY, Wang, J, Sun, P and Bu, DP (2016) The effect of heat stress on the metabolism of dairy cows: updates and review. Austin Journal of Nutrition and Metabolism 3, 10363–11041.
Heck, J, Schennink, A, van Valenberg, H, Bovenhuis, H, Visker, M, van Arendonk, J and van Hooijdonk, A (2009) Effects of milk protein variants on the protein composition of bovine milk. Journal of Dairy Science 92, 1192–1202.
Hernández-Castellano, LE, Almeida, AM, Castro, N and Argüello, A (2014) The colostrum proteome, ruminant nutrition and immunity: a review. Current Protein and Peptide Science 15, 64–74.
Hernández-Castellano, LE, Ferreira, AM, Nanni, P, Grossmann, J, Argüello, A, Capote, J, Cai, G, Lippolis, J, Castro, N and de Almeida, AM (2016 a) The goat (Capra hircus) mammary gland secretory tissue proteome as influenced by weight loss: a study using label free proteomics. Journal of Proteomics 145, 60–69.
Hernández-Castellano, LE, Almeida, A, Renaut, J, Argüello, A and Castro, N (2016 b) A proteomics study of colostrum and milk from the two major small ruminant dairy breeds from the Canary Islands: a bovine milk comparison perspective. Journal of Dairy Research 83, 366–374.
Ho, CH, Chang, CJ, Liu, WB, Peh, HC, Chen, SE, Chen, HY, Ho, TH, Chen, MT and Nagahata, H (2010) In situ generation of milk protein-derived peptides in drying-off cows. Journal of Dairy Research 7, 487–497.
Hu, Z-L and Reecy, J (2007) Animal QTLdb: beyond a repository. A public platform for QTL comparisons and integration with diverse types of structural genomic information. Mammalian Genome 18, 1–4.
Jenkins, TC and McGuire, MA (2006) Major advances in nutrition: impact on milk composition. Journal of Dairy Science 89, 1302–1310.
Johansen, M, Lund, P and Weisbjerg, MR (2017) Feed intake and milk production in dairy cows fed different grass and legume species: a meta-analysis. Animal: An International Journal of Animal Bioscience 12, 66–75.
Khatkar, MS, Thomson, PC, Tammen, I and Raadsma, HW (2004) Quantitative trait loci mapping in dairy cattle: review and meta-analysis. Genetics, Selection, Evolution 36, 163–190.
Khatoon, JA and Josh, VK (1987) Effect of different heat treatments on protease-peptone and non protein nitrogen contents of goat milk. Indian Journal of Dairy Science 40, 243–245.
Korhonen, H (2009) Milk-derived bioactive peptides: from science to applications. Journal of Functional Foods 1, 177–187.
Korhonen, H and Pihlanto, A (2007) Technological options for the production of health-promoting proteins derived from milk and colostrum. Current Pharmaceutical Design 13, 829–843.
Lee, C, Giallongo, F, Hristov, AN, Lapierre, H, Cassidy, TW, Heyler, KS and Parys, C (2015) Effect of dietary protein level and rumen-protected amino acid supplementation on amino acid utilization for milk protein in lactating dairy cows. Journal of Dairy Science 98, 1885–1902.
Lee, M, Lee, H and Kim, J (2018) Dairy food consumption is associated with a lower risk of the metabolic syndrome and its components: a systematic review and meta-analysis. British Journal of Nutrition 120, 373–384.
Lérias, JR, Hernández-Castellano, LE, Morales-delaNuez, A, Araújo, SS, Castro, N, Argüello, A and Almeida, AM (2013) Body live weight and milk production parameters in the Majorera and Palmera goat breeds from the Canary Islands: influence of weight loss. Tropical Animal Health and Production 45, 1731–1736.
Mackle, TR, Bryant, AM, Petch, SF, Hooper, RJ and Auldist, MJ (1999) Variation in the composition of milk protein from pasture-fed dairy cows in late lactation and the effect of grain and silage supplementation. New Zealand Journal of Agricultural Research 42, 147–154.
