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Genetic Association between Atopy and Behavioral Symptoms in Middle Childhood

Published online by Cambridge University Press:  01 October 1998

Marianne Z. Wamboldt ,
Stephanie Schmitz  and
David Mrazek
Marianne Z. Wamboldt
Affiliation:
National Jewish Medical and Research Center, Denver, the University of Colorado Health Sciences Center, Denver, and the University of Colorado, Boulder, U.S.A.
Stephanie Schmitz
Affiliation:
University of Colorado Health Sciences Center, Denver, and the University of Colorado, Boulder, U.S.A.
David Mrazek
Affiliation:
Children's National Medical Center, Washington DC, U.S.A.
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Abstract

The relationship of atopic and behavioral symptoms in a community sample of 66 monozygotic and 141 dizygotic twin pairs, ages 4–11 years, was investigated via mother report questionnaires. Within-person correlation between atopic symptoms and Child Behavior Checklist internalizing symptoms (CBCL-INT) was .21 (p<.001) for the total sample. Cross-correlations between atopy and CBCL-INT were .26 for monozygotic and .04 for dizygotic twins. A common and specific factor model applied to the data revealed that the cross-correlation between atopy and CBCL-INT was mainly due to genetic influences (77% of the covariance). This study supports the hypothesis that there is a shared genetic risk for atopy and internalizing symptoms.

Keywords

Externalizing disorderinternalizing disorderasthmaschool childrentwinsgenetics
Type
Research Article
Information
The Journal of Child Psychology and Psychiatry and Allied Disciplines , Volume 39 , Issue 7 , October 1998 , pp. 1007 - 1016
Copyright
© 1998 Association for Child Psychology and Psychiatry

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