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Temporal expression of the matrix metalloproteinase MMP-2 correlates with fibronectin immunoreactivity during the development of the vascular system in the chick embryo chorioallantoic membrane

Published online by Cambridge University Press:  01 July 1999

DOMENICO RIBATTI ,
BEATRICE NICO ,
ANGELO VACCA ,
MONICA IURLARO  and
LUISA RONCALI
DOMENICO RIBATTI
Affiliation:
Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Bari, Italy
BEATRICE NICO
Affiliation:
Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Bari, Italy
ANGELO VACCA
Affiliation:
Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy
MONICA IURLARO
Affiliation:
Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy
LUISA RONCALI
Affiliation:
Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Bari, Italy
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Abstract

In this study we have examined in the chick embryo chorioallantoic membrane (ChAM) the expression of the matrix metalloproteinase 2 (MMP-2) and have correlated this parameter with the expansion of the ChAM vasculature and with the expression of 3 extracellular matrix components (fibronectin, laminin and type IV collagen), which differentially modulate angiogenesis. In the early phases of ChAM development, between d 6 and d 8 of incubation, when the increase of the ChAM vasculature is maximal, higher values of MMP-2 and, respectively, of fibronectin immunoreactive area, are detectable. These results indicate that MMP-2 activity and fibronectin expression are 2 strictly related components of angiogenesis occurring in vivo.

Keywords

Angiogenesismetalloproteinase 2
Type
Research Article
Information
The Journal of Anatomy , Volume 195 , Issue 1 , July 1999 , pp. 39 - 44
Copyright
© Anatomical Society of Great Britain and Ireland 1999

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