Madureira, AR, Tavares, T, Gomes, AMP, Pintado, ME and Malcata, FX (2010) Invited review: physiological properties of bioactive peptides obtained from whey proteins. Journal of Dairy Science 93, 437–455.
Marcone, S, Belton, O and Fitzgerald, D (2017) Milk derived bioactive peptides and their health promoting effects: a potential role in atherosclerosis. British Journal of Clinical Pharmacology 83, 152–162.
Mather, IH (2000) A review and proposed nomenclature for major proteins of the milk-fat globule membrane. Journal of Dairy Science 83, 203–247.
McGregor, RA and Poppitt, SD (2013) Milk protein for improved metabolic health: a review of the evidence. Nutrition and Metabolism 10, 46–59.
Mendis, S (2017) Global progress in prevention of cardiovascular disease. Cardiovascular Diagnosis and Therapy 7, 32–38.
Min, B, Hart, S, Sahlu, T and Satter, L (2005) The effect of diets on milk production and composition and on lactation curves in pastured dairy goats. Journal of Dairy Science 88, 2604–2615.
Moreno-Indias, I, Morales-delaNuez, A, Hernández-Castellano, LE, Sánchez-Macías, D, Capote, J, Castro, N and Argüello, A (2012) Docosahexaenoic acid in the goat kid diet: effects on immune system and meat quality. Journal of Animal Science 90, 3729–3738.
Morton, G, Cummings, D, Baskin, D, Barsh, G and Schwartz, M (2006) Central nervous system control of food intake and body weight. Nature 443, 289–295.
Murgiano, L, Timperio, AM, Zolla, L, Bongiorni, S, Valentini, A and Pariset, L (2009) Comparison of milk fat globule membrane (MFGM) proteins of Chianina and Holstein cattle breed milk samples through proteomics methods. Nutrients 1, 302–315.
Muro, U, Álvarez, F, Rodriguez, R, Cuenca, A and Jurado, T (2011) Review: production and functionality of active peptides from milk. Food Science and Technology International 17, 293–317.
National Research Council (NRC) (2001) Nutrient Requirements of Dairy Cattle, 7th Edn. Washington, DC: National Academy Press.
Neelima, SR, Rajput, Y and Mann, B (2013) Chemical and functional properties of glycomacropeptide (GMP) and its role in the detection of cheese whey adulteration in milk: a review. Dairy Science and Technology 93, 21–43.
Olaniyan, B, Zhao, X and Mustafa, A (2013) Determination of caprine serum albumin in milk using bromocresol green dye. Open Journal of Animal Sciences 3, 261–267.
Ong, L and Shah, NP (2008) Release and identification of angiotensin-converting enzyme-inhibitory peptides as influenced by ripening temperatures and probiotic adjuncts in Cheddar cheeses. Journal of Food Science and Technology 41, 1555–1566.
Palma, M, Alves, SP, Hernández-Castellano, LE, Capote, J, Castro, N, Argüello, A, Matzapetakis, M, Bessa, RJB and de Almeida, AM (2017) Mammary gland and milk fatty acid composition of two dairy goat breeds under feed-restriction. Journal of Dairy Research 84, 264–271.
Pasin, G and Comerford, KB (2015) Dairy foods and dairy proteins in the management of type 2 diabetes: a systematic review of the clinical evidence. Advances in Nutrition 6, 245–259.
Patra, AK and Saxena, J (2011) Exploitation of dietary tannins to improve rumen metabolism and ruminant nutrition. Journal of the Science of Food and Agriculture 91, 24–37.
Pereira, PC (2014) Milk nutritional composition and its role in human health. Nutrition 30, 619–627.
Perez Espitia, PJ, Soares, NFF, Coimbra, JSR, Andrade, NJ, Cruz, RS and Medeiros, EAA (2012) Bioactive peptides: synthesis, properties, and applications in the packaging and preservation of food. Comprehensive Reviews in Food Science and Food Safety 11, 187–204.
