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Genetics and Child Psychiatry: I Advances in Quantitative and Molecular Genetics

  • Michael Rutter (a1), Judy Silberg (a2), Thomas O'Connor (a1) and Emily Simonoff (a3)

Abstract

Advances in quantitative psychiatric genetics as a whole are reviewed with respect to conceptual and methodological issues in relation to statistical model fitting, new genetic designs, twin and adoptee studies, definition of the phenotype, pervasiveness of genetic influences, pervasiveness of environmental influences, shared and nonshared environmental effects, and nature–nurture interplay. Advances in molecular genetics are discussed in relation to the shifts in research strategies to investigate multifactorial disorders (affected relative linkage designs, association strategies, and quantitative trait loci studies); new techniques and identified genetic mechanisms (expansion of trinucleotide repeats, genomic imprinting, mitochondrial DNA, fluorescent in-situ hybridisation, behavioural phenotypes, and animal models); and the successful localisation of genes.

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Corresponding author

Requests for reprints to: Professor Sir Michael Rutter, Social, Genetic, and Developmental Research Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, U.K.

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