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Fluid resuscitation-associated increased mortality and inflammatory cytokine expression in murine polymicrobial sepsis

  • Young Im Lee (a1) (a2) (a3), Robert L. Smith (a1) (a2), Erin J. Caraher (a1), George Crowley (a1), Syed Hissam Haider (a1), Sophia Kwon (a1) and Anna Nolan (a1) (a2)...
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http://creativecommons.org/licenses/by-nc-sa/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is included and the original work is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use

Corresponding author

*Address for correspondence: A. Nolan, M.D., M.S., Associate Professor of Medicine and Environmental Medicine, Division of Pulmonary, Critical Care and Sleep, New York University School of Medicine, New Bellevue, 7 N Room 24. 462 1st Avenue, New York, NY 10016, USA. (Email: anna.nolan@med.nyu.edu)

References

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1. Rivers, E, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. New England Journal of Medicine 2001; 345: 13681377.
2. Wiedemann, HP, et al. Comparison of two fluid-management strategies in acute lung injury. New England Journal of Medicine 2006; 354: 25642575.
3. Maitland, K, et al. Mortality after fluid bolus in African children with severe infection. New England Journal of Medicine 2011; 364: 24832495.
4. Marik, PE. Early management of severe sepsis: concepts and controversies. Chest 2014; 145: 14071418.
5. Nolan, A, et al. Differential role for Cd80 and Cd86 in the regulation of the innate immune response in murine polymicrobial sepsis. PLoS One 2009; 4: e6600.
6. Maitland, K, et al. Exploring mechanisms of excess mortality with early fluid resuscitation: insights from the feast trial. BMC Medicine 2013; 11: 68.
7. Myburgh, J, Finfer, S. Causes of death after fluid bolus resuscitation: new insights from feast. BMC Medicine 2013; 11: 67.

Fluid resuscitation-associated increased mortality and inflammatory cytokine expression in murine polymicrobial sepsis

  • Young Im Lee (a1) (a2) (a3), Robert L. Smith (a1) (a2), Erin J. Caraher (a1), George Crowley (a1), Syed Hissam Haider (a1), Sophia Kwon (a1) and Anna Nolan (a1) (a2)...

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