Rabiee, AR, Breinhild, K, Scott, W, Golder, HM, Block, E and Lean, IJ (2012) Effect of fat additions to diets of dairy cattle on milk production and components: a meta-analysis and meta-regression. Journal of Dairy Science 95, 3225–3247.
Ricci-Cabello, I, Olalla Herrera, M and Artacho, R (2012) Possible role of milk-derived bioactive peptides in the treatment and prevention of metabolic syndrome. Nutrition Reviews 70, 241–255.
Roman, S, Sanchez-Siles, LM and Siegrist, M (2017) The importance of food naturalness for consumers: results of a systematic review. Trends in Food Science and Technology 67, 44–57.
Ryan, J, Ross, R, Bolton, D, Fitzgerald, G and Stanton, C (2011) Bioactive peptides from muscle sources: meat and fish. Nutrients 3, 765–791.
Sah, BNP, Vasiljevic, T, Mckechnie, S and Donkor, ON (2015) Identification of anticancer peptides from bovine milk proteins and their potential roles in management of cancer: a critical review. Comprehensive Reviews in Food Science and Food Safety 14, 123–138.
Sahingil, D, Hayaloglu, A, Kirmaci, H, Özer, B and Simsek, O (2014) Changes of proteolysis and Angiotensin-I converting enzyme-inhibitory activity in white-brined cheese as affected by adjunct culture and ripening temperature. Journal of Dairy Research 81, 394–402.
Sok, M, Ouellet, DR, Firkins, JL, Pellerin, D and Lapierre, H (2017) Amino acid composition of rumen bacteria and protozoa in cattle. Journal of Dairy Science 100, 5241–5249.
Tacoma, R, Fields, J, Ebenstein, DB, Lam, YW and Greenwood, SL (2016) Characterization of the bovine milk proteome in early-lactation Holstein and Jersey breeds of dairy cows. Journal of Proteomics 130, 200–210.
Tacoma, R, Fields, J, Ebenstein, DB, Lam, YW and Greenwood, SL (2017) Ratio of dietary rumen degradable protein to rumen undegradable protein affects nitrogen partitioning but does not affect the bovine milk proteome produced by mid-lactation Holstein dairy cows. Journal of Dairy Science 100, 7246–7261.
Tidona, F, Criscione, A, Guastella, AM, Zuccaro, A, Bordonaro, S and Marletta, D (2009) Bioactive peptides in dairy products. Italian Journal of Animal Science 8, 315–340.
Uchida, M, Oshiba, Y and Mogami, O (2011) Novel dipeptidyl peptidase-4-inhibiting peptide derived from β-lactoglobulin. Journal of Pharmacological Sciences 117, 63–66.
Uenishi, H, Kabuki, T, Seto, Y, Serizawa, Y and Nakajima, D (2012) Isolation and identification of casein-derived dipeptidyl-peptidase 4 (DPP-4)-inhibitory peptide LPQNIPPL from gouda-type cheese and its effect on plasma glucose in rats. International Dairy Journal 22, 24–30.
Vacca, G, Dettori, M, Piras, G, Manca, F, Paschino, P and Pazzola, M (2014) Goat casein genotypes are associated with milk production traits in the Sarda breed. Animal Genetics 45, 723–731.
Walker, G, Dunshea, B and Doyle, A (2004) Effects of nutrition and management on the production and composition of milk fat and protein: a review. Australian Journal of Agricultural Research 55, 1009–1028.
Wu, Z and Huber, JT (1994) Relationship between dietary fat supplementation and milk protein concentration in lactating cows: a review. Livestock Production Science 39, 141–155.
Xue, L, Wang, X, Hu, Z, Wu, Z, Wang, L, Wang, H and Yang, M (2018) Identification and characterization of an angiotensin-converting enzyme inhibitory peptide derived from bovine casein. Peptides 99, 161–168.
Zhao, R, Kaakati, R, Lee, AK, Liu, X, Li, F and Li, CY (2018) Novel roles of apoptotic caspases in tumor repopulation, epigenetic reprogramming, carcinogenesis, and beyond. Cancer and Metastasis Reviews 37, 227–236.