Skip to main content Accessibility help

Estimation of inbreeding from population samples

  • Cedric A. B. Smith and Robert Thomson


Some simple methods of estimating inbreeding from tests on a random sample of individuals are discussed. These are mostly iterative procedures, converging to the maximum likelihood estimate, with algorithms for finding standard errors. But there are problems of interpretation, both from the statistical and biological points of view.



Hide All
Castle, W. E. (1903) The laws of Galton and Mendel and some laws governing race improvement by selection. Proc. Amer. Acad. Arts. Sci. 39, 233242.
Ceppellini, R., Siniscalo, M. and Smith, C. A. B. (1955) The estimation of gene frequencies in a random mating population. Ann. Hum. Genet. 20, 97115.
Dempster, A. P., Laird, N. M. and Rubin, D. B. (1977) Maximum likelihood from incomplete data via the EM algorithm. J. R. Statist. Soc. B 39, 138.
Edwards, A. W. F. (1972) Likelihood. Cambridge University Press, Cambridge.
Hardy, G. H. (1908) Mendelian proportions in a mixed population. Science 28, 4950.
Mourant, A. E. (1954) Distribution of the Human Blood Groups. Blackwell, London.
Pedersen, J. G. (1978) A note on the likelihood equation in the ABO blood group system. Ann. Hum. Genet. 42, 231237.
Savage, L. J. (1954) The Foundations of Statistics. Wiley, New York.
Schull, W. J. and Ito, Y. U. (1969) Note on the estimation of the ABO gene frequencies and the coefficient of inbreeding. Am. J. Hum. Genet. 1, 168177.
Smith, C. A. B. (1957) Counting methods in genetical statistics. Ann. Hum. Genet. 21, 168177.
Smith, C. A. B. (1961) Consistency in Statistical Inference and Decision. J. R. Statist. Soc. B 23, 125.
Weinberg, W. (1908) Über den Nachweis der Vererbung beim Menschen. Jh. Ver. Vaterl. Naturb. Wurttemb. 64, 368382.


Estimation of inbreeding from population samples

  • Cedric A. B. Smith and Robert Thomson


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed